5-(3,3-dimethyl-but-1-ynyl)3-(3-hydroxy-1-(S)-methyl-propylamino)thiophene-2-carboxyli cacid methyl ester | 1263099-50-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩类
• 英文名称: 5-(3,3-dimethyl-but-1-ynyl)3-(3-hydroxy-1-(S)-methyl-propylamino)thiophene-2-carboxyli cacid methyl ester
• 英文别名: 5-(3,3-dimethyl-but-1-ynyl)-3-(3-hydroxy-1-(S)-methyl-propylamino)-thiophene-2-carboxylic acid methyl ester；methyl 5-(3,3-dimethylbut-1-ynyl)-3-[[(2S)-4-hydroxybutan-2-yl]amino]thiophene-2-carboxylate
• CAS: 1263099-50-8
• 化学式: C₁₆H₂₃NO₃S
• 分子量: 309.43
• InChiKey: OZFRTWDHVRZTQT-NSHDSACASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  21
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  86.8
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  5-(3,3-dimethyl-but-1-ynyl)3-(3-hydroxy-1-(S)-methyl-propylamino)thiophene-2-carboxyli cacid methyl ester 在 吡啶 、 甲醇 、 lithium hydroxide monohydrate 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 19.0h， 生成 5-(3,3-dimethylbut-1-ynyl)-3-((1r,4S)-N-((S)-4-hydroxybutan-2-yl)-4-methylcyclohexanecarboxamido)thiophene-2-carboxylic acid
  参考文献：
  名称：

  Discovery of GS-9669, a Thumb Site II Non-Nucleoside Inhibitor of NS5B for the Treatment of Genotype 1 Chronic Hepatitis C Infection

  摘要：

  Investigation of thiophene-2-carboxylic acid HCV NS5B site II inhibitors, guided by measurement of cell culture medium binding, revealed the structure activity relationships for intrinsic cellular potency. The pharmacokinetic profile was enhanced through incorporation of heterocyclic ethers on the N-alkyl substituent. Hydroxyl groups were incorporated to modulate protein binding. Intrinsic potency was further improved through enantiospecific introduction of an olefin in the N-acyl motif, resulting in the discovery of the phase 2 clinical candidate GS-9669. The unexpected activity of this compound against the clinically relevant NS5B M423T mutant, relative to the wild type, was shown to arise from both the N-alkyl substituent and the N-acyl group.

  DOI：

  10.1021/jm401420j
• 作为产物：
  描述：

  methyl 5-(3,3-dimethylbut-1-ynyl)-3-iodothiophene-2-carboxylate 在 四丁基氟化铵 、 palladium diacetate 、 R-(+)-1,1'-联萘-2,2'-双二苯膦 作用下， 以 四氢呋喃 、 甲苯 为溶剂， 反应 16.5h， 生成 5-(3,3-dimethyl-but-1-ynyl)3-(3-hydroxy-1-(S)-methyl-propylamino)thiophene-2-carboxyli cacid methyl ester
  参考文献：
  名称：

  Discovery of GS-9669, a Thumb Site II Non-Nucleoside Inhibitor of NS5B for the Treatment of Genotype 1 Chronic Hepatitis C Infection

  摘要：

  Investigation of thiophene-2-carboxylic acid HCV NS5B site II inhibitors, guided by measurement of cell culture medium binding, revealed the structure activity relationships for intrinsic cellular potency. The pharmacokinetic profile was enhanced through incorporation of heterocyclic ethers on the N-alkyl substituent. Hydroxyl groups were incorporated to modulate protein binding. Intrinsic potency was further improved through enantiospecific introduction of an olefin in the N-acyl motif, resulting in the discovery of the phase 2 clinical candidate GS-9669. The unexpected activity of this compound against the clinically relevant NS5B M423T mutant, relative to the wild type, was shown to arise from both the N-alkyl substituent and the N-acyl group.

  DOI：

  10.1021/jm401420j

文献信息

• INHIBITORS OF FLAVIVIRIDAE VIRUSES
  申请人：Canales Eda

  公开号：US20110020278A1

  公开（公告）日：2011-01-27

  Provided are compounds of Formula I: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections, particularly hepatitis C infections.

  提供的是I式化合物： 及其药用可接受的盐和酯。所提供的化合物、组合物和方法对于治疗黄病毒科病毒感染，特别是丙型肝炎感染，是有用的。
• Inhibitors of flaviviridae viruses
  申请人：Canales Eda

  公开号：US08569302B2

  公开（公告）日：2013-10-29

  Provided are compounds of Formula I: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections, particularly hepatitis C infections.

  提供了式I的化合物及其药学上可接受的盐和酯。所提供的化合物、组合物和方法对治疗黄病毒科病毒感染，特别是丙型肝炎感染具有有用性。
• 5-ALKINYLTHIEN-2-YLCARBOXYLIC ACIDS AS INHIBITORS OF FLAVIVIRIDAE VIRUSES
  申请人：Gilead Sciences, Inc.

  公开号：EP2475657B1

  公开（公告）日：2013-06-12
• US8569302B2
  申请人：——

  公开号：US8569302B2

  公开（公告）日：2013-10-29