7-azo-2-diethylaminooxazolo<4,5-b>pyridine | 147068-37-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶唑并吡啶类
• 英文名称: 7-azo-2-diethylaminooxazolo<4,5-b>pyridine
• 英文别名: (7-Azido-oxazolo[4,5-b]pyridin-2-yl)-diethyl-amine；7-azido-N,N-diethyl-[1,3]oxazolo[4,5-b]pyridin-2-amine
• CAS: 147068-37-9
• 化学式: C₁₀H₁₂N₆O
• 分子量: 232.245
• InChiKey: CTBWBYHUEQWFHL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  56.5
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  7-azo-2-diethylaminooxazolo<4,5-b>pyridine 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 、 乙醚 为溶剂， 反应 4.5h， 生成 ethyl 2-ethoxycarbonyl-3-<2-diethylaminooxazolo<4,5-b>pyridin-7-yl>aminopropenoate
  参考文献：
  名称：

  Synthesis of a Novel Oxazolo[4,5-f][1,6]naphthyridine

  摘要：

  7-Azo-2-diethylaminooxazolo-[4,5-b]pyridine (1) is converted in 5 steps to the novel oxazolo[4,5-f][1,6]naphthyridine-6-oxo-7-carboxylic acid 6.

  DOI：

  10.1080/00397919308012615
• 作为产物：
  描述：

  2-diethylaminooxazolo<4,5-b>pyridine 在 对甲苯磺酰叠氮 、 叔丁基锂 作用下， 生成 7-azo-2-diethylaminooxazolo<4,5-b>pyridine
  参考文献：
  名称：

  Oxazolo[4, 5-b]pyridines. Regioselective metalation of the 2-diethylaminooxazolo[4, 5-b]pyridine system and formation of 7-substituted derivatives

  摘要：

  Metalation of 2-diethylaminooxazolo[4,5-b]pyridine with tert-butyllithium occurs regioselectively in the 7-position of the heterocycle and the fused 2-dialkylaminooxazolo group thus functions as an ortho-directing group in this bicyclic system. Reaction of the resulting 7-lithio intermediate with electrophiles provides access to a variety of 7-substituted derivatives.

  DOI：

  10.1016/s0040-4039(00)60547-6

文献信息

• Oxazolo[4, 5-b]pyridines. Regioselective metalation of the 2-diethylaminooxazolo[4, 5-b]pyridine system and formation of 7-substituted derivatives
  作者：O. William Lever、Harvey M. Werblood、Ronald K. Russell

  DOI：10.1016/s0040-4039(00)60547-6

  日期：1993.1

  Metalation of 2-diethylaminooxazolo[4,5-b]pyridine with tert-butyllithium occurs regioselectively in the 7-position of the heterocycle and the fused 2-dialkylaminooxazolo group thus functions as an ortho-directing group in this bicyclic system. Reaction of the resulting 7-lithio intermediate with electrophiles provides access to a variety of 7-substituted derivatives.
• Synthesis of a Novel Oxazolo[4,5-<i>f</i>][1,6]naphthyridine
  作者：Ronald K. Russell、O. William Lever

  DOI：10.1080/00397919308012615

  日期：1993.11

  7-Azo-2-diethylaminooxazolo-[4,5-b]pyridine (1) is converted in 5 steps to the novel oxazolo[4,5-f][1,6]naphthyridine-6-oxo-7-carboxylic acid 6.