[4-(6-Chloropyridazin-3-yl)piperazin-1-yl]-(furan-2-yl)methanone | 192525-43-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: [4-(6-Chloropyridazin-3-yl)piperazin-1-yl]-(furan-2-yl)methanone
• CAS: 192525-43-2
• 化学式: C₁₃H₁₃ClN₄O₂
• 分子量: 292.725
• InChiKey: OMRYWLKMMXXURG-UHFFFAOYSA-N

物化性质

• 沸点：
  546.8±50.0 °C(Predicted)
• 密度：
  1.387±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  62.5
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  [4-(6-Chloropyridazin-3-yl)piperazin-1-yl]-(furan-2-yl)methanone 在 sodium hydroxide 作用下， 以 乙醇 、 溶剂黄146 为溶剂， 反应 11.0h， 生成 6-[4-(Furan-2-carbonyl)piperazin-1-yl]-2-[3-[4-(2-methoxyphenyl)piperazin-1-yl]propyl]pyridazin-3-one
  参考文献：
  名称：

  New 3(2H)-pyridazinone derivatives: synthesis and affinity towards α1AR subtypes and 5HT1A receptors

  摘要：

  The synthesis and the evaluation of the radioreceptor binding affinity of a series of 3(2H)-pyridazinone derivatives is reported. Their affinity towards the alpha(1) receptor, three alpha(1)-AR subtype (alpha(1a),alpha(1b),alpha(1d)) receptors and the 5HT(1A) receptor has been determined. The results of the affinity on alpha(1)-AR subtypes and the 5HT(1A)/alpha(1) selectivity are discussed.

  DOI：

  10.1016/s0223-5234(97)89086-1
• 作为产物：
  描述：

  3,6-二氯哒嗪 、 1-(2-糠酰)哌嗪 在 potassium carbonate 作用下， 以 丁酮 为溶剂， 反应 17.0h， 以56%的产率得到[4-(6-Chloropyridazin-3-yl)piperazin-1-yl]-(furan-2-yl)methanone
  参考文献：
  名称：

  New 3(2H)-pyridazinone derivatives: synthesis and affinity towards α1AR subtypes and 5HT1A receptors

  摘要：

  The synthesis and the evaluation of the radioreceptor binding affinity of a series of 3(2H)-pyridazinone derivatives is reported. Their affinity towards the alpha(1) receptor, three alpha(1)-AR subtype (alpha(1a),alpha(1b),alpha(1d)) receptors and the 5HT(1A) receptor has been determined. The results of the affinity on alpha(1)-AR subtypes and the 5HT(1A)/alpha(1) selectivity are discussed.

  DOI：

  10.1016/s0223-5234(97)89086-1

文献信息

• New 3(2H)-pyridazinone derivatives: synthesis and affinity towards α1AR subtypes and 5HT1A receptors
  作者：S Corsano、G Strappaghetti、A Leonardi、K Rhazri、R Barbaro

  DOI：10.1016/s0223-5234(97)89086-1

  日期：1997.1

  The synthesis and the evaluation of the radioreceptor binding affinity of a series of 3(2H)-pyridazinone derivatives is reported. Their affinity towards the alpha(1) receptor, three alpha(1)-AR subtype (alpha(1a),alpha(1b),alpha(1d)) receptors and the 5HT(1A) receptor has been determined. The results of the affinity on alpha(1)-AR subtypes and the 5HT(1A)/alpha(1) selectivity are discussed.