(3-methyl-4-{3-[(pyridin-3-ylmethyl)-amino]-propoxy}-benzofuran-2-yl)-pyridin-2-yl-methanol | 279231-39-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并呋喃
• 英文名称: (3-methyl-4-{3-[(pyridin-3-ylmethyl)-amino]-propoxy}-benzofuran-2-yl)-pyridin-2-yl-methanol
• 英文别名: [3-Methyl-4-[3-(pyridin-3-ylmethylamino)propoxy]-1-benzofuran-2-yl]-pyridin-2-ylmethanol
• CAS: 279231-39-9
• 化学式: C₂₄H₂₅N₃O₃
• 分子量: 403.481
• InChiKey: FJGCNQALXGWFCZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  30
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  80.4
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  (3-methyl-4-{3-[(pyridin-3-ylmethyl)-amino]-propoxy}-benzofuran-2-yl)-pyridin-2-yl-methanol 生成 {3-[2-(hydroxy-pyridin-2-yl-methyl)-3-methyl-benzofuran-4-yloxy]-propyl}-pyridin-3-ylmethyl-carbamic acid tert-butyl ester
  参考文献：
  名称：

  Bicyclic compounds

  摘要：

  本发明涉及公式［I］的新的双环化合物及其药学上可接受的盐，其中R1、R2、R3、R4、R5、R6、R7、Q1、Q2和Q3如权利要求中所定义。这些化合物具有N-肉豆蔻酰基转移酶抑制和抗真菌活性。

  公开号：

  US06376491B1
• 作为产物：
  描述：

  4-(3-bromopropoxy)-3-methylbenzofuran-2-carboxylic acid ethyl ester 在 氢氧化钾 、 sodium tetrahydroborate 、 正丁基锂 、 草酰氯 、 三氟乙酸 作用下， 以 甲醇 、 乙醇 、 二氯甲烷 为溶剂， 生成 (3-methyl-4-{3-[(pyridin-3-ylmethyl)-amino]-propoxy}-benzofuran-2-yl)-pyridin-2-yl-methanol
  参考文献：
  名称：

  Design and synthesis of novel benzofurans as a new class of antifungal agents targeting fungal N-myristoyltransferase. Part 3

  摘要：

  A new series of acid-stable antifungal agents having strong inhibitory activity against Candida albicans N-myristoyl-transferase (CaNmt) has been developed starting from acid-unstable benzofuranylmethyl aryl ether 2. The inhibitor design is based on X-ray crystallographic analysis of a CaNmt complex with aryl ether 3. Among the new inhibitors, pyridine derivative 8b and benzimidazole derivative 8k showed clear antifungal activity in a murine systemic candidiasis model. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)00844-2

文献信息

• 4-(AMINOALKOXY)BENZOFURANS AS N-MYRISTOYLTRANSFERASE INHIBITORS
  申请人：Basilea Pharmaceutica AG

  公开号：EP1149094B1

  公开（公告）日：2004-04-21
• US6376491B1
  申请人：——

  公开号：US6376491B1

  公开（公告）日：2002-04-23
• [EN] NOVEL BICYCLIC COMPOUNDS<br/>[FR] NOUVEAUX COMPOSES BICYCLIQUES
  申请人：HOFFMANN LA ROCHE

  公开号：WO2000037464A2

  公开（公告）日：2000-06-29

  The present invention is directed to new bicyclic compounds of formula (I), and pharmaceutically acceptable salts thereof wherein R?1, R2, R3, R4, R5, R6, R7, Q1 Q2 and Q3¿ are as defined in the claims. The compounds have N-myristoyltransferase inhibitory and antifungal activity.
• Bicyclic compounds
  申请人：Basilea Pharmaceutica AG

  公开号：US06376491B1

  公开（公告）日：2002-04-23

  The present invention is directed to new bicyclic compounds of the formula [I], and pharmaceutically acceptable salts thereof wherein R1, R2, R3, R4, R5, R6, R7, Q1 Q2 and Q3 are as defined in the claims. The compounds have N-myristoyltransferase inhibitory and antifungal activity.

  本发明涉及公式［I］的新的双环化合物及其药学上可接受的盐，其中R1、R2、R3、R4、R5、R6、R7、Q1、Q2和Q3如权利要求中所定义。这些化合物具有N-肉豆蔻酰基转移酶抑制和抗真菌活性。
• Design and synthesis of novel benzofurans as a new class of antifungal agents targeting fungal N-myristoyltransferase. Part 3
  作者：Ken-ichi Kawasaki、Miyako Masubuchi、Kenji Morikami、Satoshi Sogabe、Tsunehisa Aoyama、Hirosato Ebiike、Satoshi Niizuma、Michiko Hayase、Toshihiko Fujii、Kiyoaki Sakata、Hidetoshi Shindoh、Yasuhiko Shiratori、Yuko Aoki、Tatsuo Ohtsuka、Nobuo Shimma

  DOI：10.1016/s0960-894x(02)00844-2

  日期：2003.1

  A new series of acid-stable antifungal agents having strong inhibitory activity against Candida albicans N-myristoyl-transferase (CaNmt) has been developed starting from acid-unstable benzofuranylmethyl aryl ether 2. The inhibitor design is based on X-ray crystallographic analysis of a CaNmt complex with aryl ether 3. Among the new inhibitors, pyridine derivative 8b and benzimidazole derivative 8k showed clear antifungal activity in a murine systemic candidiasis model. (C) 2002 Elsevier Science Ltd. All rights reserved.