3-(乙酰氨基)-2-萘甲酸 | 19717-59-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 中文名称: 3-(乙酰氨基)-2-萘甲酸
• 英文名称: 3-acetamido-2-naphthoic acid
• 英文别名: 3-acetylamino-naphthalene-2-carboxylic acid；3-acetylamino-[2]naphthoic acid；3-Acetylamino-[2]naphthoesaeure；3-Acetamino-naphthoesaeure-(2)；3-acetylamino-2-naphthoic acid；3-Acetamino-2-naphthoesaeure；3-(Acetylamino)-2-naphthoic acid；3-acetamidonaphthalene-2-carboxylic acid
• CAS: 19717-59-0
• 化学式: C₁₃H₁₁NO₃
• mdl: MFCD07692303
• 分子量: 229.235
• InChiKey: FHXRDNPWHSTOGC-UHFFFAOYSA-N

物化性质

• 沸点：
  482.2±28.0 °C(Predicted)
• 密度：
  1.355±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.076
• 拓扑面积：
  66.4
• 氢给体数：
  2
• 氢受体数：
  3

安全信息

• 海关编码：
  2924299090

SDS

Material Safety Data Sheet

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Section 1. Identification of the substance
Product Name: 3-Acetamidonaphthoic acid
Synonyms: 3-Acetamidonaphthalene-2-carboxylic acid

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Section 2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.

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Section 3. Composition/information on ingredients.
Ingredient name: 3-Acetamidonaphthoic acid
CAS number: 19717-59-0

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Section 4. First aid measures
Skin contact: Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact: Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation: Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion: Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

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Section 5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

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Section 6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution: Wear approved mask/respirator
Hand precaution: Wear suitable gloves/gauntlets
Skin protection: Wear suitable protective clothing
Eye protection: Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

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Section 7. Handling and storage
Handling: This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Store in closed vessels.
Storage:

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Section 8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

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Section 9. Physical and chemical properties
Appearance: Not specified
Boiling point: No data
No data
Melting point:
Flash point: No data
Density: No data
Molecular formula: C13H11NO3
Molecular weight: 229.2

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Section 10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides.

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Section 11. Toxicological information
No data.

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Section 12. Ecological information
No data.

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Section 13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

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Section 14. Transportation information
Non-harzardous for air and ground transportation.

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Section 15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  3-(乙酰氨基)-2-萘甲酸 在 氨 、 水 作用下， 反应 12.0h， 生成 2-methylbenzo[g]quinazolin-4(3H)-one
  参考文献：
  名称：

  喹唑啉作为细菌细胞分裂蛋白 FtsZ 抑制剂的合成和评价。

  摘要：

  细菌细胞分裂蛋白 FtsZ 是开发新型抗生素的众多潜在目标之一。最近，zantrin Z3 被证明是 FtsZ 的跨物种抑制剂；然而，它与蛋白质的特定相互作用仍然未知。在此，我们报告了包含更易处理的核心结构的类似物的合成，以及对 FtsZ 的 GTPase 活性具有个位数微摩尔抑制的类似物，这是迄今为止报道的最有效的大肠杆菌FtsZ抑制剂。此外，zantrin Z3 核心已转化为两种潜在的光交联试剂，用于蛋白质组学研究，可以阐明 FtsZ 与与 zantrin Z3 相关的分子之间的分子相互作用。

  DOI：

  10.1021/ml500497s
• 作为产物：
  描述：

  2-methyl-4H-naphth<2,3-d><1,3>oxazin-4-one 在 水 作用下， 生成 3-(乙酰氨基)-2-萘甲酸
  参考文献：
  名称：

  Vicens, Jacques; Decoret, Claude; Gaget, Christine, Molecular Crystals and Liquid Crystals (1969-1991), 1983, vol. 96, p. 39 - 44

  摘要：

  DOI：

文献信息

• Antipicornaviral compounds and compositions, their pharmaceutical uses, and materials for their synthesis
  申请人：——

  公开号：US20020061916A1

  公开（公告）日：2002-05-23

  Compounds of the formula: 1 where the formula variables are as defined in the disclosure, advantageously inhibit or block the biological activity of the picornaviral 3C protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with one or more picornaviruses, such as RVP. Intermediates and synthetic methods for preparing such compounds are also described.

