十二烷基三甲氧基硅烷 | 3069-21-4

• 物质功能分类: 化学试剂 - 有机试剂 - 硅氧烷
• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 中文名称: 十二烷基三甲氧基硅烷
• 中文别名: 正十二烷基三甲氧基硅烷；N-十二烷基三甲氧基硅烷；硅烷偶联剂WD-10；n-十二烷基三甲氧基硅烷
• 英文名称: n-dodecyltrimethoxysilane
• 英文别名: dodecyltrimethoxysilane；trimethoxydodecylsilan；CH3(CH2)11Si(OMe)3；Trimethox-dodecyl-silan；dodecyl(trimethoxy)silane
• CAS: 3069-21-4
• 化学式: C₁₅H₃₄O₃Si
• mdl: MFCD00069148
• 分子量: 290.519
• InChiKey: SCPWMSBAGXEGPW-UHFFFAOYSA-N

物化性质

• 熔点：
  -40°C
• 沸点：
  125 °C
• 密度：
  0.89
• 闪点：
  108°C
• 稳定性/保质期：
  遵照规定使用和储存，则不会分解。

计算性质

• 辛醇/水分配系数(LogP)：
  4.98
• 重原子数：
  19
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  27.7
• 氢给体数：
  0
• 氢受体数：
  3

安全信息

• 安全说明：
  S26,S36/37/39
• 危险类别码：
  R36/38
• 海关编码：
  2931900090
• 危险性防范说明：
  P264,P280,P302+P352+P332+P313+P362+P364,P305+P351+P338+P337+P313
• 危险性描述：
  H315,H319

SDS

Dodecyltrimethoxysilane Revision number: 5
SAFETY DATA SHEET

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Section 1. IDENTIFICATION
Product name: Dodecyltrimethoxysilane

Revision number: 5

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Section 2. HAZARDS IDENTIFICATION
GHS classification
PHYSICAL HAZARDS Not classified
HEALTH HAZARDS
Skin corrosion/irritation Category 2
Category 2A
Serious eye damage/eye irritation
ENVIRONMENTAL HAZARDS Not classified
GHS label elements, including precautionary statements
Pictograms or hazard symbols
Signal word Warning
Hazard statements Causes skin irritation
Causes serious eye irritation
Precautionary statements:
Wash hands thoroughly after handling.
[Prevention]
Wear protective gloves/eye protection/face protection.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses,
[Response]
if present and easy to do. Continue rinsing.
If eye irritation persists: Get medical advice/attention.
IF ON SKIN: Gently wash with plenty of soap and water.
If skin irritation occurs: Get medical advice/attention.
Take off contaminated clothing and wash before reuse.

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Section 3. COMPOSITION/INFORMATION ON INGREDIENTS
Substance/mixture: Substance
Components: Dodecyltrimethoxysilane
Percent: >93.0%(GC)
CAS Number: 3069-21-4
Synonyms: Lauryltrimethoxysilane
C15H34O3Si
Chemical Formula:

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Section 4. FIRST AID MEASURES
Inhalation: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
Get medical advice/attention if you feel unwell.
Dodecyltrimethoxysilane

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Section 4. FIRST AID MEASURES
Skin contact: Remove/Take off immediately all contaminated clothing. Gently wash with plenty of
soap and water. If skin irritation or rash occurs: Get medical advice/attention.
Eye contact: Rinse cautiously with water for several minutes. Remove contact lenses, if present
and easy to do. Continue rinsing. If eye irritation persists: Get medical
advice/attention.
Ingestion: Get medical advice/attention if you feel unwell. Rinse mouth.
A rescuer should wear personal protective equipment, such as rubber gloves and air-
Protection of first-aiders:
tight goggles.

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Section 5. FIRE-FIGHTING MEASURES
Suitable extinguishing Dry chemical, foam, carbon dioxide.
media:
Unsuitable extinguishing Water (It may scatter and spread fire.)
media:
Specific hazards arising Take care as it may decompose upon combustion or in high temperatures to
from the chemical: generate poisonous fume.
Precautions for firefighters: Fire-extinguishing work is done from the windward and the suitable fire-extinguishing
method according to the surrounding situation is used. Uninvolved persons should
evacuate to a safe place. In case of fire in the surroundings: Remove movable
containers if safe to do so.
Special protective When extinguishing fire, be sure to wear personal protective equipment.
equipment for firefighters:

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Section 6. ACCIDENTAL RELEASE MEASURES
Personal precautions, Use personal protective equipment. Keep people away from and upwind of spill/leak.
protective equipment and Ensure adequate ventilation. Entry to non-involved personnel should be controlled
emergency procedures: around the leakage area by roping off, etc.
Environmental precautions: Prevent product from entering drains.
Methods and materials for Absorb spilled material in a suitable absorbent (e.g. rag, dry sand, earth, saw-dust).
containment and cleaning In case of large amount of spillage, contain a spill by bunding. Adhered or collected
up: material should be promptly disposed of, in accordance with appropriate laws and
regulations.

