1-Formamido-2-naphthol | 52260-19-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1-Formamido-2-naphthol
• 英文别名: N-(2-hydroxy-[1]naphthyl)-formamide；N-(2-Hydroxy-[1]naphthyl)-formamid；1-Formamino-naphthol-(2)；N-(2-hydroxynaphthalen-1-yl)formamide
• CAS: 52260-19-2
• 化学式: C₁₁H₉NO₂
• 分子量: 187.198
• InChiKey: QKSMWTRRSUEXPC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-Formamido-2-naphthol 在 碘苯二乙酸 作用下， 以 叔丁醇 为溶剂， 以80%的产率得到naphtho[1,8-de][1,2]oxazine
  参考文献：
  名称：

  Novel Thermal and Microwave-Assisted Facile Route to Naphthalen-2(1H)-ones via an Oxidative Alkoxylation-Ring-Opening Protocol

  摘要：

  Several novel 1,1-disubstituted-8-hydroxynaphthalen-2(1H)-ones have been efficiently synthesized via a two-step sequence from 2-hydroxy-1-naphthaldehyde oxime. The methodology involves oxidative ring closure and alkoxylation to 3a-alkoxynaphtho[1,8-de][1,2]oxazin-4(3aH)-ones, followed by thermal ring-opening. Both thermal and microwave irradiation conditions were used. A novel one-pot reaction of oxime to 8-isopropoxynaphthalene-1,7-diol using microwave irradiation is also reported.

  DOI：

  10.1021/ol9008574
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 水 作用下， 生成 1-Formamido-2-naphthol
  参考文献：
  名称：

  Fischer,O.; Roemer, Journal fur praktische Chemie (Leipzig 1954), 1906, vol. <2>73, p. 442ff.

  摘要：

  DOI：

文献信息

• Fischer,O.; Roemer, Journal fur praktische Chemie (Leipzig 1954), 1906, vol. <2>73, p. 442ff.
  作者：Fischer,O.、Roemer

  DOI：——

  日期：——
• Novel Thermal and Microwave-Assisted Facile Route to Naphthalen-2(1<i>H</i>)-ones via an Oxidative Alkoxylation-Ring-Opening Protocol
  作者：Chrysanthi Dolka、Kristof Van Hecke、Luc Van Meervelt、Petros G. Tsoungas、Erik V. Van der Eycken、George Varvounis

  DOI：10.1021/ol9008574

  日期：2009.7.16

  Several novel 1,1-disubstituted-8-hydroxynaphthalen-2(1H)-ones have been efficiently synthesized via a two-step sequence from 2-hydroxy-1-naphthaldehyde oxime. The methodology involves oxidative ring closure and alkoxylation to 3a-alkoxynaphtho[1,8-de][1,2]oxazin-4(3aH)-ones, followed by thermal ring-opening. Both thermal and microwave irradiation conditions were used. A novel one-pot reaction of oxime to 8-isopropoxynaphthalene-1,7-diol using microwave irradiation is also reported.