(8-Iodo-7-methylphenazin-2-yl)dimethylamine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: (8-Iodo-7-methylphenazin-2-yl)dimethylamine
• 英文别名: 8-iodo-N,N,7-trimethylphenazin-2-amine
• 化学式: C₁₅H₁₄IN₃
• 分子量: 363.201
• InChiKey: HUIFBPFNRAYAKM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  19
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  29
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  N',N',3-三甲基吩嗪-2,8-二胺 在 盐酸 、 sodium nitrite 、 potassium iodide 作用下， 以70%的产率得到(8-Iodo-7-methylphenazin-2-yl)dimethylamine
  参考文献：
  名称：

  Hepatitis C viral IRES inhibition by phenazine and phenazine-like molecules

  摘要：

  An in vitro assay based on the expression of Fluci reporter gene under the translational control of HCV IRES was used to evaluate and screen compound libraries. A structure-activity relationship study on a phenazine kit was conducted. Our data suggest that an intact phenazine or phenazine-like core with two distal polar substitutions is crucial for potency. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(00)00217-1

文献信息

• Hepatitis C viral IRES inhibition by phenazine and phenazine-like molecules
  作者：Wuyi Wang、Patrice Préville、Nicolas Morin、Samir Mounir、Weizhong Cai、M.Arshad Siddiqui

  DOI：10.1016/s0960-894x(00)00217-1

  日期：2000.6

  An in vitro assay based on the expression of Fluci reporter gene under the translational control of HCV IRES was used to evaluate and screen compound libraries. A structure-activity relationship study on a phenazine kit was conducted. Our data suggest that an intact phenazine or phenazine-like core with two distal polar substitutions is crucial for potency. (C) 2000 Elsevier Science Ltd. All rights reserved.