Methyl 3-(1-methoxycarbonylindolizin-3-yl)indolizine-1-carboxylate | 1089206-42-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯并吡啶类
• 英文名称: Methyl 3-(1-methoxycarbonylindolizin-3-yl)indolizine-1-carboxylate
• CAS: 1089206-42-7
• 化学式: C₂₀H₁₆N₂O₄
• 分子量: 348.358
• InChiKey: SYOQMQNDOGBORQ-UHFFFAOYSA-N

物化性质

• 熔点：
  213-215 °C
• 密度：
  1.30±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  61.4
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  中氮茚-1-甲酸甲酯 在 copper diacetate 、 palladium diacetate 、 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 2.0h， 以99%的产率得到Methyl 3-(1-methoxycarbonylindolizin-3-yl)indolizine-1-carboxylate
  参考文献：
  名称：

  Synthesis of Biindolizines through Highly Regioselective Palladium-Catalyzed C−H Functionalization

  摘要：

  Biindolizines were synthesized under mild conditions with excellent regioselectivity in high yields through palladium-catalyzed C-H functionalization of indolizines. Synthesis of a macrocyclic compound was also achieved via intramolecular double C-H functionalization.

  DOI：

  10.1021/jo802227u

文献信息

• Synthesis of Biindolizines through Highly Regioselective Palladium-Catalyzed C−H Functionalization
  作者：Ji-Bao Xia、Xue-Qiang Wang、Shu-Li You

  DOI：10.1021/jo802227u

  日期：2009.1.2

  Biindolizines were synthesized under mild conditions with excellent regioselectivity in high yields through palladium-catalyzed C-H functionalization of indolizines. Synthesis of a macrocyclic compound was also achieved via intramolecular double C-H functionalization.