1-氯-2-(2-苯基乙基)苯 | 141552-11-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 中文名称: 1-氯-2-(2-苯基乙基)苯
• 英文名称: 2-chloro-bibenzyl
• 英文别名: 2-Chlor-bibenzyl；1-Chloro-2-(2-phenylethyl)benzene
• CAS: 141552-11-6
• 化学式: C₁₄H₁₃Cl
• 分子量: 216.71
• InChiKey: JCJXUIREMLMCQR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为产物：
  描述：

  (E)-2-chlorostilbene 在 乙醇 、 palladium(II)-hydroxide-barium sulfate-catalyst 作用下， 生成 1-氯-2-(2-苯基乙基)苯
  参考文献：
  名称：

  Alcohol Drinkers Overreport Their Energy Intake in the BIRNH Study: Evaluation by 24-Hour Urinary Excretion of Cations

  摘要：

  Objective: Alcohol drinkers are generally considered to underreport their alcohol intake, but little is known about whether they correctly report their energy intake (EI). We assessed the validity of the reported energy intake of alcohol drinkers using the 24-hour urinary (U) excretion of potassium (K) and sodium (Na) as biomarkers.Methods: A total of 2,124 men and 1,998 women 25 to 74 years of age with a 24-hour urine collection. a random sample of the Belgian Interuniversity Research on Nutrition and Health (BIRNH), were studied. Dietary intake (D), including alcohol consumption, was assessed by a one-day food record, Basal metabolic rate (BMR) was predicted from age gender and weight. As a measure for the degree of reporting error. D-K/U-K, D-Na/U-Na, EI/U-K, Non-alcohol EI/U-Na (NAEI/U-Na), Ei/U-Na, EVU-creatinine and EI/BMR ratios were calculated and compared among non-, moderate and heavy drinkers in both genders.Results: El, NAEI and all seven ratios examined generally increased with the level of alcohol intake in both genders. After adjustment for age, body mass index, smoking and educational level, most ratios were significantly higher in moderate drinkers (p < 0.02 to p < 0.0001) and in heavy drinkers (all p < 0.0001) than in non-drinkers. These differences were most significant in male heavy drinkers. The exceptions were D-K/U-K. D-Na/U-Na and NAEI/U-Na in moderate and female heavy drinkers and EI/U-K in male moderate drinkers. The estimated amount of the overreporting of El by heavy drinkers was 27.8% in men and 13.7% in women.Conclusions: This study provides evidence that El and NAEI obtained from the BIRNH study was overreported among alcohol drinkers, especially among male heavy drinkers. It also indicates that El from alcohol replaced El from food.

  DOI：

  10.1080/07315724.2001.10719060

文献信息

• [EN] AN IMPROVED PROCESS FOR DIASTER-EOSELECTIVE SYNTHESIS OF VICINAL DIAMINES<br/>[FR] PROCÉDÉ PERFECTIONNÉ POUR LA SYNTHÈSE DIASTÉRÉOSÉLECTIVE DE DIAMINES VICINALES
  申请人：PIRAMAL ENTPR LTD

  公开号：WO2020012403A1

  公开（公告）日：2020-01-16

  The present invention relates to an improved process for diastereoselective synthesis of vicinal diamines (1). The process involves highly regio- and diastereoselective addition of 2-azaallyl anions (4) to N-tert-butanesulfinylimines (5) to produce vicinal diamines (1).

  本发明涉及一种改进的对映选择性合成邻二胺（1）的方法。该方法涉及高度区域选择性和对映选择性地将2-氮烯基阴离子（4）加成到N-叔丁磺酰亚胺（5）上，以产生邻二胺（1）。