4-[(7-chloro-3,4-dihydro-1,1-dioxido-3-oxo-2H-1,2,4-benzothiadiazin-2-yl)methyl]-N-cycloheptylpiperidine-1-carboxamide | 1373032-24-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻二嗪
• 英文名称: 4-[(7-chloro-3,4-dihydro-1,1-dioxido-3-oxo-2H-1,2,4-benzothiadiazin-2-yl)methyl]-N-cycloheptylpiperidine-1-carboxamide
• 英文别名: 4-[(7-chloro-1,1,3-trioxo-4H-1lambda6,2,4-benzothiadiazin-2-yl)methyl]-N-cycloheptylpiperidine-1-carboxamide；4-[(7-chloro-1,1,3-trioxo-4H-1λ6,2,4-benzothiadiazin-2-yl)methyl]-N-cycloheptylpiperidine-1-carboxamide
• CAS: 1373032-24-6
• 化学式: C₂₁H₂₉ClN₄O₄S
• 分子量: 469.005
• InChiKey: CCJCBHHCQBOHLR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  31
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  107
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  1-Boc-4-溴甲基哌啶 在 sodium hydride 、 N,N-二异丙基乙胺 作用下， 以 1,4-二氧六环 、 二氯甲烷 、 N,N-二甲基甲酰胺 、 mineral oil 为溶剂， 反应 14.17h， 生成 4-[(7-chloro-3,4-dihydro-1,1-dioxido-3-oxo-2H-1,2,4-benzothiadiazin-2-yl)methyl]-N-cycloheptylpiperidine-1-carboxamide
  参考文献：
  名称：

  Synthesis and evaluation of piperidine urea derivatives as efficacious 11β-hydroxysteroid dehydrogenase type 1 inhibitors in diabetic ob/ob mice

  摘要：

  11 beta-Hydroxysteroid dehydrogenase type 1 (11 beta-HSD1) has attracted considerable attention as a potential target for the treatment of diabetes and metabolic syndrome. Herein we report the design, synthesis and efficacy evaluation of novel amide and urea 11 beta-HSD1 inhibitors. Structure-activity relationship studies led to the identification of 10c, which was efficacious in a diabetic ob/ob mouse model and reduced fasting and non-fasting blood glucose levels after ip dosing. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.02.095

文献信息

• Synthesis and evaluation of piperidine urea derivatives as efficacious 11β-hydroxysteroid dehydrogenase type 1 inhibitors in diabetic ob/ob mice
  作者：Liming Zhang、Junhua Chen、Mengmeng Ning、Qingan Zou、Ying Leng、Jianhua Shen

  DOI：10.1016/j.bmcl.2012.02.095

  日期：2012.4

  11 beta-Hydroxysteroid dehydrogenase type 1 (11 beta-HSD1) has attracted considerable attention as a potential target for the treatment of diabetes and metabolic syndrome. Herein we report the design, synthesis and efficacy evaluation of novel amide and urea 11 beta-HSD1 inhibitors. Structure-activity relationship studies led to the identification of 10c, which was efficacious in a diabetic ob/ob mouse model and reduced fasting and non-fasting blood glucose levels after ip dosing. (C) 2012 Elsevier Ltd. All rights reserved.