(1S,2R)-(2-butyl-1,2-dihydronaphthyl)methan-1-ol | 99797-52-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: (1S,2R)-(2-butyl-1,2-dihydronaphthyl)methan-1-ol
• 英文别名: [(1S,2R)-2-butyl-1,2-dihydronaphthalen-1-yl]methanol
• CAS: 99797-52-1
• 化学式: C₁₅H₂₀O
• 分子量: 216.323
• InChiKey: SSHGZGRHFHVSAK-HIFRSBDPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (1S,2R)-(2-butyl-1,2-dihydronaphthyl)methan-1-ol 生成 ((1S,2R)-2-Butyl-1,2-dihydro-naphthalen-1-yl)-acetonitrile
  参考文献：
  名称：

  Bai Xu, Mascarella S. Wayne, Bowen Wayne D., Carroll F. Ivy,, J. Chem. Soc. Chem. Commun, (1994) N 20, S 2401-2402

  摘要：

  DOI：
• 作为产物：
  描述：

  ((S)-1-tert-Butoxymethyl-2-methyl-propyl)-[1-naphthalen-1-yl-meth-(E)-ylidene]-amine 在 盐酸 、 异丙醇 作用下， 反应 3.0h， 生成 (1S,2R)-(2-butyl-1,2-dihydronaphthyl)methan-1-ol
  参考文献：
  名称：

  Asymmetric synthesis of 1,1,2- and 1,2-substituted dihydronaphthalenes via a chiral naphthyl imine

  摘要：

  DOI：

  10.1016/s0040-4039(00)96708-x

文献信息

• A novel asymmetric synthesis of 3-benzyl-1,2,3,4,5,6-hexahydro-11-alkyl-2,6-methano-3-benzazocines
  作者：Xu Bai、S. Wayne Mascarella、Wayne D. Bowen、F. Ivy Carroll

  DOI：10.1039/c39940002401

  日期：——

  9-Alkyl 6,7-benzomorphans (1,2,3,4,5,6-hexahydro-11-alkyl-2,6-methano-3-benzazocines) are important selective ligands of sigma receptor sites; their asymmetric synthesis starting with (1R, 2R)- or (1S, 2S)-1-hydroxymethyl-2-alkyl-2-alkyl-1,2-dihydronaphthalene is described.

  9-烷基-6,7-苄莫沙芬（1,2,3,4,5,6-六氢-11-烷基-2,6-亚甲基-3-苄唑辛）是σ受体位点的重要选择性配体；以（1R, 2R）-或（1S, 2S）-1-羟甲基-2-烷基-2-烷基-1,2-二氢萘为起始原料的不对称合成方法已被描述。
• Asymmetric additions to chiral naphthalenes. III. The synthesis of (+)-trans-1,2-disubstituted-1,2-dihydronaphthalenes
  作者：A. I. Meyers、Bruce A. Barner

  DOI：10.1021/jo00351a034

  日期：1986.1
• Design, Synthesis, and Application of a <i>C</i>₂ Symmetric Chiral Ligand for Enantioselective Conjugate Addition of Organolithium to α,β-Unsaturated Aldimine
  作者：Mitsuru Shindo、Kenji Koga、Kiyoshi Tomioka

  DOI：10.1021/jo9813181

  日期：1998.12.1

  A C-2 symmetric chiral diether ligand, (1R,2R)-1,2-dimethoxy-1,2-diphenylethane was designed and synthesized on the basis of the concept of an asymmetric oxygen atom. Mediated by the chiral diether, high enantioselectivities were achieved in conjugate addition of organolithiums to naphthaldehyde imine and cyclic and acyclic alpha,beta-unsaturated aldimines. The absolute configuration of the product is predictable by the model.
• Novel strategy of using a C2 symmetric chiral diether in the enantioselective conjugate addition of an organolithium to an .alpha.,.beta.-unsaturated aldimine
  作者：Kiyoshi Tomioka、Mitsuru Shindo、Kenji Koga

  DOI：10.1021/ja00203a032

  日期：1989.10
• TOMOIOKA, KIYOSHI;SHINDO, MITSURU;KOGA, KENJI, J. AMER. CHEM. SOC., 111,(1989) N1, C. 8266-8268
  作者：TOMOIOKA, KIYOSHI、SHINDO, MITSURU、KOGA, KENJI

  DOI：——

  日期：——