2-(1-(p-tolyl)ethyl)naphthalene | 78604-62-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2-(1-(p-tolyl)ethyl)naphthalene
• 英文别名: 2-[1-(4-Methylphenyl)ethyl]naphthalene
• CAS: 78604-62-3
• 化学式: C₁₉H₁₈
• 分子量: 246.352
• InChiKey: UKXMHRKIIVOCOA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为产物：
  描述：

  2,3-dihydro-3-(4'-methylphenyl)naphtho<1,2-b>thiophene 在 镍 作用下， 以 乙醇 为溶剂， 反应 18.0h， 生成 2-(1-(p-tolyl)ethyl)naphthalene
  参考文献：
  名称：

  Clark, Peter David; McKinnon, David M., Canadian Journal of Chemistry, 1981, vol. 59, p. 1297 - 1302

  摘要：

  DOI：

文献信息

• Palladium-catalyzed regioselective hydroboration of aryl alkenes with B₂pin₂
  作者：Jiuzhong Huang、Wuxin Yan、Chaowei Tan、Wanqing Wu、Huanfeng Jiang

  DOI：10.1039/c7cc09432a

  日期：——

  A palladium(II)-catalyzed hydroboration of aryl alkenes with stable and easy-to-handle (pinacolato)diboron (B2pin2) under mild conditions has been developed. Acetic acid acted as the solvent and the hydrogen source, which has been identified by deuterium experiments. Notably, isomerization–hydroboration of allyl benzene derivatives was observed. As a result, a series of benzyl boronic esters were obtained

  在温和的条件下，已开发出钯（II）催化的具有稳定且易于处理的（频哪醇）二硼烷（B 2 pin 2）的芳基烯烃加氢硼化反应。乙酸充当了溶剂和氢源，这已通过氘实验确定。值得注意的是，观察到烯丙基苯衍生物的异构化-硼氢化。结果，以中等至优异的产率获得了一系列苄基硼酸酯，并且具有唯一的区域选择性。
• Superacid BF₃–H₂O promoted benzylation of arenes with benzyl alcohols and acetates initiated by trace water
  作者：Shuting Zhang、Xiaohui Zhang、Xuege Ling、Chao He、Ruofeng Huang、Jing Pan、Jiaqiang Li、Yan Xiong

  DOI：10.1039/c4ra04059g

  日期：——

  An efficient in situ prepared superacid BF₃–H₂O promoted benzylation of arenes using benzyl alcohols and acetates achieves various diarylalkanes.

  一种高效的原位制备的超强酸BF3-H2O促进的芳烃苄基化反应，使用苄醇和醋酸酯制备各种二芳基烷烃。
• Iron-catalysed enantioconvergent Suzuki–Miyaura cross-coupling to afford enantioenriched 1,1-diarylalkanes
  作者：Chet C. Tyrol、Nang S. Yone、Connor F. Gallin、Jeffery A. Byers

  DOI：10.1039/d0cc05003b

  日期：——

  The first stereoconvergent Suzuki–Miyaura cross-coupling reaction was developed to afford enantioenriched 1,1-diarylalkanes.

  第一个立体对映选择性的铃木-宫浦偶联反应被开发出来，用于合成手性富集的1,1-二芳基烷烃。
• One-pot reductive coupling reactions of acetyl naphthalene derivatives, tosylhydrazide, with arylboronic acids
  作者：Xu Shen、Ping Liu、Yang Liu、Yan Liu、Bin Dai

  DOI：10.1016/j.tet.2016.12.068

  日期：2017.2

  one-pot two-step reductive coupling between acetyl naphthalene derivatives, tosylhydrazide, and arylboronic acids, affording substituted 1(or 2)-(1-phenylethyl)naphthalenes in moderate-to-excellent yields, was reported. Notably, solvent played a crucial role in the coupling of 1-acetyl naphthalene derivatives (toluene) or 2-acetyl naphthalene derivatives (1,4-dioxane) as starting materials. Meanwhile,

  在这项研究中，报告了乙酰萘衍生物，甲苯磺酰肼和芳基硼酸之间的一锅两步还原偶联，以中等至优异的产率提供了取代的1（或2）-（1-苯乙基）萘。值得注意的是，溶剂在作为起始原料的1-乙酰基萘衍生物（甲苯）或2-乙酰基萘衍生物（1,4-二恶烷）的偶联中起关键作用。同时，该一锅偶联反应的范围扩展到了1（或2）-萘醛底物。特别地，该系统也适合于以克数级合成1（或2）-（1-苯乙基）萘，并且被用于合成萘甲基甲基取代的咔唑基化合物。
• Practical Cross-Coupling between O-Based Electrophiles and Aryl Bromides via Ni Catalysis
  作者：Zhi-Chao Cao、Qin-Yu Luo、Zhang-Jie Shi

  DOI：10.1021/acs.orglett.6b02656

  日期：2016.12.2

  Cross-coupling of various O-based electrophiles with aryl bromides was developed through Ni-catalyzed C–O activation in the presence of magnesium. Beside carboxylates, carbamates, and ethers, phenols exhibited excellent reactivity under modified conditions. This chemistry was featured as a simple and environmentally benign process with low catalyst loading and easy manipulations. The method exhibited

  在镁的存在下，通过Ni催化的C–O活化，开发出了各种基于O的亲电试剂与芳基溴化物的交叉偶联反应。除羧酸盐，氨基甲酸酯和醚外，酚在改性条件下还具有出色的反应活性。该化学反应具有催化剂用量低，易于操作的简单，环保的特点。该方法展示了广泛的底物范围。