(2S,3S)-4-(bis(4-methoxyphenyl)(phenyl)methoxy)-3-(4-(phenyldiazenyl)benzamido)butan-2-yl (2-cyanoethyl) diisopropylphosphoramidite | 1227873-20-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: (2S,3S)-4-(bis(4-methoxyphenyl)(phenyl)methoxy)-3-(4-(phenyldiazenyl)benzamido)butan-2-yl (2-cyanoethyl) diisopropylphosphoramidite
• CAS: 1227873-20-2
• 化学式: C₄₇H₅₄N₅O₆P
• 分子量: 815.949
• InChiKey: HWVZOGDVVZLMFF-AKCAFWOHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.91
• 重原子数：
  59.0
• 可旋转键数：
  21.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  127.0
• 氢给体数：
  1.0
• 氢受体数：
  10.0

反应信息

• 作为产物：
  描述：

  硝基苯 在 吡啶 、 四氮唑 、 4-二甲氨基吡啶 、 1-羟基苯并三唑 、 溶剂黄146 、 N,N'-二环己基碳二亚胺 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 、 乙腈 为溶剂， 反应 73.0h， 生成 (2S,3S)-4-(bis(4-methoxyphenyl)(phenyl)methoxy)-3-(4-(phenyldiazenyl)benzamido)butan-2-yl (2-cyanoethyl) diisopropylphosphoramidite
  参考文献：
  名称：

  Structural stability of the photo-responsive DNA duplexes containing one azobenzene via a confined pore

  摘要：

  在此，基于α-溶血素纳米孔从混合物中分别检测了单个偶氮苯修饰的DNA双链的结构稳定性，包括trans形式和cis形式，根据它们可区分的解链动力学。

  DOI：

  10.1039/c7cc04599a

文献信息

• Single-molecule photon-fueled DNA nanoscissors for DNA cleavage based on the regulation of substrate binding affinity by azobenzene
  作者：Yuan Zou、Jie Chen、Zhi Zhu、Lianyu Lu、Yishun Huang、Yanling Song、Huimin Zhang、Huaizhi Kang、Chaoyong James Yang

  DOI：10.1039/c3cc44188a

  日期：——

  A pair of single-molecule photo-responsive DNA nanoscissors for DNA cleavage based on the regulation of substrate binding affinity was designed and fabricated. Compared with other DNA nanomachines, our DNA nanoscissors have the advantages of a clean switching mechanism, as well as robust and highly reversible operation.

  设计并制造了一对基于底物结合亲和力调节的单分子光响应DNA纳米剪刀，用于DNA切割。与其他DNA纳米机器相比，我们的DNA纳米剪刀具有干净的切换机制以及稳健且高度可逆的操作的优点。
• Macroscopic Volume Change of Dynamic Hydrogels Induced by Reversible DNA Hybridization
  作者：Lu Peng、Mingxu You、Quan Yuan、Cuichen Wu、Da Han、Yan Chen、Zhihua Zhong、Jiangeng Xue、Weihong Tan

  DOI：10.1021/ja305109n

  日期：2012.7.25

  Molecular recognition is fundamental to the specific interactions between molecules, of which the best known examples are antibody antigen binding and cDNA hybridization. Reversible manipulation of the molecular recognition events is still a very challenging topic, and such studies are often performed at the molecular level. An important consideration is the collection of changes at the molecular level to provide macroscopic observables. This research makes use of photoresponsive molecular recognition for the fabrication of novel photoregulated dynamic materials. Specifically, a dynamic hydrogel was prepared by grafting azobenzene-tethered ssDNA and its cDNA to the hydrogel network. The macroscopic volume Of the hydrogel can be manipulated through the photoreversible DNA hybridization controlled by alternate irradiation of UV and visible light. The effects of synthetic parameters including the concentration of DNA, polymer monomer, and permanent cross-linker are also discussed.
• A Time-Resolved Single-Molecular Train Based on Aerolysin Nanopore
  作者：Yi-Lun Ying、Zi-Yuan Li、Zheng-Li Hu、Junji Zhang、Fu-Na Meng、Chan Cao、Yi-Tao Long、He Tian

  DOI：10.1016/j.chempr.2018.05.004

  日期：2018.8

  An aerolysin nanopore interface was introduced as a molecular machine to electrically read out the real-time photo-controlled motion of an azobenzene-geared DNA train with high spatial and temporal resolution. Under alternating UV and visible irradiation, each DNA train performed two regulated speeds of 1.9 and 6.3 bases/s corresponding to trans and cis states, respectively, with readily identified current signals. Each train type fell into the ultra-narrow current population with a full-width half maximum of 0.2-0.4 pA. The combination of a model molecular machine system and powerful aerolysin interface enabled the motions of every artificial molecular machine to be followed in real time.