[1-(4-Benzyloxycarbonylamino-2-fluoro-phenyl)-3-methyl-piperidin-4-yl]-methyl-carbamic acid tert-butyl ester | 866539-04-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: [1-(4-Benzyloxycarbonylamino-2-fluoro-phenyl)-3-methyl-piperidin-4-yl]-methyl-carbamic acid tert-butyl ester
• CAS: 866539-04-0
• 化学式: C₂₆H₃₄FN₃O₄
• 分子量: 471.572
• InChiKey: SBVTVNBAKIIRAZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.66
• 重原子数：
  34.0
• 可旋转键数：
  5.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  71.11
• 氢给体数：
  1.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  [1-(4-Benzyloxycarbonylamino-2-fluoro-phenyl)-3-methyl-piperidin-4-yl]-methyl-carbamic acid tert-butyl ester 在 正丁基锂 、 TEA 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 1.5h， 生成 Methanesulfonic acid (R)-3-{4-[4-(tert-butoxycarbonyl-methyl-amino)-3-methyl-piperidin-1-yl]-3-fluoro-phenyl}-2-oxo-oxazolidin-5-ylmethyl ester
  参考文献：
  名称：

  Synthesis and SAR of novel oxazolidinones: Discovery of ranbezolid

  摘要：

  Novel oxazolidinones were synthesized containing a number of substituted five-membered heterocycles attached to the 'piperazinyl-phenyl-oxazolidinone' core of eperezolid. Further, the piperazine ring of the core was replaced by other diamino-heterocycles. These modifications led to several compounds with potent activity against a spectrum of resistant and susceptible Gram-positive organisms, along with the identification of ranbezolid (RBx 7644) as a clinical candidate. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.06.063
• 作为产物：
  描述：

  [1-(2-Fluoro-4-nitro-phenyl)-3-methyl-piperidin-4-yl]-methyl-carbamic acid tert-butyl ester 在 palladium on activated charcoal 氢气 、 碳酸氢钠 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 20.0 ℃ 、379.21 kPa 条件下， 生成 [1-(4-Benzyloxycarbonylamino-2-fluoro-phenyl)-3-methyl-piperidin-4-yl]-methyl-carbamic acid tert-butyl ester
  参考文献：
  名称：

  Synthesis and SAR of novel oxazolidinones: Discovery of ranbezolid

  摘要：

  Novel oxazolidinones were synthesized containing a number of substituted five-membered heterocycles attached to the 'piperazinyl-phenyl-oxazolidinone' core of eperezolid. Further, the piperazine ring of the core was replaced by other diamino-heterocycles. These modifications led to several compounds with potent activity against a spectrum of resistant and susceptible Gram-positive organisms, along with the identification of ranbezolid (RBx 7644) as a clinical candidate. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.06.063