8-methoxy-4-methyl-2-phenyl-benz[e]isoindole-1,3-dione | 102024-31-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 8-methoxy-4-methyl-2-phenyl-benz[e]isoindole-1,3-dione
• 英文别名: 8-methoxy-4-methyl-2-phenyl-benz[e]isoindole-1,3-dione；8-Methoxy-4-methyl-2-phenyl-benz[e]isoindol-1,3-dion
• CAS: 102024-31-7
• 化学式: C₂₀H₁₅NO₃
• 分子量: 317.344
• InChiKey: USRXHACYMIWSSN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.96
• 重原子数：
  24.0
• 可旋转键数：
  2.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  46.61
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为产物：
  描述：

  7-methoxy-3-methyl-naphthalene-1,2-dicarboxylic acid-anhydride 、 苯胺 生成 8-methoxy-4-methyl-2-phenyl-benz[e]isoindole-1,3-dione
  参考文献：
  名称：

  Progressive ataxia and seizures in a Cocker Spaniel: a new type of neurodegenerative disease with novel intra-neuronal inclusions

  摘要：

  AIMS: To describe the histopathological lesions of a new canine disease characterised by progressive ataxia, head tremor and seizures, and to deduce the cause of the lesions.METHODS: Formalin-fixed tissues were processed into paraffin wax and epoxy resin for light and transmission electron microscopy of variously stained tissue sections.RESULTS: Significant lesions relevant to the disease were found only in the brain. They consisted of hypoplasia of the cerebellum and the presence of large pale inclusions in the perikaryon of neurons in the neocortex and in macrophages. The inclusion material was not compartmentalised and did not stain for carbohydrate, mucopolysaccharide or lipid. This material displaced nuclei to the periphery of the cells where they were seen as basophilic distorted crescent-shaped structures.CONCLUSIONS: The inclusions were probably made of polymerised protein similar, though not identical, to those of Pick, Lewy and Collins bodies that characterise a variety of chronic neurodegenerative diseases of humans. A genetic basis to this disease was considered probable.

  DOI：

  10.1080/00480169.2002.36312