meso-3,4-bis-(4-hydroxy-phenyl)-hexane-3,4-diol | 18978-24-0

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: meso-3,4-bis-(4-hydroxy-phenyl)-hexane-3,4-diol
• 英文别名: meso-3,4-Bis-(4-hydroxy-phenyl)-hexan-3,4-diol；meso-3.4-Bis-(4-hydroxy-phenyl)-hexandiol-(3.4)；(3R,4S)-3,4-bis(4-hydroxyphenyl)hexane-3,4-diol
• CAS: 18978-24-0
• 化学式: C₁₈H₂₂O₄
• 分子量: 302.37
• InChiKey: MOGCNGHSEICQCE-HDICACEKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  80.9
• 氢给体数：
  4
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  meso-3,4-bis-(4-hydroxy-phenyl)-hexane-3,4-diol 生成 meso-3.4-bis-[4-(toluene-sulfonyl-(4)-oxy)-phenyl]-hexanediol-(3,4)
  参考文献：
  名称：

  Effect of Low-Fat and/or Low-Energy Diets on Anthropometric Measures in Participants of the Women’s Diet Study

  摘要：

  Objective: To compare the effects of low-fat, low-energy and combination low-fat/low-energy intervention on changes in six anthropometric measures in Caucasian and African-American free-living women.Methods: The effects of dietary counseling strategies for fat and/or energy reduction were examined on anthropometric measures in 86 pre-menopausal women, average BMI of 28 kg/m(2), who participated in a 12-week intervention trial called the Women's Diet Study. The dietary goals were 1510 of energy from fat and/or 25% reduction in energy intake, relative to reported baseline intake, using a 2 x 2 factorial design. Analysis of covariance models were constructed to evaluate changes in anthropometric measures over the 12 weeks of study.Results: The biggest difference by race was in women who were relatively heavier at baseline, in which case African-American women lost significantly less weight but decreased their waist:hip ratio to a significantly greater extent than Caucasian women. With regard to the effects of diet arm, weight loss varied depending on baseline weight, and in women with higher baseline weights, the combination low-fat/low-energy diet resulted in the most weight loss (6.7 kg, p < 0.05). Decreases in the other anthropometric measures at week 12 were more uniform across diet arms and did not depend on baseline values. After controlling for previous weight history and race, the decreases in BMI, percent body fat and waist circumference after 12 weeks were statistically equivalent with the low-fat, low-energy or combination low-fat/low-energy diets. The relatively greater decreases in percent body fat and waist circumference with the combination diet versus the low-fat or low-energy diets were not statistically significant.Conclusion: The low-fat, low-energy and combination diets all resulted in similar and statistically significant decreases in BMI, percent body fat and waist circumference over 12 weeks of intervention. The extent of weight loss, however, varied depending on baseline weight, and the combination diet was the only intervention to result in significant weight loss for women who were heavier at baseline. This indicates that, although there may be an advantage for reducing dietary fat in initially heavier women, any of these counseling strategies could be effective for improving anthropometric predictors of health risks associated with overweight status. This is useful since flexibility in dietary choices may facilitate adherence to dietary counseling in some individuals.

  DOI：

  10.1080/07315724.2002.10719192
• 作为产物：
  描述：

  meso-3.4-Bis-(4-acetoxy-phenyl)-hexandiol-(3.4) 在 氢氧化钾 作用下， 生成 meso-3,4-bis-(4-hydroxy-phenyl)-hexane-3,4-diol
  参考文献：
  名称：

  Adler; Lundin, Arkiv foer Kemi, 1945, vol. 19 A, # 24, p. 3,7

  摘要：

  DOI：

文献信息

• Dodds et al., Proceedings of the Royal Society of London. Series B, Biological sciences, 1939, vol. 127, p. 140,153 Anm. 154
  作者：Dodds et al.

  DOI：——

  日期：——
• v. Wessely et al., Monatshefte fur Chemie, 1941, vol. 73, p. 127,158
  作者：v. Wessely et al.

  DOI：——

  日期：——
• Substituted ethylene oxide compounds and process for preparing the same
  申请人：PARKE DAVIS & CO

  公开号：US02393129A1

  公开（公告）日：1946-01-15
• Process for the production of tetrasubstituted ethylenes
  申请人：PARKE DAVIS & CO

  公开号：US02349770A1

  公开（公告）日：1944-05-23
• CH245066
  申请人：——

  公开号：——

  公开（公告）日：——