1-chloro-2-nitronaphthalene | 607-22-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1-chloro-2-nitronaphthalene
• 英文别名: 1-chloro-2-nitro-naphthalene；1-Chlor-2-nitro-naphthalin；1-Chlor-2-nitro-naphtalin；1-Chlor-2-nitronaphthalin
• CAS: 607-22-7
• 化学式: C₁₀H₆ClNO₂
• 分子量: 207.616
• InChiKey: VMADQUDNIAMBCH-UHFFFAOYSA-N

物化性质

• 沸点：
  353.1±15.0 °C(Predicted)
• 密度：
  1.409±0.06 g/cm3(Predicted)
• 熔点：
  76 °C

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  45.8
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-chloro-2-nitronaphthalene 在 氢氧化钾 作用下， 生成 2-硝基-1-萘酚
  参考文献：
  名称：

  12. 4-硝基-1-萘甲基醚和4-硝基-1-萘乙基醚分别与乙醇钠和甲醇钠的交换反应，以及某些1-硝基萘衍生物的还原

  摘要：

  DOI：

  10.1039/jr9420000045
• 作为产物：
  描述：

  2-硝基-1-萘酚 在 ammonium carbonate 、 氨 、 水 作用下， 生成 1-chloro-2-nitronaphthalene
  参考文献：
  名称：

  Hodgson; Kilner, Journal of the Chemical Society, 1926, p. 8

  摘要：

  DOI：

文献信息

• IRON OXIDE SUPPORTED RHODIUM CATALYST FOR NITROARENE REDUCTION
  申请人：King Fahd University of Petroleum and Minerals

  公开号：US20200298212A1

  公开（公告）日：2020-09-24

  A supported catalyst having rhodium particles with an average diameter of less than 1 nm disposed on a support material containing magnetic iron oxide (e.g. Fe 3 O 4 ). A method of producing the supported catalyst and a process of reducing nitroarenes to corresponding aromatic amines employing the supported catalyst with a high product yield are also described. The supported catalyst may be recovered with ease using an external magnet and reused.

  一个支撑的催化剂，其上分布有平均直径小于1纳米的铑颗粒，载体材料含有磁性氧化铁（例如Fe3O4）。还描述了生产该支撑催化剂的方法以及使用该支撑催化剂将硝基芳烃还原为相应芳香胺的过程，该过程具有高产品收率。可以使用外部磁铁轻松回收支撑催化剂，并重复使用。
• Synthesis and Muscarinic Activity of a Series of Quinolines and Naphthalenes with a 1-Azabicyclo(3.3.0)octane Moiety.
  作者：Tomoo SUZUKI、Toshinao USUI、Mitsuru OKA、Tsunemasa SUZUKI、Tadashi KATAOKA

  DOI：10.1248/cpb.46.1265

  日期：——

  synthesized a series of quinoline derivatives having a characteristic 1-azabicyclo[3.3.0]octane amine ring, and performed pharmacological evaluation of them. Acetylcholine esterase inhibitory activities of these derivatives were unexpectedly weak. Tests for central nervous muscarinic cholinergic receptor binding affinity indicated that these compounds had higher affinities to muscarinic M1 receptors than to

  为了发现对阿尔茨海默氏病有效的药物，我们合成了一系列具有特征性的1-氮杂双环[3.3.0]辛烷胺环的喹啉衍生物，并对其进行了药理学评价。这些衍生物的乙酰胆碱酯酶抑制活性出乎意料地弱。对中枢神经毒蕈碱胆碱能受体结合亲和力的测试表明，这些化合物对毒蕈碱M1受体的亲和力高于对M2受体的亲和力。还合成了一系列被1-氮杂双环[3.3.0]辛烷环取代的萘衍生物，并确定了毒蕈碱M1和M2受体的结合亲和力。这些化合物对M1受体的亲和力比喹啉衍生物和1- [N-（1-氮杂双环[3.3]。0]辛基-5-基）甲基-N-甲基氨基] -4-硝基萘具有最高的亲和力和选择性。使用东avoid碱诱导的小鼠的被动回避测试评估了该化合物改善认知功能的能力。
• Nootropic agents, compositions of, and method of use thereof
  申请人：Sanawa Kagaku Kenkyusho Company, Ltd.

