trans-3-ethoxycarbonyl-4(4'-fluorophenyl)piperidin-2,6-dione | 391937-08-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: trans-3-ethoxycarbonyl-4(4'-fluorophenyl)piperidin-2,6-dione
• 英文别名: 3-ethoxycarbonyl-4-(4-fluorophenyl)piperidine-2,6-dione；(+/-)-trans-3-Ethoxycarbonyl-4-(4'-fluorophenyl) piperidin-2,6-dione；ethyl 4-(4-fluorophenyl)-2,6-dioxopiperidine-3-carboxylate
• CAS: 391937-08-9
• 化学式: C₁₄H₁₄FNO₄
• 分子量: 279.268
• InChiKey: TWTXBOKSRNPUQL-UHFFFAOYSA-N

物化性质

• 沸点：
  443.9±45.0 °C(Predicted)
• 密度：
  1.281±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  72.5
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  trans-3-ethoxycarbonyl-4(4'-fluorophenyl)piperidin-2,6-dione 以 四氢呋喃 为溶剂， 以22%的产率得到[4-(4-氟苯基)-3-哌啶基]甲醇
  参考文献：
  名称：

  Process for preparing aryl-piperidine carbinols and novel intermediates

  摘要：

  公开了一种制备化合物的过程，其化学式为(I)：其中Ar是芳基或取代芳基，R.sup.3是氢、烷基或芳基烷基，该过程包括还原化合物的过程的化学式(II)：其中Ar和R.sup.3如与式(I)相关定义，R.sup.4是烷基。化合物的化学式(I)可用作化学中间体。

  公开号：

  US04902801A1

文献信息

• Process for preparing aryl-piperidine carbinols and novel intermediates
  申请人：Beecham Group plc.

  公开号：US04902801A1

  公开（公告）日：1990-02-20

  A process is disclosed for the preparation of a compound of formula (I): ##STR1## wherein Ar is aryl or substituted aryl and R.sup.3 is hydrogen, alkyl or aralkyl, which process comprises reducing a compound of formula (II): ##STR2## wherein Ar and R.sup.3 are as defined with respect to formula (I) and R.sup.4 is alkyl. Compounds of formula (I) are useful as chemical intermediates.

  公开了一种制备化合物的过程，其化学式为(I)：其中Ar是芳基或取代芳基，R.sup.3是氢、烷基或芳基烷基，该过程包括还原化合物的过程的化学式(II)：其中Ar和R.sup.3如与式(I)相关定义，R.sup.4是烷基。化合物的化学式(I)可用作化学中间体。
• Novel process
  申请人：SmithKline Beecham p.l.c.

  公开号：US20020010155A1

  公开（公告）日：2002-01-24

  A process for the preparation of a 4-aryl-3-oxymethyl-piperidine of structure (1) 1 in which R is hydrogen or an alkyl, arylalkyl, allyl, acyl, carbonyloxyalkyl, carbonyloxyaryl, or carbonyloxyalkylaryl group, and Y is a hydrogen atom or an optionally substituted alkyl, arylalkyl, or aryl group, from a carboxy derivative of structure (2) 2 where A is oxygen or sulphar, X is one or more of hydrogen, or a readily reducible group, Z represents either a hydrogen atom or an OY′ group in which Y′ is independently selected from the same groups as Y, and the broken line circle indicates bonding, appropriate to a tetrahydropyridine, dihydropyridine, pyridine, or piperidine ring said process comprising (a) when Y is a hydrogen atom, reducing the compound of structure (2), or (b) when Y is other than a hydrogen atom (i) forming an ether from the alcohol product of step (a), (ii) etherifying the aldehyde compound of structure (2) in which Z is hydrogen, or (iii) reducing the ester compound of structure (2) in which Z is OY′.

  一种制备结构（1）中的4-芳基-3-氧甲基-哌啶的方法，其中R是氢或烷基、芳基烷基、烯丙基、酰基、羰基氧烷基、羰基氧芳基或羰基氧烷基芳基，Y是氢原子或可选择取代的烷基、芳基烷基或芳基，从结构（2）中的羧衍生物进行，其中A是氧或硫，X是一个或多个氢或易还原基团，Z代表氢原子或OY′基团，其中Y′独立选择自Y相同的基团，中断线圆表示键合，适用于四氢吡啶、二氢吡啶、吡啶或哌啶环的过程包括(a)当Y是氢原子时，还原结构（2）的化合物，或(b)当Y不是氢原子时(i)从步骤（a）的醇产物中形成醚，(ii)使结构（2）中Z为氢的醛化合物醚化，或(iii)还原结构（2）中Z为OY′的酯化合物。
• Process for the preparation of aryl-piperidine carbinols
  申请人：BEECHAM GROUP PLC

  公开号：EP0223334A1

  公开（公告）日：1987-05-27

  A process is disclosed for the preparation of a compound of formula (I): wherein Ar is aryl or substituted aryl and R³ is hydrogen, alkyl or aralkyl, which process comprises reducing a compound of formula (II): wherein Ar and R³ are as defined with respect to formula (I) and R⁴ is alkyl. Compounds of formula (I) are useful as chemical intermediates.

  本发明公开了一种制备式(I)化合物的工艺： 其中 Ar 是芳基或取代芳基，R³ 是氢、烷基或芳烷基，该工艺包括还原式 (II) 的化合物： 其中 Ar 和 R³ 如式 (I) 所定义，R⁴ 是烷基。式 (I) 化合物可用作化学中间体。
• EP0223334B1
  申请人：——

  公开号：EP0223334B1

  公开（公告）日：1991-07-10
• EP223334
  申请人：——

  公开号：——

  公开（公告）日：——