(1R,2R)-N-[2-(2,2-dimethyl-propylamino)-1,2-diphenyl-ethyl]-4-methyl-benzenesulfonamide | 1043450-06-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: (1R,2R)-N-[2-(2,2-dimethyl-propylamino)-1,2-diphenyl-ethyl]-4-methyl-benzenesulfonamide
• 英文别名: N-[(1R,2R)-2-(2,2-dimethylpropylamino)-1,2-diphenylethyl]-4-methylbenzenesulfonamide
• CAS: 1043450-06-1
• 化学式: C₂₆H₃₂N₂O₂S
• 分子量: 436.618
• InChiKey: KJHXTTWWBUHFSR-JWQCQUIFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  31
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  66.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  特戊醛 、 (1R,2R)-(-)-N-(对甲基苯磺酰基)-1,2-二苯基乙二胺 在 molecular sieve 、 溶剂黄146 、 sodium cyanoborohydride 作用下， 以 甲醇 为溶剂， 反应 4.0h， 以77%的产率得到(1R,2R)-N-[2-(2,2-dimethyl-propylamino)-1,2-diphenyl-ethyl]-4-methyl-benzenesulfonamide
  参考文献：
  名称：

  Synthesis of a series of novel N,N-dialkyl-TsDPEN ligands and their application to enantioselective addition of dialkylzinc to benzaldehyde

  摘要：

  A series of mono- and dialkylated derivatives of C2-symmetric N-tosyl-1,2-diphenylethylene diamines have been prepared and used as ligands for the enantiomeric control of the addition of diethylzinc to aldehydes. Addition products of up to 79% ee were formed. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2008.04.020

文献信息

• Synthesis of a series of novel N,N-dialkyl-TsDPEN ligands and their application to enantioselective addition of dialkylzinc to benzaldehyde
  作者：José E.D. Martins、Martin Wills

  DOI：10.1016/j.tetasy.2008.04.020

  日期：2008.5

  A series of mono- and dialkylated derivatives of C2-symmetric N-tosyl-1,2-diphenylethylene diamines have been prepared and used as ligands for the enantiomeric control of the addition of diethylzinc to aldehydes. Addition products of up to 79% ee were formed. (C) 2008 Elsevier Ltd. All rights reserved.