3-羟基-2-[1]萘基-3,3-二苯基-丙酸 | 115293-30-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 中文名称: 3-羟基-2-[1]萘基-3,3-二苯基-丙酸
• 英文名称: 3-hydroxy-2-[1]naphthyl-3,3-diphenyl-propionic acid
• 英文别名: 3-Hydroxy-2-[1]naphthyl-3,3-diphenyl-propionsaeure
• CAS: 115293-30-6
• 化学式: C₂₅H₂₀O₃
• 分子量: 368.432
• InChiKey: ATRPOEHDBBOJBS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.94
• 重原子数：
  28.0
• 可旋转键数：
  5.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  57.53
• 氢给体数：
  2.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  3-羟基-2-[1]萘基-3,3-二苯基-丙酸 在 三氯氧磷 、 苯 作用下， 生成 6-phenylchrysene
  参考文献：
  名称：

  Ivanoff, Doklady Bolgarskoi Akademii Nauk, 1954, vol. 7, # 1, p. 29

  摘要：

  DOI：
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 propyllithium 作用下， 生成 3-羟基-2-[1]萘基-3,3-二苯基-丙酸
  参考文献：
  名称：

  Panajotoff; Borissoff, Doklady Bolgarskoi Akademii Nauk, 1956, vol. 9, # 1, p. 27,29

  摘要：

  DOI：

文献信息

• Study of the family of a patient with male-limited precocious puberty (MPP) due to T1193C transition in exon 11 of LH receptor gene
  作者：M. Ignacak、J. Starzyk、H. Dziatkowiak、W. H. Trzeciak

  DOI：10.1007/bf03344001

  日期：2002.3

  Molecular diagnostics of the LHR gene was conducted in a 5-year-old boy with clinical symptoms and hormonal profile typical of precocious puberty. His parents and 4 sisters were also diagnosed. Single-strand conformation polymorphism analysis under temperature gradient conditions (Multitemperature SSCP) of 3 overlapping fragments of exon 11 of LHR gene revealed a mutation in the fragment spanning nucleotides 1072 to 1804. This mutation was found in the patient, in his mother and in his 4 sisters, and was confirmed by digestion with the use of restriction enzyme Bbr Cl. Direct sequencing revealed a heterozygous T1193C transition in the DNA fragment of the patient and in one of the alleles of his mother's and sister's DNA. This mutation causes Met398Thr substitution in the second transmembrane helix and results in a constitutive activation of LH receptor. This is the second identical mutation detected in Poland and one of the 7 identified so far in the world population.