3'-脱氧腺苷5'-三磷酸酯 | 73-04-1

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷酸
• 中文名称: 3'-脱氧腺苷5'-三磷酸酯
• 英文名称: cordycepin triphosphate
• 英文别名: 3'-dATP；3'-Deoxy-ATP；3’-dATP；3'-deoxy-adenosine triphosphate；3'-deoxyadenosine 5'-triphosphate；3′-dATP；[[(2S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate
• CAS: 73-04-1
• 化学式: C₁₀H₁₆N₅O₁₂P₃
• 分子量: 491.185
• InChiKey: NLIHPCYXRYQPSD-BAJZRUMYSA-N

物化性质

• 沸点：
  913.3±75.0 °C(Predicted)
• 密度：
  2.51±0.1 g/cm3(Predicted)
• 溶解度：
  甲醇（微溶）、水（微溶）

计算性质

• 辛醇/水分配系数(LogP)：
  -4.5
• 重原子数：
  30
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  259
• 氢给体数：
  6
• 氢受体数：
  16

反应信息

• 作为反应物：
  描述：

  3'-脱氧腺苷5'-三磷酸酯 生成 [[(2S,4R,5R)-5-(6-aminopurin-9-yl)-4-[[(2S,4R,5R)-5-(6-aminopurin-9-yl)-4-[[(2S,4R,5R)-5-(6-aminopurin-9-yl)-4-[[(2S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate
  参考文献：
  名称：

  SUHADOLNIK, R. J.;WU, J. M.;DOETSCH, P.;HENDERSON, E. E.

  摘要：

  DOI：
• 作为产物：
  描述：

  3'-脱氧肌苷 生成 3'-脱氧腺苷5'-三磷酸酯
  参考文献：
  名称：

  WATAYA, Y.;HIRAOKA, O.;SONOBE, Y.;YOSHIOKA, A.;MATSUDA, A.;MIYASAKA, T.;S+, 12TH SYMP. NUCL. ACIDS CHEM., KANAZAWA, OCT. 30-NOV. I, 1984, OXFORD; WAS+

  摘要：

  DOI：

文献信息

• [EN] COMPOSITIONS AND METHODS FOR ALTERING SECOND MESSENGER SIGNALING<br/>[FR] COMPOSITIONS ET PROCÉDÉS POUR ALTÉRER LA SIGNALISATION PAR UN SECOND MESSAGER
  申请人：SLOAN KETTERING INST CANCER

  公开号：WO2014179335A1

  公开（公告）日：2014-11-06

  The invention relates to compositions, methods, kits, and assays related to the use and/or exploitation of isomers of cGAMP as well as the structure of the enzyme cGAS.

  这项发明涉及到与使用和/或利用cGAMP同分异构体以及酶cGAS的结构相关的组合物、方法、试剂盒和测定方法。
• Real-time linear detection probes: sensitive 5'-minor groove binder-containing probes for PCR analysis
  申请人：Epoch Biosciences, Inc.

  公开号：US20030175728A1

  公开（公告）日：2003-09-18

  Oligonucleotide probes/conjugates are provided along with method for their use in assays to monitor amplification wherein the signal produced does not rely on 5′ nuclease digestion.

  提供了寡核苷酸探针/共轭物，并提供了它们在检测扩增过程中的使用方法，其中产生的信号不依赖于5'核酸酶消化。
• [EN] NEW 2' AND/OR 5' AMINO-ACID ESTER PHOSPHORAMIDATE 3'-DEOXY ADENOSINE DERIVATIVES AS ANTI-CANCER COMPOUNDS<br/>[FR] NOUVEAUX DÉRIVÉS DE 3'-DÉSOXYADÉNOSINE PRÉSENTANT UN FRAGMENT ESTER DE PHOSPHORAMIDATE ET D'ACIDE AMINÉ 2' ET/OU 5' COMME COMPOSÉS ANTICANCÉREUX
  申请人：NUCANA BIOMED LTD

  公开号：WO2016083830A1

  公开（公告）日：2016-06-02

  The present invention relates to chemical compounds, the compounds for use in a method of treatment, particularly in a method of prophylaxis or treatment for cancer, a process for preparation of the compounds and pharmaceutical compositions comprising the compounds. The compounds may, in particular, be useful in the treatment of leukaemia, lymphoma and/or solid tumours inhomo sapiens. The compounds are derivatives of cordycepin (3'-deoxyadenosine) having a 2' and/or 5'- amino-acid ester phosphoramidate moeity.

