1-Benzyl-3-[(3-hydroxynaphthalene-2-carbonyl)amino]thiourea | 219538-18-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1-Benzyl-3-[(3-hydroxynaphthalene-2-carbonyl)amino]thiourea
• CAS: 219538-18-8
• 化学式: C₁₉H₁₇N₃O₂S
• 分子量: 351.429
• InChiKey: SFRUUOXPAHEPHP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  106
• 氢给体数：
  4
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-Benzyl-3-[(3-hydroxynaphthalene-2-carbonyl)amino]thiourea 在 sodium hydroxide 、 水 作用下， 反应 2.5h， 以94.37%的产率得到3-(4-Benzyl-5-mercapto-4H-1,2,4-triazol-3-yl)naphthalen-2-ol
  参考文献：
  名称：

  Synthesis, structure elucidation and antimicrobial activity of some 3-hydroxy-2-naphthoic acid hydrazide derivatives

  摘要：

  In this study, some 1,4-disubstituted thiosemicarbazide, 1,2,4-triazole and 1,3,4-thiadiazole type novel compounds derived from 3-hydroxy-2-naphthoic acid hydrazide were synthesized to screen for their antimicrobial activity. The structures of these substances were elucidated using elemental analysis and UV, H-1 NMR, and mass spectral methods. All of these compounds were tested in vitro for their antibacterial and antifungal activity. (C) 1998 Elsevier Science S.A. All rights reserved.

  DOI：

  10.1016/s0014-827x(98)00049-4
• 作为产物：
  描述：

  异硫氰酸苯甲酯 、 3-羟基-2-萘酸肼 以 乙醇 为溶剂， 反应 3.0h， 以90.91%的产率得到1-Benzyl-3-[(3-hydroxynaphthalene-2-carbonyl)amino]thiourea
  参考文献：
  名称：

  Synthesis, structure elucidation and antimicrobial activity of some 3-hydroxy-2-naphthoic acid hydrazide derivatives

  摘要：

  In this study, some 1,4-disubstituted thiosemicarbazide, 1,2,4-triazole and 1,3,4-thiadiazole type novel compounds derived from 3-hydroxy-2-naphthoic acid hydrazide were synthesized to screen for their antimicrobial activity. The structures of these substances were elucidated using elemental analysis and UV, H-1 NMR, and mass spectral methods. All of these compounds were tested in vitro for their antibacterial and antifungal activity. (C) 1998 Elsevier Science S.A. All rights reserved.

  DOI：

  10.1016/s0014-827x(98)00049-4

文献信息

• Synthesis, structure elucidation and antimicrobial activity of some 3-hydroxy-2-naphthoic acid hydrazide derivatives
  作者：H.N. Dogan、S. Rollas、H. Erdeniz

  DOI：10.1016/s0014-827x(98)00049-4

  日期：1998.7

  In this study, some 1,4-disubstituted thiosemicarbazide, 1,2,4-triazole and 1,3,4-thiadiazole type novel compounds derived from 3-hydroxy-2-naphthoic acid hydrazide were synthesized to screen for their antimicrobial activity. The structures of these substances were elucidated using elemental analysis and UV, H-1 NMR, and mass spectral methods. All of these compounds were tested in vitro for their antibacterial and antifungal activity. (C) 1998 Elsevier Science S.A. All rights reserved.