1-(3-Trifluoromethyl-phenyl)-piperidine-4-carboxylic acid (1-acetyl-2,3-dihydro-1H-indol-6-yl)-amide | 888036-78-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 1-(3-Trifluoromethyl-phenyl)-piperidine-4-carboxylic acid (1-acetyl-2,3-dihydro-1H-indol-6-yl)-amide
• 英文别名: N-(1-acetylindolin-6-yl)-1-(3-(trifluoromethyl)phenyl)piperidine-4-carboxamide；N-(1-acetyl-2,3-dihydroindol-6-yl)-1-[3-(trifluoromethyl)phenyl]piperidine-4-carboxamide
• CAS: 888036-78-0
• 化学式: C₂₃H₂₄F₃N₃O₂
• 分子量: 431.458
• InChiKey: KGQAPJAQDIKPLK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  31
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  52.6
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  1-[3-(trifluoromethyl)phenyl]piperidine-4-carboxylic acid 、 1-乙酰基-6-氨基吲哚 生成 1-(3-Trifluoromethyl-phenyl)-piperidine-4-carboxylic acid (1-acetyl-2,3-dihydro-1H-indol-6-yl)-amide
  参考文献：
  名称：

  4-Piperidinecarboxamide modulators of vanilloid VR1 receptor

  摘要：

  本发明涉及辣椒素受体VR1配体。更具体地说，本发明涉及异构异壳素酰胺，它们是VR1的有效调节剂，可用于哺乳动物的疾病治疗和预防。

  公开号：

  US20060116368A1

文献信息

• 4-Piperidinecarboxamide modulators of vanilloid VR1 receptor
  申请人：Calvo R. Raul

  公开号：US20060116368A1

  公开（公告）日：2006-06-01

  This invention is directed to vanilloid receptor VR1 ligands. More particularly, this invention relates to hetero isonipecotic amides that are potent modulators of VR1 which are useful for the treatment and prevention of disease conditions in mammals.

  本发明涉及辣椒素受体VR1配体。更具体地说，本发明涉及异构异壳素酰胺，它们是VR1的有效调节剂，可用于哺乳动物的疾病治疗和预防。
• Discovery of piperidine carboxamide TRPV1 antagonists
  作者：Wing S. Cheung、Raul R. Calvo、Brett A. Tounge、Sui-Po Zhang、Dennis R. Stone、Michael R. Brandt、Tasha Hutchinson、Christopher M. Flores、Mark R. Player

  DOI：10.1016/j.bmcl.2008.07.035

  日期：2008.8

  A series of piperidine carboxamides were developed as potent antagonists of the transient receptor potential vanilloid-1 (TRPV1), an emerging target for the treatment of pain. A focused library of polar head groups led to the identification of a benzoxazinone amide that afforded good potency in cell-based assays. Synthesis and a QSAR model will be presented. (C) 2008 Elsevier Ltd. All rights reserved.