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Section 7. HANDLING AND STORAGE
Precautions for safe handling
Technical measures: Handling is performed in a well ventilated place. Wear suitable protective equipment.
Prevent generation of vapour or mist. Wash hands and face thoroughly after
handling.
Use a ventilation, local exhaust if vapour or aerosol will be generated.
Advice on safe handling: Avoid contact with skin, eyes and clothing.
Conditions for safe storage, including any
incompatibilities
Storage conditions: Keep container tightly closed. Store in a cool and dark place.
Store under inert gas.
Protect from moisture.
Store away from incompatible materials such as oxidizing agents.
Moisture-sensitive
Packaging material: Comply with laws.

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Section 8. EXPOSURE CONTROLS / PERSONAL PROTECTION
Engineering controls: Install a closed system or local exhaust as possible so that workers should not be
exposed directly. Also install safety shower and eye bath.
Personal protective equipment
Respiratory protection: Vapor respirator. Follow local and national regulations.
Protective gloves.
Hand protection:
Eye protection: Safety glasses. A face-shield, if the situation requires.
Dodecyltrimethoxysilane

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Section 8. EXPOSURE CONTROLS / PERSONAL PROTECTION
Skin and body protection: Protective clothing. Protective boots, if the situation requires.

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Section 9. PHYSICAL AND CHEMICAL PROPERTIES
Physical state (20°C): Liquid
Clear
Form:
Colour: Colorless - Almost colorless
No data available
Odour:
pH: No data available
Melting point/freezing point:-40°C
Boiling point/range: 118°C/0.2kPa
Flash point: 108°C
Flammability or explosive
limits:
Lower: No data available
Upper: No data available
Relative density: 0.90
Solubility(ies):
[Water] No data available
[Other solvents] No data available

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Section 10. STABILITY AND REACTIVITY
Chemical stability: Stable under proper conditions.
Possibility of hazardous No special reactivity has been reported.
reactions:
Incompatible materials: Oxidizing agents
Hazardous decomposition Carbon monoxide, Carbon dioxide, Silicon oxides
products:

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Section 11. TOXICOLOGICAL INFORMATION
Acute Toxicity: No data available
Skin corrosion/irritation: No data available
Serious eye No data available
damage/irritation:
Germ cell mutagenicity: No data available
Carcinogenicity:
No data available
IARC =
NTP = No data available
Reproductive toxicity: No data available

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Section 12. ECOLOGICAL INFORMATION
Ecotoxicity:
Fish: No data available
No data available
Crustacea:
Algae: No data available
Persistence / degradability: No data available
Bioaccumulative No data available
potential(BCF):
Mobility in soil
Log Pow: No data available
Soil adsorption (Koc): No data available
Henry's Law No data available
constant(PaM3/mol):
Dodecyltrimethoxysilane

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Section 13. DISPOSAL CONSIDERATIONS
Recycle to process, if possible. Consult your local regional authorities. You may be able to burn in a chemical
incinerator equipped with an afterburner and scrubber system. Observe all federal, state and local regulations when
disposing of the substance.

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Section 14. TRANSPORT INFORMATION
Hazards Class: Does not correspond to the classification standard of the United Nations
UN-No: Not listed

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Section 15. REGULATORY INFORMATION
Safe management ordinance of dangerous chemical product (State Council announces on January 26, 2002
and revised on February 16,2011): Safe use and production, the storage of a dangerous chemical, transport,
loading and unloading were prescribed.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

制备方法与用途

用途：

• 可用作工程塑料改性
• 建筑物防水防蚀
• 橡胶塑料脱模
• 玻璃防雾等

反应信息

• 作为反应物：
  描述：

  十二烷基三甲氧基硅烷 在 六甲基磷酰三胺 、 sodium tetrahydroborate 、 溴乙烷 、 四正辛基溴化铵 作用下， 以 氘代苯 为溶剂， 反应 24.0h， 以76%的产率得到dodecylsilane
  参考文献：
  名称：