  公开号：US05434165A1

  公开（公告）日：1995-07-18

  An aromatic amino-substituted compound represented by formula: ##STR1## wherein A represents CH, N, or N.fwdarw.O; R.sub.1 represents a nitro group or an amino group; R.sub.2 represents a hydrogen atom, a lower alkyl group, or an acyl group; and R.sub.3 represents a group: ##STR2## wherein m represents 0 or 1; n represents an integer of from 0 to 3; R.sub.4 and R.sub.5 each represents a hydrogen atom or a lower alkyl group; R.sub.6 and R.sub.7 each represents a hydrogen atom or a straight chain or branched lower alkyl group; R.sub.4 and R.sub.6 may be joined together to form an alkylene chain forming a heterocyclic ring; R.sub.5 and R.sub.7 may be joined together to form an alkylene chain forming a heterocyclic ring and R.sub.6 and R.sub.7 may be joined together to form an alkylene chain forming a heterocyclic ring, or a pharmaceutically acceptable salt thereof, a process for producing the same, and a method for preventing or treating brain disfunction such as senile dementia or Alzheimer's disease by administering a nootropic agent containing the same as an active ingredient are disclosed.

  一种芳香族氨基取代化合物，其化学式表示为：##STR1## 其中A代表CH、N或N.fwdarw.O；R.sub.1代表硝基基团或氨基团；R.sub.2代表氢原子、较低的烷基基团或酰基团；R.sub.3代表一个基团：##STR2## 其中m表示0或1；n表示0到3的整数；R.sub.4和R.sub.5分别代表氢原子或较低的烷基基团；R.sub.6和R.sub.7分别代表氢原子或直链或支链较低的烷基基团；R.sub.4和R.sub.6可以结合在一起形成形成杂环环的烷基链；R.sub.5和R.sub.7可以结合在一起形成形成杂环环的烷基链，R.sub.6和R.sub.7可以结合在一起形成形成杂环环的烷基链，或其药学上可接受的盐，公开了一种制备该化合物的方法，以及通过给予含有该化合物作为活性成分的智力药剂来预防或治疗脑功能障碍，如老年性痴呆症或阿尔茨海默病的方法。
• Selective hydrogenation of nitro groups of halonitro aromatic compounds
  申请人：Liu Changkun

  公开号：US20070049772A1

  公开（公告）日：2007-03-01

  A supported catalyst for hydrogenating nitro groups of halonitro compounds manufactured from a support, a solvent, and a plurality of organometallic complexes. The organometallic complexes have the formula: wherein, R 1 -R 6 , are independently an R, OR, OC(═O)R, halogen, or combination thereof, where R stands for an alkyl or aryl group; Y 1 -Y 4 are independently an O, S, N, or P atom; and M is a metal atom. The supported catalysts show much higher selectivity and activity when used to hydrogenate nitro groups on halonitro aromatic compounds than catalyst currently being used for such hydrogenation.

  一种用于氢化卤代硝基化合物的支撑催化剂，由支撑体、溶剂和多种有机金属配合物制成。有机金属配合物的化学式为：其中，R1-R6独立地是R、OR、OC（═O）R、卤素或其组合，其中R代表烷基或芳基基团；Y1-Y4独立地是O、S、N或P原子；M是金属原子。使用这种支撑催化剂氢化卤代硝基芳香化合物的选择性和活性比目前用于此类氢化反应的催化剂高得多。
• Process for making nitrodiarylamines
  申请人：Monsanto Company

  公开号：EP0148145A1

  公开（公告）日：1985-07-10

  Nitrodiarylamines are produced by the addition to a nitrohaloarene at condensation temperature for forming nitrodiarylamines, of a sodium, potassium, rubidium or cesium salt of the formyl derivative of an aromatic amine.

  硝基二芳基胺是在形成硝基二芳基胺的缩合温度下，将芳香胺甲酰基衍生物的钠、钾、铷或铯盐加到硝基卤代烃中生成的。