2-Amino-N-(1-benzyl-piperidin-4-ylmethyl)-acetamide | 757236-90-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 2-Amino-N-(1-benzyl-piperidin-4-ylmethyl)-acetamide
• 英文别名: 2-amino-N-[(1-benzylpiperidin-4-yl)methyl]acetamide
• CAS: 757236-90-1
• 化学式: C₁₅H₂₃N₃O
• 分子量: 261.367
• InChiKey: SRNZTJJGKJEUNF-UHFFFAOYSA-N

物化性质

• 沸点：
  445.8±25.0 °C(Predicted)
• 密度：
  1.091±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  58.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  9-氯-1,2,3,4-四氢吖啶 、 2-Amino-N-(1-benzyl-piperidin-4-ylmethyl)-acetamide 以 戊醇 为溶剂， 以76.9%的产率得到N-[(1-benzylpiperidin-4-yl)methyl]-2-(1,2,3,4-tetrahydroacridin-9-ylamino)acetamide
  参考文献：
  名称：

  Synthesis and evaluation of tacrine–E2020 hybrids as acetylcholinesterase inhibitors for the treatment of Alzheimer’s disease

  摘要：

  Tacrine-E2020 hybrids and some related compounds were prepared and their bioactivities on the Alzheimer's disease were assayed. The optimum hybrid inhibitor 3 is 37-fold more potent and 31-fold more selective than tacrine in vitro. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.07.005
• 作为产物：
  描述：

  1-苄基哌啶-4-甲胺 在 三氟乙酸 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 生成 2-Amino-N-(1-benzyl-piperidin-4-ylmethyl)-acetamide
  参考文献：
  名称：

  Synthesis and evaluation of tacrine–E2020 hybrids as acetylcholinesterase inhibitors for the treatment of Alzheimer’s disease

  摘要：

  Tacrine-E2020 hybrids and some related compounds were prepared and their bioactivities on the Alzheimer's disease were assayed. The optimum hybrid inhibitor 3 is 37-fold more potent and 31-fold more selective than tacrine in vitro. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.07.005

文献信息

• Synthesis and evaluation of tacrine–E2020 hybrids as acetylcholinesterase inhibitors for the treatment of Alzheimer’s disease
  作者：Dong Shao、Chunyan Zou、Cheng Luo、Xican Tang、Yuanchao Li

  DOI：10.1016/j.bmcl.2004.07.005

  日期：2004.9

  Tacrine-E2020 hybrids and some related compounds were prepared and their bioactivities on the Alzheimer's disease were assayed. The optimum hybrid inhibitor 3 is 37-fold more potent and 31-fold more selective than tacrine in vitro. (C) 2004 Elsevier Ltd. All rights reserved.