Ethyl 2-(2-triethoxysilylethyl)cyclohexene-1-carboxylate | 1448675-37-3

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: Ethyl 2-(2-triethoxysilylethyl)cyclohexene-1-carboxylate
• 英文别名: ethyl 2-(2-triethoxysilylethyl)cyclohexene-1-carboxylate
• CAS: 1448675-37-3
• 化学式: C₁₇H₃₂O₅Si
• 分子量: 344.524
• InChiKey: MDPXPFKJLKKIIZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.86
• 重原子数：
  23
• 可旋转键数：
  12
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  54
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  1-环己烯羧酸乙酯 、 乙烯基三乙氧基硅烷 在 RuH₂(CO)(PPh₃)₃ 作用下， 以 甲苯 为溶剂， 反应 20.0h， 生成 Ethyl 2-(2-triethoxysilylethyl)cyclohexene-1-carboxylate
  参考文献：
  名称：

  SYNTHESIS OF A NEW OSELTAMIVIR DERIVATIVE THROUGH LATE-STAGE CATALYTIC C–H FUNCTIONALIZATION

  摘要：

  N-Boc-protected oseltamivir 5 was converted to olefin insertion product 4 via a ruthenium-catalyzed C(sp(2))-H functionalization reaction using its ester functionality as a directing group. The addition of a catalytic amount of (p-CF3C6H4)(3)P in the presence of the RuH2(CO)(PPh3)(3) catalyst significantly improved the yield for this specific conversion. Tamao-Fleming oxidation followed by deprotection concisely produced a new oseltamivir analog 16.

  DOI：

  10.3987/com-12-s(n)94

文献信息

• SYNTHESIS OF A NEW OSELTAMIVIR DERIVATIVE THROUGH LATE-STAGE CATALYTIC C–H FUNCTIONALIZATION
  作者：Motomu Kanai、Kenta Saito

  DOI：10.3987/com-12-s(n)94

  日期：——

  N-Boc-protected oseltamivir 5 was converted to olefin insertion product 4 via a ruthenium-catalyzed C(sp(2))-H functionalization reaction using its ester functionality as a directing group. The addition of a catalytic amount of (p-CF3C6H4)(3)P in the presence of the RuH2(CO)(PPh3)(3) catalyst significantly improved the yield for this specific conversion. Tamao-Fleming oxidation followed by deprotection concisely produced a new oseltamivir analog 16.