N-<2-(2-thienyl)ethyl>glutarimide | 93447-70-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: N-<2-(2-thienyl)ethyl>glutarimide
• 英文别名: 1-(2-Thiophen-2-ylethyl)piperidine-2,6-dione
• CAS: 93447-70-2
• 化学式: C₁₁H₁₃NO₂S
• 分子量: 223.296
• InChiKey: YJEAWTVFPMCSDJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  65.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-<2-(2-thienyl)ethyl>glutarimide 在 sodium tetrahydroborate 作用下， 以 甲醇 为溶剂， 反应 2.0h， 以84%的产率得到6-hydroxy-1-<2-(2-thienyl)ethyl>piperidin-2-one
  参考文献：
  名称：

  Meth-Cohn, Otto; Vij, Rup Rani; Smalley, Robert K., Journal of Chemical Research, Miniprint, 1989, # 5, p. 1001 - 1018

  摘要：

  DOI：
• 作为产物：
  描述：

  噻吩乙胺 、 戊二酸 反应 4.0h， 以29%的产率得到N-<2-(2-thienyl)ethyl>glutarimide
  参考文献：
  名称：

  Meth-Cohn, Otto; Vij, Rup Rani; Smalley, Robert K., Journal of Chemical Research, Miniprint, 1989, # 5, p. 1001 - 1018

  摘要：

  DOI：

文献信息

• GLUTARIMIDE DERIVATIVES, USE THEREOF, PHARMACEUTICAL COMPOSITION BASED THEREON AND METHODS FOR PRODUCING GLUTARIMIDE DERIVATIVES
  申请人：Obschestvo S Ogranichennoi Otvetstennostiyu "Pharmenterprises"

  公开号：EP2985282A1

  公开（公告）日：2016-02-17

  The present invention relates to novel biologically active glutarimide derivatives of general formula I or pharmaceutically acceptable salts thereof, their use as an agent for the treatment of upper respiratory tract diseases, pharmaceutical compositions comprising the glutarimide derivatives of general formula I, methods for preparing the glutarimide derivatives of general formula I by heating a dicarboxylic acid monoamide of general formula II with a dehydrating agent.

  本发明涉及通式Ⅰ的新型生物活性戊二酰亚胺衍生物或其药学上可接受的盐、它们作为治疗上呼吸道疾病的制剂的用途、包含通式Ⅰ的戊二酰亚胺衍生物的药物组合物、通过用脱水剂加热通式Ⅱ的二羧酸单酰胺来制备通式Ⅰ的戊二酰亚胺衍生物的方法。
• Glutarimide derivatives, use thereof, pharmaceutical composition based thereon and methods for producing glutarimide derivatives
  申请人：OBSCHESTVO S OGRANICHENNOI OTVETSTVENNOSTIYU “PHARMENTERPRISES”

  公开号：US10196377B2

  公开（公告）日：2019-02-05

  A compound having the following formula: or a pharmaceutically acceptable salt thereof. A medicament or pharmaceutical composition contains the compound. A method of treating a respiratory tract disease includes administering to a patient an effective amount of a compound or a pharmaceutically acceptable salt thereof.

  具有下式的化合物 或其药学上可接受的盐。药物或药物组合物含有该化合物。一种治疗呼吸道疾病的方法包括向患者施用有效量的化合物或其药学上可接受的盐。
• METH-COHN, OTTO;VIJ, RUP RANI;SMALLEY, ROBERT K.;BASS, ROBERT, J. CHEM. RES. (S),(1989) N, C. 124-125
  作者：METH-COHN, OTTO、VIJ, RUP RANI、SMALLEY, ROBERT K.、BASS, ROBERT

  DOI：——

  日期：——
• Glutarimide Derivatives, Use Thereof, Pharmaceutical Composition Based Thereon and Methods for Producing Glutarimide Derivatives
  申请人：OBSCHESTVO S OGRANICHENNOI OTVETSTVENNOSTIYU "PHARMENTERPRISES"

  公开号：US20180016255A1

  公开（公告）日：2018-01-18

  A medicament or pharmaceutical composition for the treatment of exacerbations of asthma and chronic obstructive pulmonary disease, which is a compound having the following formula: or a pharmaceutically acceptable salt thereof. A method of treating exacerbations of asthma and chronic obstructive pulmonary disease includes administering to a patient an effective amount of the compound or a pharmaceutically acceptable salt thereof.
• US9815814B2
  申请人：——

  公开号：US9815814B2

  公开（公告）日：2017-11-14