{(1R,2S,5S)-3-[(2-methyl-5-phenyl-1,3-thiazol-4-yl)carbonyl]-3-azabicyclo[3.1.0]hex-2-yl}methanol | 1092506-55-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: {(1R,2S,5S)-3-[(2-methyl-5-phenyl-1,3-thiazol-4-yl)carbonyl]-3-azabicyclo[3.1.0]hex-2-yl}methanol
• 英文别名: [(1R,2S,5S)-2-(hydroxymethyl)-3-azabicyclo[3.1.0]hexan-3-yl]-(2-methyl-5-phenyl-1,3-thiazol-4-yl)methanone
• CAS: 1092506-55-2
• 化学式: C₁₇H₁₈N₂O₂S
• 分子量: 314.408
• InChiKey: OTXTUZROICHMHL-MGPQQGTHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  81.7
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  {(1R,2S,5S)-3-[(2-methyl-5-phenyl-1,3-thiazol-4-yl)carbonyl]-3-azabicyclo[3.1.0]hex-2-yl}methanol 在 三乙胺 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 18.5h， 生成 2-[({(1R,2S,5S)-3-[(2-methyl-5-phenyl-1,3-thiazol-4-yl)carbonyl]-3-azabicyclo[3.1.0]hex-2-yl}methyl)thio]-1H-benzimidazole
  参考文献：
  名称：

  WO2008/150364

  摘要：

  公开号：

文献信息

• CYCLOPROPYL PYRROLIDINE OREXIN RECEPTOR ANTAGONISTS
  申请人：Coleman Paul J.

  公开号：US20100152191A1

  公开（公告）日：2010-06-17

  The present invention is directed to cyclopropyl proline bis-amide compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved.

  本发明涉及环丙基脯氨酸双酰胺化合物，其为促进睡眠荷尔蒙受体的拮抗剂，并可用于治疗或预防神经和精神障碍以及涉及促进睡眠荷尔蒙受体的疾病。本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及促进睡眠荷尔蒙受体的疾病中的使用。
• Cyclopropyl pyrrolidine orexin receptor antagonists
  申请人：——

  公开号：US08030495B2

  公开（公告）日：2011-10-04

  The present invention is directed to cyclopropyl proline bis-amide compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved.

  本发明涉及环丙基脯氨酸双酰胺化合物，它们是促进睡眠荷尔蒙受体的拮抗剂，可用于治疗或预防涉及睡眠荷尔蒙受体的神经和精神障碍和疾病。本发明还涉及包含这些化合物的制药组合物以及在预防或治疗涉及睡眠荷尔蒙受体的疾病中使用这些化合物和组合物。
• US8030495B2
  申请人：——

  公开号：US8030495B2

  公开（公告）日：2011-10-04
• [EN] CYCLOPROPYL PYRROLIDINE OREXIN RECEPTOR ANTAGONISTS<br/>[FR] ANTAGONISTES DU RÉCEPTEUR DE LA CYCLOPROPYLPYRROLIDINE OREXINE
  申请人：MERCK & CO INC

  公开号：WO2008150364A1

  公开（公告）日：2008-12-11

  [EN] The present invention is directed to cyclopropyl proline bis-amide compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved.
  [FR] La présente invention concerne des composés de cyclopropylproline bis-amide qui sont des antagonistes des récepteurs de l'orexine et se révèlent utiles pour le traitement ou la prévention de troubles neurologiques et psychiatriques ainsi que de maladies impliquant les récepteurs de l'orexine. L'invention concerne également des compositions pharmaceutiques contenant lesdits composés et l'utilisation de ces composés et compositions pour la prévention ou le traitement desdites maladies impliquant les récepteurs de l'orexine.