carpinusin

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 单宁
• 英文名称: carpinusin
• 英文别名: [(1R,2R,9R,10R,19R,20S,39S)-8,8,9,13,14,25,26,27,30,31,32-undecahydroxy-4,7,17,22,35-pentaoxo-3,18,21,36,38,40-hexaoxaoctacyclo[18.17.1.12,19.19,12.05,10.011,16.023,28.029,34]tetraconta-5,11,13,15,23,25,27,29,31,33-decaen-39-yl] 3,4,5-trihydroxybenzoate
• 化学式: C₄₁H₂₈O₂₇
• 分子量: 952.657
• InChiKey: KTMJANHHXHZLEU-AHSVKIOASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  68
• 可旋转键数：
  3
• 环数：
  9.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  450
• 氢给体数：
  14
• 氢受体数：
  27

反应信息

• 作为反应物：
  描述：

  carpinusin 在 吡啶 、 美司坦 、 ammonium formate 作用下， 以 水 、 乙腈 为溶剂， 反应 20.0h， 生成 (R)-1,2,6-Triacetoxy-7-acetyl-4,11-dioxo-4,8,9,11-tetrahydro-7H-5,12-dioxa-10-thia-7-aza-benzo[def]chrysene-8-carboxylic acid methyl ester
  参考文献：
  名称：

  Tanaka, Takashi; Fujisaki, Hiroshi; Nonaka, Gen-ichiro, Heterocycles, 1992, vol. 33, # 1, p. 375 - 383

  摘要：

  DOI：

文献信息

• Tannins and Related Compounds. CXVIII. Structures, Preparation, High-Performance Liquid Chromatography and Some Reactions of Dehydroellagitannin-Acetone Condensates.
  作者：Takashi TANAKA、Hiroshi FUJISAKI、Gen-ichiro NONAKA、Itsuo NISHIOKA

  DOI：10.1248/cpb.40.2937

  日期：——

  The dehydroellagitannins having a dehydrohexahydroxydiphenoyl ester group in the molecule were found to undergo highly regio- and stereospecific condensation with acetone in the presence of ammonium ion under almost neutral conditions. This reaction was successfully applied to high-performance liquid chromatographic analysis to detect the dehydroellagitannins in the plant extract. Furthermore, the reactions of the acetone condensates with L-cysteine methyl ester were examined, and appear to be applicable to structural studies of dehydroellagitannins.

  含有脱氢六羟基二苯酰酯基的脱氢椴树单宁在几乎中性的条件下，与氨离子存在时与丙酮发生高度区域选择性和立体选择性的缩合反应。该反应成功应用于高效液相色谱分析，以检测植物提取物中的脱氢椴树单宁。此外，还研究了丙酮缩合物与L-半胱氨酸甲酯的反应，似乎适用于脱氢椴树单宁的结构研究。
• Tannins and related compounds. XCV. Isolation and characterization of helioscopinins and helioscopins, four new hydrolyzable tannins from Euphorbia helioscopia L. (1).
  作者：Seung-Ho LEE、Takashi TANAKA、Gen-ichiro NONAKA、Itsuo NISHIOKA

  DOI：10.1248/cpb.38.1518

  日期：——

  A chemical examination of polyphenols in Euphorbia helioscopia L. (Euphorbiaceae) has led to the isolation of four new hydrozable tannins named helioscopinins A (10) and B (9), and helioscopins A (11) and B (12), together with eight known tannins (1-8). On the basis of chemical and spectroscopic evidence, the structures of compounds 9-12 were established as 1, 6-(S)-hexahydroxydiphenoyl-3-O-galloyl-β-D-glucose, 1, 6-(S)-hexahydroxydiphenoyl-2, 4-(S)-dehydrohexahydroxydiphenoyl-3-O-galloyl-β-D-glucose, 1, 6-(S)-hexahydroxydiphenoyl-2, 4-(R)-elaeocarpusionoyl-3-O-galloyl-β-D-glucose and 1, 3, 6-tri-O-galloyl-2, 4-(R)-elaeocarpusinoyl-β-D-glucose, respectively.

  对大戟科植物日照大戟（Euphorbia helioscopia L.）中的多酚进行了化学分析，分离出四种新的水解鞣酸，分别命名为helioscopinins A (10) 和 B (9)，以及helioscopins A (11) 和 B (12)，同时还发现了八种已知的鞣酸（1-8）。根据化学和光谱证据，化合物9-12的结构被确认分别为：1, 6-(S)-六羟基二苯酰基-3-O-鞣酸基-β-D-葡萄糖，1, 6-(S)-六羟基二苯酰基-2, 4-(S)-脱氢六羟基二苯酰基-3-O-鞣酸基-β-D-葡萄糖，1, 6-(S)-六羟基二苯酰基-2, 4-(R)-油青果酸-3-O-鞣酸基-β-D-葡萄糖和1, 3, 6-三-O-鞣酸基-2, 4-(R)-油青果酸-β-D-葡萄糖。
• Tanaka, Takashi; Fujisaki, Hiroshi; Nonaka, Gen-ichiro, Heterocycles, 1992, vol. 33, # 1, p. 375 - 383
  作者：Tanaka, Takashi、Fujisaki, Hiroshi、Nonaka, Gen-ichiro、Nishioka, Itsuo

  DOI：——

  日期：——