[EN] PREPARATION OF DIHYDROTHIENO [3, 2-D] PYRIMIDINES AND INTERMEDIATES USED THEREIN [FR] PRÉPARATION DE DIHYDROTHIÉNOPYRIMIDINES ET D'INTERMÉDIAIRES UTILISÉS LORS DE CELLE-CI
[EN] PREPARATION OF DIHYDROTHIENO [3, 2-D] PYRIMIDINES AND INTERMEDIATES USED THEREIN [FR] PRÉPARATION DE DIHYDROTHIÉNOPYRIMIDINES ET D'INTERMÉDIAIRES UTILISÉS LORS DE CELLE-CI
PREPARATION OF DIHYDROTHIENO [3, 2-D] PYRIMIDINES AND INTERMEDIATES USED THEREIN
申请人:Frutos Rogelio
公开号:US20100222585A1
公开(公告)日:2010-09-02
The invention relates to improved methods of preparing dihydrothienopyrimidines of formula 1, and intermediates thereof, (I) wherein X is SO or SO
2
, preferably SO, and wherein R
A
, R
1
, R
2
, R
3
, R
4
and R
5
have the meanings given in the description. The methods according to this invention are more suitable for large-scale synthesis of said pounds than prior methods because the new synthetic process avoids distillation and chromatographic purification between steps and results in a higher overall yield of the desired product.