  公式为1的化合物，其中公式变量如披露所定义，有利地抑制或阻断了小肠病毒3C蛋白酶的生物活性。这些化合物以及含有这些化合物的制药组合物，对于治疗感染了一个或多个小肠病毒（如RVP）的患者或宿主是有用的。还描述了制备这些化合物的中间体和合成方法。
• THERAPEUTIC COMPOUNDS
  申请人：Fibrotech Therapeutics Pty Ltd

  公开号：US20140357628A1

  公开（公告）日：2014-12-04

  Substituted cinnamoyl anthranilate compounds exhibiting anti-fibrotic activity; or derivatives thereof, analogues thereof, pharmaceutically acceptable salts thereof, and metabolites thereof, with the proviso that the compound is no Tranilast.

  具有抗纤维化活性的替代肉桂酰基蒽酸酯化合物；或其衍生物、类似物、药学上可接受的盐以及代谢物，但前提是该化合物不是曲安奈德。
• METHOD FOR PREPARING WHOLLY AROMATIC LIQUID CRYSTALLINE POLYESTER AMIDE RESIN AND METHOD FOR PREPARING WHOLLY AROMATIC LIQUID CRYSTALLINE POLYESTER AMIDE RESIN COMPOUND
  申请人：Samsung Fine Chemicals Co., Ltd.

  公开号：EP2644639A2

  公开（公告）日：2013-10-02

  A method of preparing a wholly aromatic liquid crystalline polyester amide resin and a method of preparing a wholly aromatic liquid crystalline polyester amide resin compound. The method of preparing a wholly aromatic liquid crystalline polyester amide resin is performed using a monomer having both a hydroxyl group and an acetylamino group or using a monomer having a hydroxyl group and a monomer having an acetylamino group. In addition, the method of preparing a wholly aromatic liquid crystalline polyester amide resin compound is performed using a wholly aromatic liquid crystalline polyester amide resin that is prepared using the method.

  一种制备全芳香族液晶聚酯酰胺树脂的方法和一种制备全芳香族液晶聚酯酰胺树脂化合物的方法。全芳香族液态结晶聚酯酰胺树脂的制备方法使用同时具有羟基和乙酰氨基的单体，或使用具有羟基和乙酰氨基的单体。此外，全芳香族液态结晶聚酯酰胺树脂化合物的制备方法可使用使用该方法制备的全芳香族液态结晶聚酯酰胺树脂。
• Fries; Walter; Schilling, Justus Liebigs Annalen der Chemie, 1935, vol. 516, p. 248,262
  作者：Fries、Walter、Schilling

  DOI：——

  日期：——
• Egg Production, Fertility, and Hatchability of Breeder Hens Receiving Dietary Phytase
  作者：W.D. Berry、J.B. Hess、R.J. Lien、D.A. Roland

  DOI：10.1093/japr/12.3.264

  日期：2003.10

  An experiment was conducted to determine whether supplemental dietary phytase could support egg production, egg shell quality, fertility, and hatchability in broiler breeder hens on a diet with marginal available phosphorus. During the production period, 27 to 60 wk of age, individually caged broiler breeder hens; were fed four diets with two available phosphorus (AP) concentrations (0.1 and 0.3%) and two phytase levels [0 and 300 phytase units (FTU)/kg]. Phytase increased overall hen-day egg production by 9.8%, as compared with hens consuming a low phosphorus diet without added phytase. Addition of phytase significantly reduced hen mortality regardless of AP levels. Phytase improved bone mineral content and bone density of hens at both AP levels. Supplemental phytase had no significant effect on egg weight or egg specific gravity. The results suggest the possibility of a detrimental interaction of phytase with the 0.1 AP level on hatchability.