Ni(N-2-hydroxyacetophenon-N'-2-hydroxynaphthaldehyde-1,2-phenylenediimine) | 82312-69-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: Ni(N-2-hydroxyacetophenon-N'-2-hydroxynaphthaldehyde-1,2-phenylenediimine)
• 英文别名: N,N'-o-phenylene(2-hydroxy-1-naphthaldehdato, 1-(2-hydroxy phenyl) ethylideneaminato)Ni(II)
• CAS: 82312-69-4
• 化学式: C₂₅H₁₈N₂NiO₂
• 分子量: 437.12
• InChiKey: PVUWDBPWEXRTDY-JCJDGKGVSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
  None

反应信息

• 作为产物：
  描述：

  2-ethanimidoylphenolate;1-methanimidoylnaphthalen-2-olate;nickel(2+) 、 邻苯二胺 以 乙醇 为溶剂， 生成 Ni(N-2-hydroxyacetophenon-N'-2-hydroxynaphthaldehyde-1,2-phenylenediimine)
  参考文献：
  名称：

  Thaker B. T., Journal of the Indian Chemical Society, 1984, vol. 61, p. 260 - 262

  摘要：

  DOI：

文献信息

• Sharma, R. P.; Prasad, R. N., Synthesis and Reactivity in Inorganic and Metal-Organic Chemistry, 1982, vol. 12, p. 347 - 360
  作者：Sharma, R. P.、Prasad, R. N.

  DOI：——

  日期：——
• Synthesis and electronic structure of novel Schiff bases Ni/Cu (II) complexes: Evaluation of DNA/serum protein binding by spectroscopic studies
  作者：Maryam Sedighipoor、Ali Hossein Kianfar、Wan Ahmad Kamil Mahmood、Mohammad Hossein Azarian

  DOI：10.1016/j.poly.2017.03.027

  日期：2017.6

  [Cu(L)] (1) and [Ni(L)] (2) [L = N-2-hydroxyacetophenon-N'-2-hydroxynaphthaldehyde-1,2 phenylenediimine)], Schiff base complexes have been successfully synthesized. Single crystal X-ray crystallography, Fourier Transform infrared spectroscopy (FT-IR), NMR spectroscopy and elemental analysis (EA) have been used to characterize the complexes. Complex 1 shows unsymmetrical ligand coordination to copper (II) ion in a tetradentate fashion through ONNO donor atoms according to single crystal X-ray patterns. Spectroscopic methods have been used to study the interactions between the synthesized Schiff base complexes and Calf Thymus DNA (CT-DNA) and Bovine Serum Albumin (BSA) under physiological conditions. UV-vis absorption, fluorescence, and circular dichroism (CD) spectroscopy and thermal denaturation measurements were used in the investigation of DNA binding properties of these two complexes. The two complexes can bind to Calf Thymus DNA (CT-DNA) via an intercalative mode and complex 1 exhibits stronger interaction with CT-DNA compared with complex 2 based on the results. In addition, both compounds interact with BSA to change its microenvironment during interaction. Cu (II) complex has more affinity for BSA based on the quenching (K-sv) and binding constant (K-b) values of both compounds with BSA. Circular Dichroism technique has been applied to investigate the conformational changes of the interactions of metal complexes with DNA. Also thermal behavior of DNA-complex interaction has been determined. (C) 2017 Elsevier Ltd. All rights reserved.