3-(6-羟基-2,7,8-三甲基色满-2-基)丙酸 | 178167-77-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 中文名称: 3-(6-羟基-2,7,8-三甲基色满-2-基)丙酸
• 中文别名: 2-吗啉-4-基乙基2-[(4-氯苯基)氨基]吡啶-3-羧酸酯盐酸
• 英文名称: racemic 2,7,8-trimethyl-2-(β-carboxyethyl) chroman
• 英文别名: 2,7,8-trimethyl-2-(β-carboxyethyl) chroman；3-(2,7,8-trimethyl-3,4-dihydro-2H-1-benzopyran-2-yl)propanoic acid；3-(2,7,8-trimethyl-3,4-dihydrochromen-2-yl)propanoic acid
• CAS: 178167-77-6
• 化学式: C₁₅H₂₀O₃
• 分子量: 248.322
• InChiKey: WTGHQIKMADLFAH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  5-乙烯基-5-甲基四氢呋喃-2-酮 、 二甲酚 在 三氟化硼乙醚 作用下， 以 1,4-二氧六环 为溶剂， 反应 1.0h， 以24%的产率得到3-(6-羟基-2,7,8-三甲基色满-2-基)丙酸
  参考文献：
  名称：

  Kantoci, Darko; Wechter, William J.; Murray Jr., E. David, Journal of Pharmacology and Experimental Therapeutics, 1997, vol. 282, # 2, p. 648 - 656

  摘要：

  DOI：

文献信息

• Use of .gamma.-tocopherol and its oxidative metabolite LLU-.alpha. in
  申请人：Loma Linda University Medical Center

  公开号：US06048891A1

  公开（公告）日：2000-04-11

  The present invention is generally related to the discovery of the therapeutic benefit of administering .gamma.-tocopherol and .gamma.-tocopherol derivatives. More specifically, the use of .gamma.-tocopherol and racemic LLU-.alpha., (S)-LLU-.alpha., or .gamma.-tocopherol derivatives as antioxidants and nitrogen oxide scavengers which treat and prevent high blood pressure, thromboembolic disease, cardiovascular disease, cancer, natriuretic disease, the formation of neuropathological lesions, and a reduced immune system response are disclosed.

  本发明一般涉及于发现给予γ-生育酚和γ-生育酚衍生物治疗的益处。更具体地，本发明揭示了使用γ-生育酚和外消旋的LLU-α、(S)-LLU-α或γ-生育酚衍生物作为抗氧化剂和氮氧化物清除剂，治疗和预防高血压、血栓栓塞病、心血管疾病、癌症、利钠性疾病、神经病理性病变的形成和免疫系统反应减弱。
• Use of gamma-tocopherol and its oxidative metabolite LLU-alpha in the treatment of disease
  申请人：——

  公开号：US20010031782A1

  公开（公告）日：2001-10-18

  The present invention is generally related to the discovery of the therapeutic benefit of administering &ggr;-tocopherol and &ggr;-tocopherol derivatives. More specifically, the use of &ggr;-tocopherol and racemic LLU-&agr;, (S)-LLU-&agr;, or &ggr;-tocopherol derivatives as antioxidants and nitrogen oxide scavengers which treat and prevent high blood pressure, thromboembolic disease, cardiovascular disease, cancer, natriuretic disease, the formation of neuropathological lesions, and a reduced immune system response are disclosed.

  本发明通常涉及发现给予&ggr;-生育酚和&ggr;-生育酚衍生物的治疗效益。更具体地，本发明揭示了使用&ggr;-生育酚和外消旋的LLU-&agr;，(S)-LLU-&agr;或&ggr;-生育酚衍生物作为抗氧化剂和氮氧化物清除剂，用于治疗和预防高血压、血栓栓塞性疾病、心血管疾病、癌症、利钠性疾病、神经病理性病变的形成以及免疫系统反应降低等。
• Use of gamma- tocopherol and its oxidative metabolite LLU-alpha in the treatment of disease
  申请人：Wechter J. William

  公开号：US20060223881A1

  公开（公告）日：2006-10-05

  The present invention is generally related to the discovery of the therapeutic benefit of administering γ-tocopherol and γ-tocopherol derivatives. More specifically, the use of γ-tocopherol and racemic LLU-α, (S)-LLU-α, or γ-tocopherol derivatives as antioxidants and nitrogen oxide scavengers which treat and prevent high blood pressure, thromboembolic disease, cardiovascular disease, cancer, natriuretic disease, the formation of neuropathological lesions, and a reduced immune system response are disclosed.

  本发明一般涉及发现给予γ-生育酚和γ-生育酚衍生物治疗的疗效。更具体地，揭示了使用γ-生育酚和外消旋LLU-α，(S)-LLU-α或γ-生育酚衍生物作为抗氧化剂和氮氧化物清除剂，用于治疗和预防高血压，血栓栓塞性疾病，心血管疾病，癌症，利钠性疾病，神经病理性病变的形成以及免疫系统反应减弱。
• Natriuretic compounds
  申请人：Loma Linda University Medical

  公开号：US06083982A1

  公开（公告）日：2000-07-04

  Compounds, methods and compositions are provided for inducing natriuresis in a mammal. Methods for isolating and synthesizing the natriuretic compounds are also provided. Therapeutic methods using the natriuretic compounds are also provided. The natriuretic compounds are capable of inducing sodium excretion in a mammal without inducing corresponding prolonged potassium excretion.

  本发明提供了一种在哺乳动物中诱导排钠作用的化合物、方法和组合物。同时，本发明还提供了分离和合成利尿化合物的方法。本发明还提供了使用利尿化合物的治疗方法。这些利尿化合物能够在不引起相应的持久性钾排泄的情况下诱导哺乳动物的钠排泄。
• Compositions and methods for the prevention and treatment of cerebral ischemia
  申请人：——

  公开号：US20020143049A1

  公开（公告）日：2002-10-03

  The present invention provides compositions and methods for the treatment of cerebral ischemia. In particular, the present invention provides gamma-, beta-, or delta-tocopherol enriched tocopherol compositions and gamma-, beta-, or delta-tocopherol metabolite enriched compositions and methods for their use in preventing or treating a cerebral ischemic condition. The present invention also provides pharmaceutical compositions comprising gamma-, beta-, or delta-tocopherol enriched tocopherol composition or a gamma-, beta-, or delta-tocopherol metabolite enriched composition in an amount effective to reduce neuronal damage related to a cerebral ischemic condition.

  本发明提供了治疗脑缺血的组合物和方法。特别是，本发明提供了γ-、β-或δ-生育酚富集生育酚组合物和γ-、β-或δ-生育酚代谢物富集组合物及其用于预防或治疗脑缺血病症的方法。本发明还提供了药物组合物，其中包含γ-、β-或δ-生育酚富集生育酚组合物或γ-、β-或δ-生育酚代谢物富集组合物，其用量可有效减少与脑缺血状况相关的神经元损伤。