2-N-biotinyl-3-((2,3-bis(octadecyloxy)propyl)disulfanyl)-2-aminopropanol | 1278996-74-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 生物素及其衍生物
• 英文名称: 2-N-biotinyl-3-((2,3-bis(octadecyloxy)propyl)disulfanyl)-2-aminopropanol
• CAS: 1278996-74-9
• 化学式: C₅₂H₁₀₁N₃O₅S₃
• 分子量: 944.589
• InChiKey: XXLKXKIRNHWINT-XDYSCEPQSA-N

物化性质

• 熔点：
  112-114 °C
• 沸点：
  978.1±65.0 °C(Predicted)
• 密度：
  1.008±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  14.5
• 重原子数：
  63.0
• 可旋转键数：
  49.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.96
• 拓扑面积：
  108.92
• 氢给体数：
  4.0
• 氢受体数：
  8.0

反应信息

• 作为反应物：
  描述：

  2-dansylamino-N-(2-succinyloxyethyl)-N,N-dimethylethanammonium bromide 、 2-N-biotinyl-3-((2,3-bis(octadecyloxy)propyl)disulfanyl)-2-aminopropanol 在 4-二甲氨基吡啶 、 N,N'-二环己基碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 40.0 ℃ 、200.0 kPa 条件下， 反应 336.0h， 以55%的产率得到2-[4-[2-[5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoylamino]-3-(2,3-dioctadecoxypropyldisulfanyl)propoxy]-4-oxobutanoyl]oxyethyl-[2-[[5-(dimethylamino)naphthalen-1-yl]sulfonylamino]ethyl]-dimethylazanium
  参考文献：
  名称：

  Synthesis of novel amphiphilic conjugates with a biological recognition function for developing targeted triggered liposomal delivery systems

  摘要：

  Several novel amphiphilic lipid derivatives were synthesized consisting of a lipid anchor connected to the hydrophilic moiety via a disulfide or glycoside bond and biotin linked to the hydrophilic part. Disulfide bonds were established by the help of 4-phenyltriazol-3,5-dione. Dansyl or fluorescein was covalently linked as fluorescent marker to some of the conjugates, allowing spectroscopic and microscopic detection. The conjugates represent first amphiphilic lipids carrying all four functions, i.e., lipophilic, hydrophilic, recognition, and disulfide cleavage group in one molecule, which are necessary for targeted, triggered drug delivery from phospholipid liposomes on demand. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2011.07.089
• 作为产物：
  描述：

  1-(benzylthio)-3-(tert-butyldiphenylsilyloxy)propan-2-biotinylamide 在 PTAD 、 氟化铵 、 四丁基氟化铵 、 氨 、 sodium 作用下， 以 四氢呋喃 、 二氯甲烷 、 乙腈 为溶剂， 反应 100.0h， 生成 2-N-biotinyl-3-((2,3-bis(octadecyloxy)propyl)disulfanyl)-2-aminopropanol
  参考文献：
  名称：

  Synthesis of novel amphiphilic conjugates with a biological recognition function for developing targeted triggered liposomal delivery systems

  摘要：

  Several novel amphiphilic lipid derivatives were synthesized consisting of a lipid anchor connected to the hydrophilic moiety via a disulfide or glycoside bond and biotin linked to the hydrophilic part. Disulfide bonds were established by the help of 4-phenyltriazol-3,5-dione. Dansyl or fluorescein was covalently linked as fluorescent marker to some of the conjugates, allowing spectroscopic and microscopic detection. The conjugates represent first amphiphilic lipids carrying all four functions, i.e., lipophilic, hydrophilic, recognition, and disulfide cleavage group in one molecule, which are necessary for targeted, triggered drug delivery from phospholipid liposomes on demand. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2011.07.089