  本发明涉及化合物，这些化合物用于治疗方法，特别是用于癌症的预防或治疗方法，以及制备这些化合物的过程和包含这些化合物的药物组合物。这些化合物可能特别适用于治疗人类的白血病、淋巴瘤和/或实体肿瘤。这些化合物是科迪西平（3'-去氧腺苷）的衍生物，具有2'和/或5'-氨基酸酯磷酰胺基团。
• Therapeutic azide compounds
  申请人：University of Georgia Research Foundation, Inc.

  公开号：US20010036930A1

  公开（公告）日：2001-11-01

  Pharmaceutical prodrug compositions are provided comprising azide derivatives of drugs which are capable of being converted to the drug in vivo. Azide derivatives of drugs having amine, ketone and hydroxy substituents are converted in vivo to the corresponding drugs, increasing the half-life of the drugs. In addition azide prodrugs are often better able to penetrate the blood-brain barrier than the corresponding drugs. Especially useful are azide derivatives of cordycepin, 2′-F-ara-ddI, AraA, acyclovir, penciclovir and related drugs. Useful azide prodrugs are azide derivatives of therapeutic alicyclic amines, ketones, and hydroxy-substituted compounds, including aralkyl, heterocyclic aralkyl, and cyclic aliphatic compounds, where the amine or oxygen moiety is on the ring, or where the amine or oxygen moiety is on an aliphatic side chain, as well as therapeutic purines and pyrimidines, nucleoside analogs and phosphorylated nucleoside analogs.

  提供了药物前药组成物，其中包括具有可在体内转化为药物的药物的偶氮衍生物。具有胺基，酮基和羟基取代基的药物的偶氮衍生物在体内转化为相应的药物，增加了药物的半衰期。此外，偶氮前药通常比相应的药物更能穿过血脑屏障。特别有用的是cordycepin，2'-F-ara-ddI，AraA，acyclovir，penciclovir和相关药物的偶氮衍生物。有用的偶氮前药是治疗性脂环烷胺，酮和羟基取代化合物的偶氮衍生物，包括芳基烷基，杂环芳基烷基和环状脂肪族化合物，其中胺基或氧原子基团位于环上，或胺基或氧原子基团位于脂肪侧链上，以及治疗性嘌呤和嘧啶，核苷类似物和磷酸化核苷类似物。
• A method for the amplification of nucleotide sequences
  申请人：ZENECA LIMITED

  公开号：EP0356021A2

  公开（公告）日：1990-02-28

  A method for the amplification of a nucleic acid fragment containing unknown sequence and kits therefor are provided which enable long nucleotide sequences to be rapidly and efficiently sequenced. The method comprises the formation of target nucleic acid fragment/vectorette units by cleavage of target nucleic acid followed by ligation. One of the nucleic acid fragments will contain an initiating priming region of known sequence for hybridisation with-an initiating primer and target nucleic acid fragment/vectorette units will contain a vectorette priming region of known sequence for hybridisation with a vectorette primer. Amplification is effected by primer extension of an initiating primer hybridised to the initiating priming region of the target nucleic acid fragment/vectorette unit.

  本发明提供了一种扩增含有未知序列的核酸片段的方法及其试剂盒，可快速有效地对长核苷酸序列进行测序。该方法包括通过裂解目标核酸形成目标核酸片段/外显子单元，然后进行连接。其中一个核酸片段将包含已知序列的起始引物区，用于与起始引物杂交；目标核酸片段/外显子单元将包含已知序列的外显子引物区，用于与外显子引物杂交。扩增是通过与目标核酸片段/外显子单元的起始引物区杂交的起始引物延伸来实现的。