(3aR,5R,6R,6aR)-6-(1-benzofuran-2-ylmethyl)-5-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]-2,2-dimethyl-5,6a-dihydro-3aH-furo[2,3-d][1,3]dioxol-6-ol | 1426660-13-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并呋喃
• 英文名称: (3aR,5R,6R,6aR)-6-(1-benzofuran-2-ylmethyl)-5-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]-2,2-dimethyl-5,6a-dihydro-3aH-furo[2,3-d][1,3]dioxol-6-ol
• CAS: 1426660-13-0
• 化学式: C₂₁H₂₆O₇
• 分子量: 390.433
• InChiKey: GPYUJSOESBZFBK-ZIKOTGLESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  28
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  79.5
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  (3aR,5R,6R,6aR)-5-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-6-prop-2-ynyl-tetrahydro-furo[2,3-d][1,3]dioxol-6-ol 、 2-碘苯酚 在 bis-triphenylphosphine-palladium(II) chloride 、 copper(l) iodide 、 三乙胺 、 三苯基膦 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 6.0h， 以86%的产率得到(3aR,5R,6R,6aR)-6-(1-benzofuran-2-ylmethyl)-5-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]-2,2-dimethyl-5,6a-dihydro-3aH-furo[2,3-d][1,3]dioxol-6-ol
  参考文献：
  名称：

  Target cum flexibility: simple access to benzofuran conjugated sugar and nucleoside derivatives

  摘要：

  The [Pd]-catalyzed domino process comprising of the coupling of alkynes and o-iodophenol and the subsequent cyclization leading to benzofurans has been successfully applied on the sugar and nucleoside derived alkynes. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2013.01.089

文献信息

• Target cum flexibility: simple access to benzofuran conjugated sugar and nucleoside derivatives
  作者：Yadagiri Kommagalla、Kolluru Srinivas、C.V. Ramana

  DOI：10.1016/j.tetlet.2013.01.089

  日期：2013.4

  The [Pd]-catalyzed domino process comprising of the coupling of alkynes and o-iodophenol and the subsequent cyclization leading to benzofurans has been successfully applied on the sugar and nucleoside derived alkynes. (C) 2013 Elsevier Ltd. All rights reserved.