2,6-bis(4-methylphenyl)-1-methyl-4-piperidone | 914295-44-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 2,6-bis(4-methylphenyl)-1-methyl-4-piperidone
• 英文别名: 1-methyl-2,6-bis(4-methylphenyl)piperidin-4-one
• CAS: 914295-44-6
• 化学式: C₂₀H₂₃NO
• 分子量: 293.409
• InChiKey: UNCXGXDYEIUDJW-UHFFFAOYSA-N

物化性质

• 熔点：
  155-157 °C
• 沸点：
  442.0±45.0 °C(Predicted)
• 密度：
  1.067±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2,6-bis(4-methylphenyl)-1-methyl-4-piperidone 在 双氧水 、 氢气 作用下， 以 甲醇 、 氯仿 为溶剂， 反应 6.0h， 生成 8-methyl-7,9-bis(4-methylphenyl)-1,2,4,8-tetraazaspiro[4.5]decan-3-thione
  参考文献：
  名称：

  Synthesis and study of antibacterial and antifungal activities of novel 8-methyl-7,9-diaryl-1,2,4,8-tetraazaspiro[4.5]decan-3-thiones

  摘要：

  Some novel spiropiperidinyl-1,2,4-triazolidin-3-thiones have been synthesized and studied for their antibacterial activity against Staphylococcus aureus, Bacillus subtilis, Escherichia coli and Pseudomonas aeruginosa and antifungal activity against Candida albicans, Candida-6, Candida-51, Aspergillus niger and Aspergillus flavus. Compounds 30-32 exhibited potent in vitro antibacterial activity against E. coli and P. aeruginosa whereas the same set of compounds exerted potent in vitro antifungal activity against Candida-6, A. niger and A. flavus. (c) 2005 Elsevier SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2005.02.001
• 作为产物：
  描述：

  对甲基苯甲醛 在 ammonium acetate 、 potassium carbonate 作用下， 以 乙醇 为溶剂， 反应 32.0h， 生成 2,6-bis(4-methylphenyl)-1-methyl-4-piperidone
  参考文献：
  名称：

  Synthesis and study of antibacterial and antifungal activities of novel 8-methyl-7,9-diaryl-1,2,4,8-tetraazaspiro[4.5]decan-3-thiones

  摘要：

  Some novel spiropiperidinyl-1,2,4-triazolidin-3-thiones have been synthesized and studied for their antibacterial activity against Staphylococcus aureus, Bacillus subtilis, Escherichia coli and Pseudomonas aeruginosa and antifungal activity against Candida albicans, Candida-6, Candida-51, Aspergillus niger and Aspergillus flavus. Compounds 30-32 exhibited potent in vitro antibacterial activity against E. coli and P. aeruginosa whereas the same set of compounds exerted potent in vitro antifungal activity against Candida-6, A. niger and A. flavus. (c) 2005 Elsevier SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2005.02.001

文献信息

• Cancer treatment using curcumin derivatives
  申请人：Vander Jagt L. David

  公开号：US20060276536A1

  公开（公告）日：2006-12-07

  Cancer or a precancerous condition is treated by administering a curcumin derivative to a subject.

  癌症或癌前病变可以通过向受试者施用姜黄素衍生物来治疗。
• Therapeutic curcumin derivatives
  申请人：Vander Jagt L. David

  公开号：US20070060644A1

  公开（公告）日：2007-03-15

  Curcumin analogues and methods are provided for treatment of disease.

  提供了类姜黄素和治疗疾病的方法。
• THERAPEUTIC CURCUMIN DERIVATIVES
  申请人：STC.UNM

  公开号：US20150011494A1

  公开（公告）日：2015-01-08

  Curcumin analogues and methods are provided for treatment of disease.

  提供了类姜黄素及其方法，用于治疗疾病。
• SELVARAJ, S.;MARAGATHASUNDARAM, S.;PERUMAL, S.;ARUMUGAM, N., INDIAN J. CHEM., 26,(1987) N 11, 1104-1105
  作者：SELVARAJ, S.、MARAGATHASUNDARAM, S.、PERUMAL, S.、ARUMUGAM, N.

  DOI：——

  日期：——
• US8841326B2
  申请人：——

  公开号：US8841326B2

  公开（公告）日：2014-09-23