2-n-butoxyethoxycarbonyl chloride | 41905-52-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机碳酸及其衍生物
• 英文名称: 2-n-butoxyethoxycarbonyl chloride
• 英文别名: 2-butoxyethyl chloroformate；chlorocarbonic acid-(2-butoxy-ethyl ester)；Chlorameisensaeure-(2-butyloxy-aethylester)；Chlorokohlensaeure-(2-butoxy-aethylester)；chloro-formic acid 2-butoxy-ethyl ester；2-Butoxyethyl carbonochloridate
• CAS: 41905-52-6
• 化学式: C₇H₁₃ClO₃
• 分子量: 180.631
• InChiKey: MNKKXTGFPVEFRY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  11
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

安全信息

• 海关编码：
  2915900090

反应信息

• 作为反应物：
  描述：

  2-n-butoxyethoxycarbonyl chloride 在 氨 、 水 作用下， 生成 carbamic acid-(2-butoxy-ethyl ester)
  参考文献：
  名称：

  β-Alkoxy Ethyl Esters of Chlorocarbonic and Carbamic Acids

  摘要：

  DOI：

  10.1021/ja01279a029
• 作为产物：
  描述：

  光气 、 乙二醇单丁醚 以 甲苯 为溶剂， 生成 2-n-butoxyethoxycarbonyl chloride
  参考文献：
  名称：

  Fluorogenic or fluorescent reporter molecules and their applications for whole-cell fluorescence screening assays for caspases and other enzymes and the use thereof

  摘要：

  本发明涉及新型荧光染料、新型荧光报告分子和新的酶测定过程，可用于检测整个细胞、细胞系和来源于任何生物或器官的组织样本中参与凋亡的caspase和其他酶的活性。报告分子和测定过程可用于药物筛选程序，以确定在整个细胞或组织中作为caspase级联抑制剂或诱导剂的化合物。本文所述的试剂和测定也可用于确定人类癌细胞对化疗药物治疗的化学敏感性。本发明还涉及新型荧光报告分子和新的酶测定过程，可用于检测2型甲硫氨酰肽酶、二肽基肽酶IV、钙蛋白酶、氨肽酶、HIV蛋白酶、腺病毒蛋白酶、HSV-1蛋白酶、HCMV蛋白酶和HCV蛋白酶的活性。

  公开号：

  US06335429B1

文献信息

• ASYMMETRIC ORGANIC PEROXIDE, CROSSLINKING AGENT COMPRISING THE SAME, AND METHOD OF CROSSLINKING WITH THE SAME
  申请人：NOF CORPORATION

  公开号：EP1233014A1

  公开（公告）日：2002-08-21

  A crosslinking agent comprising an asymmetry organic peroxide having at least one structure unit of (substituted)benzoylcarbonyloxy group represented by the following formula (1) in the molecule thereof. Environmentally friendly crosslinking agents and crosslinked silicone rubber moldings are provided thereby. Specifically, useful crosslinking agents and crosslinking processes for silicone rubber are provided.

  一种交联剂，包括至少具有分子中表示为以下式（1）的（取代）苯甲酰羰氧基结构单元的不对称有机过氧化物。因此提供了环保的交联剂和交联硅橡胶成型品。具体提供了用于硅橡胶的有用交联剂和交联工艺。
• Novel fluorogenic or fluorescent reporter molecules and their applications for whole-cell fluorescence screening assays for caspases and other enzymes and the use thereof
  申请人：Cytovia, Inc.

  公开号：US20020150885A1

  公开（公告）日：2002-10-17

  The present invention relates to novel fluorescent dyes, novel fluorogenic and fluorescent reporter molecules and new enzyme assay processes that can be used to detect the activity of caspases and other enzymes involved in apoptosis in whole cells, cell lines and tissue samples derived from any living organism or organ. The reporter molecules and assay processes can be used in drug screening procedures to identify compounds which act as inhibitors or inducers of the caspase cascade in whole cells or tissues. The reagents and assays described herein are also useful for determining the chemosensitivity of human cancer cells to treatment with chemotherapeutic drugs. The present invention also relates to novel fluorogenic and fluorescent reporter molecules and new enzyme assay processes that can be used to detect the activity of type 2 methionine aminopeptidase, dipeptidyl peptidase IV, calpain, aminopeptidase, HIV protease, adenovirus protease, HSV-1 protease, HCMV protease and HCV protease.

