Substituted pyrrolo [1,2-c] quinazolines and pharmaceutical compositions
申请人:Ortho Pharmaceutical Corporation
公开号:US04129653A1
公开(公告)日:1978-12-12
Substituted pyrrolo[1,2-c] quinazolines useful for their cardiovascular activities and as antiasthmatic agents.
用于心血管活动和抗哮喘药物的吡咯并[1,2-c]喹唑啉的替代物。
US4129653A
申请人:——
公开号:US4129653A
公开(公告)日:1978-12-12
Antihypertensive pyrrolo[1,2-c]quinazolines and pyrrolo[1,2-c]quinazolinones
作者:Victor T. Bandurco、Elizabeth Malloy Wong、Seymour D. Levine、Zoltan G. Hajos
DOI:10.1021/jm00144a017
日期:1981.12
The synthesis of a variety of pyrrolo[1,2-c]quinazolines and pyrrolo[1,2-c]quinazolinones is described. Several of these compounds have exhibited antihypertensive properties in the spontaneously hypertensive rat (SHR). Structure-activity comparisons have indicated that optimal activity is obtained in both the 2-carbethoxydihydroquinazoline series (C) and 2-carbethoxyquinazolinone series (D) when there