N-((3R,5S)-1-(benzofuran-3-carbonyl)-5-formylpyrrolidin-3-yl)-3-ethyl-1-methyl-1Hpyrazole-5-carboxamide | 1558041-24-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并呋喃
• 英文名称: N-((3R,5S)-1-(benzofuran-3-carbonyl)-5-formylpyrrolidin-3-yl)-3-ethyl-1-methyl-1Hpyrazole-5-carboxamide
• CAS: 1558041-24-9
• 化学式: C₂₁H₂₂N₄O₄
• 分子量: 394.43
• InChiKey: ZUPZNTUGYZXUFZ-CABCVRRESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.94
• 重原子数：
  29.0
• 可旋转键数：
  5.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  97.44
• 氢给体数：
  1.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  N-((3R,5S)-1-(benzofuran-3-carbonyl)-5-formylpyrrolidin-3-yl)-3-ethyl-1-methyl-1Hpyrazole-5-carboxamide 、 甘氨酸甲酯盐酸盐 在 三乙酰氧基硼氢化钠 、 三乙胺 作用下， 以30%的产率得到methyl 2-((((2S,4R)-1-(benzofuran-3-carbonyl)-4-(3-ethyl-1-methyl-1H-pyrazole-5-carboxamido)pyrrolidin-2-yl)methyl)amino)acetate
  参考文献：
  名称：

  Encoded Library Technology as a Source of Hits for the Discovery and Lead Optimization of a Potent and Selective Class of Bactericidal Direct Inhibitors of Mycobacterium tuberculosis InhA

  摘要：

  Tuberculosis (TB) is one of the world's oldest and deadliest diseases, killing a person every 20 s. InhA, the enoyl-ACP reductase from Mycobacterium tuberculosis, is the target of the frontline antitubercular drug isoniazid (INH). Compounds that directly target InhA and do not require activation by mycobacterial catalase peroxidase KatG are promising candidates for treating infections caused by INH resistant strains. The application of the encoded library technology (ELT) to the discovery of direct InhA inhibitors yielded compound 7 endowed with good enzymatic potency but with low antitubercular potency. This work reports the hit identification, the selected strategy for potency optimization, the structure-activity relationships of a hundred analogues synthesized, and the results of the in vivo efficacy studies performed with the lead compound 65.

  DOI：

  10.1021/jm401326j
• 作为产物：
  描述：

  5-乙基-2-甲基-2H-吡唑-3-甲酸 在 lithium aluminium tetrahydride 、 碳酸氢钠 、 戴斯-马丁氧化剂 、 N,N-二异丙基乙胺 、 三氟乙酸 、 N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate 作用下， 以 乙醚 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 8.0h， 生成 N-((3R,5S)-1-(benzofuran-3-carbonyl)-5-formylpyrrolidin-3-yl)-3-ethyl-1-methyl-1Hpyrazole-5-carboxamide
  参考文献：
  名称：

  Encoded Library Technology as a Source of Hits for the Discovery and Lead Optimization of a Potent and Selective Class of Bactericidal Direct Inhibitors of Mycobacterium tuberculosis InhA

  摘要：

  Tuberculosis (TB) is one of the world's oldest and deadliest diseases, killing a person every 20 s. InhA, the enoyl-ACP reductase from Mycobacterium tuberculosis, is the target of the frontline antitubercular drug isoniazid (INH). Compounds that directly target InhA and do not require activation by mycobacterial catalase peroxidase KatG are promising candidates for treating infections caused by INH resistant strains. The application of the encoded library technology (ELT) to the discovery of direct InhA inhibitors yielded compound 7 endowed with good enzymatic potency but with low antitubercular potency. This work reports the hit identification, the selected strategy for potency optimization, the structure-activity relationships of a hundred analogues synthesized, and the results of the in vivo efficacy studies performed with the lead compound 65.

  DOI：

  10.1021/jm401326j