4-(4-Piperidin-4-ylphenyl)-2-propan-2-yl-1,2,4-triazol-3-one | 1092481-61-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 4-(4-Piperidin-4-ylphenyl)-2-propan-2-yl-1,2,4-triazol-3-one
• CAS: 1092481-61-2
• 化学式: C₁₆H₂₂N₄O
• 分子量: 286.377
• InChiKey: GHSJTIPOHPKLPR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  47.9
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-(4-Piperidin-4-ylphenyl)-2-propan-2-yl-1,2,4-triazol-3-one 、 2,6-二氯苯基异氰酸酯 以 二氯甲烷 为溶剂， 生成 N-(2,6-dichlorophenyl)-4-[4-(5-oxo-1-propan-2-yl-1,2,4-triazol-4-yl)phenyl]piperidine-1-carboxamide
  参考文献：
  名称：

  WO2008/148840

  摘要：

  公开号：
• 作为产物：
  描述：

  1-BOC-4-(4-氨基苯基)哌啶 在 盐酸 、 水 、 caesium carbonate 作用下， 以 N-甲基吡咯烷酮 、 二氯甲烷 、 N,N-二甲基乙酰胺 为溶剂， 反应 4.0h， 生成 4-(4-Piperidin-4-ylphenyl)-2-propan-2-yl-1,2,4-triazol-3-one
  参考文献：
  名称：

  WO2008/148840

  摘要：

  公开号：

文献信息

• PIPERIDINE/PIPERAZINE DERIVATIVES
  申请人：Janssen Pharmaceutica, N.V.

  公开号：EP2152271B1

  公开（公告）日：2015-10-21
• Mtp inhibiting aryl piperydines or piperazines substituted with 5-membered heterocycles
  申请人：Meerpoel Lieven

  公开号：US20070191383A1

  公开（公告）日：2007-08-16

  The present invention is concerned with novel aryl piperidine or piperazine compounds substituted with certain 5-membered heterocycles having apoB secretion/MTP inhibiting activity and concomitant lipid lowering activity. The invention further relates to methods for preparing such compounds, pharmaceutical compositions comprising said compounds as well as the use of said compounds as a medicine for the treatment of hyperlipidemia, obesity and type II diabetes. The invention further relates to methods for preparing such compounds, pharmaceutical compositions comprising said compounds as well as the use of said compounds as a medicine for the treatment of atherosclerosis, pancreatitis, obesity, hyper-triglyceridemia, hypercholesterolemia, hyperlipidemia, diabetes and type II diabetes.
• MTP INHIBITING ARYL PIPERIDINES OR PEPERAZINES SUBSTITUTED WITH5-MEMBERED HETEROCYCLES
  申请人：Meerpoel Lieven

  公开号：US20100004263A1

  公开（公告）日：2010-01-07

  The present invention is concerned with novel aryl piperidine or piperazine compounds substituted with certain 5-membered heterocycles having apoB secretion/MTP inhibiting activity and concomitant lipid lowering activity. The invention further relates to methods for preparing such compounds, pharmaceutical compositions comprising said compounds as well as the use of said compounds as a medicine for the treatment of hyperlipidemia, obesity and type II diabetes. The invention further relates to methods for preparing such compounds, pharmaceutical compositions comprising said compounds as well as the use of said compounds as a medicine for the treatment of atherosclerosis, pancreatitis, obesity, hypertriglyceridemia, hypercholesterolemia, hyperlipidemia, diabetes and type II diabetes.
• US7504400B2
  申请人：——

  公开号：US7504400B2

  公开（公告）日：2009-03-17
• US7816360B2
  申请人：——

  公开号：US7816360B2

  公开（公告）日：2010-10-19