6-bromo-5-methyl-2,3-dihydrobenzo[b][1,4]dioxine | 69464-39-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并二恶烷
• 英文名称: 6-bromo-5-methyl-2,3-dihydrobenzo[b][1,4]dioxine
• 英文别名: 6-Bromo-5-methyl-2,3-dihydro-1,4-benzodioxine
• CAS: 69464-39-7
• 化学式: C₉H₉BrO₂
• 分子量: 229.073
• InChiKey: RZIQLZJWVWXWMB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  6-bromo-5-methyl-2,3-dihydrobenzo[b][1,4]dioxine 、 potassium permanganate 以29%的产率得到
  参考文献：
  名称：

  DAUKSHAS V. K.; BALYAVICHYUS L. Z.; UDRENAJTE EH. B.; PURVANEUKAS G. V.; +, XIMIYA GETEROTSIKL. SOEDIN., 1978, HO 11, 1465-1471

  摘要：

  DOI：
• 作为产物：
  描述：

  3-甲基苯邻二酚 在 N-溴代丁二酰亚胺(NBS) 、 potassium carbonate 作用下， 以 乙二醇 、 乙腈 为溶剂， 反应 144.0h， 生成 6-bromo-5-methyl-2,3-dihydrobenzo[b][1,4]dioxine
  参考文献：
  名称：

  COMPOUNDS USEFUL AS IMMUNOMODULATORS

  摘要：

  本发明公开一般涉及可用作免疫调节剂的化合物。本发明提供了化合物、包含此类化合物的组合物及其使用方法。本发明还涉及包含至少一种根据本发明的化合物的药物组合物，这些药物组合物可用于治疗各种疾病，包括癌症和传染病。

  公开号：

  US20170107202A1

文献信息

• COMPOUNDS FOR TREATMENT OF PD-L1 DISEASES
  申请人：CHEMOCENTRYX, INC.

  公开号：US20210002229A1

  公开（公告）日：2021-01-07

  Compounds are provided that are useful as immunomodulators. The compounds have the Formula (I) including stereoisomers and pharmaceutically acceptable salts thereof, wherein R 1a , R 1b , R 1c , R 1d , R 2a , R 2b , R 3 , R 3a , R 4 , R 5 , R 6 , R 7 , R 8 and the subscript n are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

  提供了一些作为免疫调节剂有用的化合物。这些化合物具有式(I)，包括立体异构体和其药用可接受盐，其中R1a、R1b、R1c、R1d、R2a、R2b、R3、R3a、R4、R5、R6、R7、R8和下标n如本文所定义。还公开了与制备和使用这些化合物相关的方法，以及包含这些化合物的药物组合物。
• New hydrazine derivative and pesticidal composition comprising said
  申请人：Nippon Kayaku Kabushiki Kaisha

  公开号：US05378726A1

  公开（公告）日：1995-01-03

  A novel hydrazine derivative and a pesticidal composition containing the hydrazine derivative as the effecting ingredient. The hydrazine derivative show high pesticidal activity against harmful pests which are resistant to known pesticides such as organophosphorus pesticides, pyrethroids, etc., especially against Lepidopters harmful pests such as Plutella xylostella, Spodoptera litura, Cnaphalocrocis medinalis, Adoxophyes orana, etc., and is effective for controlling harmful pests in paddy field, upland field, orchard, forest or places to be kept environmentally hygienic.

  一种新的肼衍生物及其作为杀虫剂的组合物。该肼衍生物对抗有抗性的害虫表现出高效的杀虫活性，如对小菜蛾、棉铃虫、稻纵卷叶螟、苹果小食心虫等有害害虫尤为有效，可用于稻田、旱地、果园、森林或需要环境卫生的地方控制有害害虫。
• Hydrazine derivative and pesticidal composition comprising said
  申请人：Nippon Kayaku Kabushiki Kaisha

  公开号：US05530021A1

  公开（公告）日：1996-06-25

  A novel hydrazine derivative and a pesticidal composition containing the hydrazine derivative as the effecting ingredient. The hydrazine derivative show high pesticidal activity against harmful pests which are resistant to known pesticides such as organophosphorus pesticides, pyrethroids, etc., especially against Lepidoptera harmful pests such as Plutella xylostella, Spodoptera litura, Cnaphalocrocis medinalis, Adoxophyes orana, etc., and is effective for controlling harmful pests in paddy field, upland field, orchard, forest or places to be kept environmentally hygienic.

  一种新的肼衍生物以及含有该肼衍生物作为有效成分的杀虫组合物。该肼衍生物对于已知杀虫剂如有机磷杀虫剂、拟除虫菊酯等对抗性害虫表现出高效的杀虫活性，特别是对于小菜蛾、棉铃虫、稻纵卷叶螟、苹果蛾等鳞翅目害虫表现出高效，并且在稻田、旱田、果园、森林或环境卫生需要保持的地方控制害虫十分有效。
• [EN] MACROCYCLES AS CFTR MODULATORS<br/>[FR] MACROCYCLES EN TANT QUE MODULATEURS DE CFTR
  申请人：IDORSIA PHARMACEUTICALS LTD

  公开号：WO2022194399A1

  公开（公告）日：2022-09-22

  The present invention relates to macrocyclic compounds of Formula (I) wherein Ar1, Ar2, R1, R2, R3, R4, and X are as described in the description, their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of Formula (I), and especially to their use as modulators of CFTR.

  本发明涉及公式（I）的大环化合物，其中Ar1，Ar2，R1，R2，R3，R4和X如描述中所述，它们的制备方法，其药学上可接受的盐以及它们作为药物的用途，包括含有一个或多个公式（I）化合物的药物组合物，特别是它们作为CFTR调节剂的用途。
• New hydrazine derivative and pesticidal composition comprising said derivative as an effective ingredient
  申请人：Nippon Kayaku Kabushiki Kaisha

  公开号：EP0496342A1

  公开（公告）日：1992-07-29

  A novel hydrazine derivative represented by the following formula (I): where R¹ -R¹²,A,B and n are as defined in Claim 1, and a pesticidal composition containing the hydrazine derivative as the effecting ingredient. The hydrazine derivative show high pesticidal activity against harmful pests which are resistant to known pesticides such as organophosphorus pesticides, pyrethroids, etc., especially against Lepidopters harmful pests such as Plutella xylostella, Spodoptera litura, Cnaphalocrocis medinalis, Adoxophyes orana, etc., and is effective for controlling harmful pests in paddy field, upland field, orchard, forest or places to be kept environmentally hygienic.

  由下式(I)代表的新型肼衍生物： 其中 R¹ -R¹²、A、B 和 n 如权利要求 1 所定义，以及含有该肼衍生物作为有效成分的杀虫组合物。该肼衍生物对已知农药如有机磷农药、拟除虫菊酯类等具有抗性的有害害虫具有很高的杀虫活性，特别是对鳞翅目有害害虫如木虱Plutella xylostella、鞘翅目Spodoptera litura、褐飞虱Cnaphalocrocis medinalis、褐飞虱Adoxophyes orana等具有很高的杀虫活性，可有效防治水田、高地、果园、森林或需要保持环境卫生的地方的有害害虫。