Cyclobutyl 4-prop-2-ynylpiperidine-1-carboxylate | 1072908-15-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: Cyclobutyl 4-prop-2-ynylpiperidine-1-carboxylate
• CAS: 1072908-15-6
• 化学式: C₁₃H₁₉NO₂
• 分子量: 221.299
• InChiKey: KVILFPZROCTPSP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.77
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  Cyclobutyl 4-prop-2-ynylpiperidine-1-carboxylate 、 (2S,3S,4R,5R)-5-(6-amino-2-iodo-9H-purin-9-yl)-N-cyclopropyl-3,4-dihydroxytetrahydrofuran-2-carboxamide 在 四(三苯基膦)钯 copper(l) iodide 、 三乙胺 作用下， 以 2-氨基-3-氯-1,4-萘醌 、 N,N-二甲基甲酰胺 为溶剂， 以30%的产率得到4-{3-[6-amino-9-((2R,3R,4S,5S)-5-cyclopropylcarbamoyl-3,4-dihydroxytetrahydrofuran-2-yl)-9H-purin-2-yl]-2-propynyl}-piperidine-1-carboxylic acid cyclobutyl ester
  参考文献：
  名称：

  WO2008/130520

  摘要：

  公开号：
• 作为产物：
  描述：

  4-丙-2-炔基哌啶 、 cyclobutyl 2,5-dioxopyrrolidin-1-yl carbonate 在 三乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 24.0h， 以60%的产率得到Cyclobutyl 4-prop-2-ynylpiperidine-1-carboxylate
  参考文献：
  名称：

  WO2008/130520

  摘要：

  公开号：

文献信息

• SUBSTITUTED 4--PIPERIDINE-1-CARBOXYLIC ACID ESTERS AS A2AR AGONISTS
  申请人：Thompson Robert D.

  公开号：US20090162292A1

  公开（公告）日：2009-06-25

  The present invention provides substituted 4-3-[6-amino-9-(3,4-dihydroxy-tetrahydro-furan-2-yl)-9H-purin-2-yl]-prop-2-ynyl}-piperidine-1-carboxylic acid esters and pharmaceutical compositions containing the same that are selective agonists of A 2A adenosine receptors (ARs). These compounds and compositions are useful as pharmaceutical agents.

  本发明提供了替代的4-3-[6-氨基-9-(3,4-二羟基-四氢呋喃-2-基)-9H-嘌呤-2-基]-丙-2-炔基}-哌啶-1-羧酸酯及含有它们的药物组合物，这些化合物和组合物是A2A腺苷受体选择性激动剂。这些化合物和组合物可用作药物制剂。
• THERAPEUTIC AGENT FOR GLAUCOMA CONTAINING ADENOSINE DERIVATIVE AS ACTIVE INGREDIENT
  申请人：Shimazaki Atsushi

  公开号：US20100093770A1

  公开（公告）日：2010-04-15

  A method for treating glaucoma or ocular hypertension comprising administering to a patient a pharmacologically effective amount of a compound represented by the following (1) or a salt thereof: wherein X represents CH or N; R 1 represents a hydrogen atom, a hydroxy group, a halogen atom, an alkyl group, an alkoxy group, a cycloalkyl group, a cycloalkoxy group, a (cycloalkyl)methoxy group, or R 2 represents a hydrogen atom, an alkyl group, a cycloalkyl group, an alkylcarbonyl group or an alkyloxycarbonyl group; and R a and R b are the same or different and represent a hydrogen atom, a hydroxy group, a halogen atom, an alkyl group, an alkoxy group, a cycloalkyl group or a cycloalkoxy group.
• METHOD FOR TREATING GLAUCOMA OR OCULAR HYPERTENSION WITH AN ADENOSINE DERIVATIVE
  申请人：SANTEN PHARMACEUTICAL CO., LTD.

  公开号：US20130109646A1

  公开（公告）日：2013-05-02

  A method for treating glaucoma or ocular hypertension by administering to a patient a pharmacologically effective amount of a compound represented by the following formula (1) or a salt thereof: , wherein X represents CH or N; R 1 represents a hydrogen atom, a hydroxy group, a halogen atom, an alkyl group, an alkoxy group, a cycloalkyl group, a cycloalkoxy group, a (cycloalkyl)alkoxy group, or R 2 represents a hydrogen atom, an alkyl group, a cycloalkyl group, an alkylcarbonyl group or an alkyloxycarbonyl group; and R a and R b each represent a hydrogen atom, a hydroxy group, a halogen atom, an alkyl group, an alkoxy group, a cycloalkyl group or a cycloalkoxy group.
• US8252767B2
  申请人：——

  公开号：US8252767B2

  公开（公告）日：2012-08-28
• US8293720B2
  申请人：——

  公开号：US8293720B2

  公开（公告）日：2012-10-23