2-Thiophenecarboxamide, 3-ethoxy- | 139926-21-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩类
• 英文名称: 2-Thiophenecarboxamide, 3-ethoxy-
• 英文别名: 3-ethoxythiophene-2-carboxamide
• CAS: 139926-21-9
• 化学式: C₇H₉NO₂S
• 分子量: 171.22
• InChiKey: SZZQTGDGOYRCRV-UHFFFAOYSA-N

物化性质

• 沸点：
  314.4±27.0 °C(Predicted)
• 密度：
  1.239±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  80.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3-乙氧基噻吩-2-羧酸 在 氯化亚砜 、 氨 作用下， 以 乙醚 、 N,N-二甲基甲酰胺 、 苯 为溶剂， 反应 2.25h， 生成 2-Thiophenecarboxamide, 3-ethoxy-
  参考文献：
  名称：

  解热镇痛药乙酰胺噻吩类似物的合成及初步药理研究

  摘要：

  对镇痛和解热剂 Ethenzamide 的噻吩类似物 1b 和密切相关的化合物 1a 的初步药理学研究表明，Ethenzamide 和噻吩化合物在镇痛、解热、致溃疡、低温和镇静作用方面存在很大的相似性。然而，噻吩类化合物对小鼠的急性毒性明显高于乙酰胺。

  DOI：

  10.1002/ardp.19923250206

文献信息

• 3-SUBSTITUTED-2(ARYLALKYL)-1-AZABICYCLOALKANES AND METHODS OF USE THEREOF
  申请人：Targacept, Inc.

  公开号：EP1594869A2

  公开（公告）日：2005-11-16
• ３−置換−２（アリールアルキル）−１−アザビシクロアルカンおよびこれらの使用方法
  申请人：ターガセプト,インコーポレイテッド

  公开号：JP4828407B2

  公开（公告）日：2006-08-17
• [EN] 3-SUBSTITUTED-2(ARYLALKYL)-1-AZABICYCLOALKANES AND METHODS OF USE THEREOF<br/>[FR] 2(ARYLALKYL)-1-AZABICYCLOALCANES SUBSTITUES EN POSITION 3 ET LEURS PROCEDES D'UTILISATION
  申请人：TARGACEPT INC

  公开号：WO2004076449A2

  公开（公告）日：2004-09-10

  The present invention relates to 3-substituted-2-(arylalkyl)-1-azabicycloalkanes, methods of preparing the compounds and methods of treatment using the compounds. The azabicycloalkanes generally are azabicycloheptanes, azabicyclooctanes, or azabicyclononanes. The aryl group in the arylalkyl moiety is a 5- or 6-membered ring heteroaromatic, preferably 3-pyridinyl and 5-pyrimidinyl moieties, and the alkyl group is typically a C1-4 alkyl. The substituent at the 3-position of the 1-azabicycloalkane is a carbonyl group-containing moiety, such as an amide, carbamate, urea, thioamide, thiocarbamate, thiourea or similar functionality. The compounds exhibit activity at nicotinic acetylcholine receptors (nAChRs), particularly the a7 nAChR subtype, and are useful towards modulating neurotransmission and the release of ligands involved in neurotransmission. Methods for preventing or treating conditions and disorders, including central nervous system (CNS) disorders, which are characterized by an alteration in normal neurotransmission, are also disclosed. Also disclosed are methods for treating inflammation, autoimmune disorders, pain and excess neovascularization, such as that associated with tumor growth.
• Synthesis and Preliminary Pharmacological Study of Thiophene Analogues of the Antipyretic and Analgesic Agent Ethenzamide
  作者：V. Darias、L. Bravo、S. S. Abdallah、C. C. Sánchez Mateo、M. A. Expósito-orta、J. Lissavetsky、J. Manzanares

  DOI：10.1002/ardp.19923250206

  日期：——

  A preliminary pharmacological study of a thiophene analogue 1b of the analgesic and antipyretic agent Ethenzamide and of a closely related compound 1a showed that a great similarity exists among Ethenzamide and the thiophenic compounds for analgesic, antipyretic, ulcerogenic, hypothermic, and sedative effects. However, the acute toxicity in mice for the thiophenic compounds is notably higher than that

  对镇痛和解热剂 Ethenzamide 的噻吩类似物 1b 和密切相关的化合物 1a 的初步药理学研究表明，Ethenzamide 和噻吩化合物在镇痛、解热、致溃疡、低温和镇静作用方面存在很大的相似性。然而，噻吩类化合物对小鼠的急性毒性明显高于乙酰胺。