  本发明涉及新型荧光染料、新型荧光报告分子和新的酶测定方法，可以用于检测整个细胞、细胞系和来自任何生物体或器官的组织样本中参与凋亡的caspase和其他酶的活性。报告分子和测定方法可用于药物筛选程序，以识别在整个细胞或组织中作为caspase级联抑制剂或诱导剂的化合物。本文介绍的试剂和测定也可用于确定人类癌细胞对化疗药物治疗的化学敏感性。本发明还涉及新型荧光报告分子和新的酶测定方法，可用于检测第2型甲硫氨酸肽酶、二肽基肽酶IV、钙蛋白酶、氨肽酶、HIV蛋白酶、腺病毒蛋白酶、HSV-1蛋白酶、HCMV蛋白酶和HCV蛋白酶的活性。
• Process for preparing 2-carbamoyloxyalkyl-1,4-dihydropyridine derivatives and intermediates useful for the process
  申请人：BANYU PHARMACEUTICAL CO., LTD.

  公开号：EP0101023A1

  公开（公告）日：1984-02-22

  A process for preparing a 2-carbamoyloxyalkyl-1,4-dihydropyridine derivative represented by the general formula: which comprises: (a) reacting a 3-amino-3-carbamoyloxyalkylacrylic acid derivative represented by the general formula: with a benzylidene compound represented by the general formula: (b) reacting the 3-amino-3-carbamoyloxyalkylacrylic acid derivative of the general formula II with an aldehyde comoound reoresented bv the aeneral formula: and a β-keto-ester compound represented by the general formula: (c) reacting a 3-carbamoyloxyalkylpropiolic acid derivative represented by the general formula: with the benzylidene compound of the general formula III and ammonia or its salt: or (d) reacting the 3-carbamoyloxyalkylpropiolic acid derivative of the general formula VI with the aldehyde compound of the general formula IV, the β-keto-ester compound of the general formula V and ammonia or its salt, and the intermediates of formula II and VI.

  一种制备通式为 2-氨基甲酰氧基烷基-1,4-二氢吡啶衍生物的工艺： 其中包括 (a) 将通式为 3-氨基-3-氨基甲酰氧基烷基丙烯酸衍生物与通式为 与通式代表的亚苄基化合物反应： (b) 将通式 II 的 3-氨基-3-氨基甲酰氧基烷基丙烯酸衍生物与通式......代表的醛化合物和通式......代表的β-酮酯化合物反应： 和通式代表的 β-酮酯化合物反应： (c) 将通式代表的 3-氨基甲酰氧基烷基丙炔酸衍生物与通式代表的 β-酮酯化合物反应： 与通式 III 的亚苄基化合物和氨或其盐反应：或 (d) 将通式 VI 的 3-氨基甲酰氧基烷基丙炔酸衍生物与通式 IV 的醛化合物、通式 V 的 β-酮酯化合物和氨或其盐以及通式 II 和 VI 的中间产物反应。
• Novel hydroxy-peroxides and their uses
  申请人：ATOCHEM NORTH AMERICA, INC.

  公开号：EP0381135A2

  公开（公告）日：1990-08-08

  Novel hydroxy peroxides of the Structure A [wherein R-, -R11- and -X- are as defined in the Summary of the Invention Section], having 10 hour half-life temperatures of 85-100 °C, the processes for their preparation, and the use of these novel compositions in curing of unsaturated polyester resins and in initiating polymerization of ethylenically unsaturated monomers.

  结构 A 的新型羟基过氧化物 [其中 R-、-R11- 和 -X- 的定义见发明概述部分]、 其半衰期为 10 小时，温度为 85-100 °C，其制备工艺，以及这些新型组合物在固化不饱和聚酯树脂和引发乙烯基不饱和单体聚合中的用途。
• Novel oxalic acid peroxide compositions and uses
  申请人：ELF ATOCHEM NORTH AMERICA, INC.

  公开号：EP0850927A1

  公开（公告）日：1998-07-01

  A novel peroxide composition of Structure A, and use of the novel oxalic acid peroxide composition of Structure A as an initiator; a) for curing of unsaturated polyester resins, b) for polymerizing ethylenically unsaturated monomers, c) for crosslinking of polyolefins, d) for curing of elastomers, e) for modifying polyolefins, f) for grafting of vinyl monomers onto polymer backbones and g) for compatibilizing blends of two or more incompatible polymers are disclosed.

  结构 A 的新型过氧化物组合物 结构 A 的新型草酸过氧化物组合物作为引发剂；a) 用于不饱和聚酯树脂的固化；b) 用于乙烯基不饱和单体的聚合；c) 用于聚烯烃的交联；d) 用于弹性体的固化；e) 用于聚烯烃的改性；f) 用于乙烯基单体在聚合物骨架上的接枝；g) 用于两种或两种以上不相容聚合物混合物的相容。