  氢硅烷的合成通过路易斯碱催化还原的烷氧基硅烷的用NaBH 4 †

  摘要：

  通过在六甲基磷酸三酰胺（HMPA）作为路易斯碱催化剂的存在下，用BH 3还原烷氧基硅烷来合成氢硅烷。该反应也可通过使用廉价且易于处理的氢化物源NaBH 4来实现，该氢化物源与EtBr作为牺牲试剂反应，就地形成BH 3。

  DOI：

  10.1039/c9cc01961h
• 作为产物：
  描述：

  十二烷基三氯硅烷 在 水 、 碳酸氢钠 作用下， 以 乙醚 、 正己烷 为溶剂， 反应 121.0h， 生成 十二烷基三甲氧基硅烷
  参考文献：
  名称：

  羟基化合和甲氧基动植物的合成和葡糖胺化

  摘要：

  摘要（RSi（CH 3）2 OH，R m SiY 4− m，R = C 12 H 25，C 18 H 37且Y = OH，OMe，m = 1的类型的长链羟基-甲氧基烷基硅烷的合成，2，3）（5，6，7a-c，8a-c，9a-c，10a-c）和烷基甲硅烷基吡喃葡萄糖苷（13，14，15a-c，16a-c）。羟烷基硅烷（5，6，7a-c，8a-c）是通过用NaHCO 3 -H 2 O在乙醚中水解烷基氯硅烷（1a-c，2a-c，3，4）制备的。烷基氯硅烷1a–c和2a–c与KOMe在正己烷中反应，分别得到甲氧基烷基硅烷9a–c和10a–c。烷基氯硅烷1a-c，2a-c，3和4与2,3,4,6-四-O-乙酰基-α/β-d-吡喃葡萄糖12在CH 2 Cl 2中直接反应，得到烷基甲硅烷基吡喃葡萄糖苷13、14， 15a–c和16a–c。

  DOI：

  10.1016/s0008-6215(99)00173-1

文献信息

• Practical Conversion of Chlorosilanes into Alkoxysilanes without Generating HCl
  作者：Ryutaro Wakabayashi、Yasushi Sugiura、Toshimichi Shibue、Kazuyuki Kuroda

  DOI：10.1002/anie.201104948

  日期：2011.11.4

  Alcohol‐free: A versatile, efficient, and practical synthesis of alkoxysilanes without generation of HCl involves the reaction of chlorosilanes with unsymmetrical ethers in the presence of a Lewis acid (see scheme). The reaction proceeds through selective cleavage of CO bonds and is superior to conventional processes. Industrially feasible reagents are used and only one by‐product results.

  无酒精：在不产生HCl的情况下，通用，高效且实用的烷氧基硅烷合成涉及在路易斯酸存在下，氯硅烷与不对称醚的反应（参见方案）。该反应以C选择性裂解 O键和优于常规方法。使用了工业上可行的试剂，仅产生一种副产物。
• 十二烷基二甲氧基(磷杂环甲氧基)硅烷化合 物的制备方法
  申请人：苏州科技大学

  公开号：CN105254677B

  公开（公告）日：2018-02-02

  本发明涉及一种阻燃剂十二烷基二甲氧基(磷杂环甲氧基)硅烷化合物的制备方法，该化合物的结构如下式所示：制备方法为：用氮气保护下，在带有高效分馏装置的反应器内，控制1‑氧‑1‑甲基‑4‑乙基‑4‑羟甲基‑2，6‑二氧杂‑1‑磷杂环己烷与十二烷基三甲氧基硅烷摩尔比为1∶1‑1∶1.4，加入有机溶剂，升温到90‑140℃，分馏出生成的甲醇，分馏反应6‑11h，直到无甲醇产生，经纯化处理得十二烷基二甲氧基(磷杂环甲氧基)硅烷；本发明产品适合用于聚氯乙烯、聚氨酯、不饱和树脂、环氧树脂、呋喃树脂、聚乙烯醇等材料的阻燃剂，且生产工艺简单，设备投资少，易于实现工业化生产，具有很好的应用及开发前景。
• 十二烷基硅酸三(膦杂环甲基)酯化合物的制 备方法
  申请人：苏州科技大学

  公开号：CN105294763B

  公开（公告）日：2017-12-22

  本发明涉及一种阻燃剂十二烷基硅酸三(膦杂环甲基)酯化合物的制备方法，该化合物的结构如下式所示：制备方法为：用氮气置换掉带有高效分馏装置反应器内的空气，控制十二烷基三甲氧基硅烷与1‑氧‑1‑甲基‑4‑乙基‑4‑羟甲基‑2，6‑二氧杂‑1‑磷杂环己烷摩尔比为1∶3‑1∶3.3，升温到120‑160℃，控制分馏柱顶温度不高于65℃，分馏出生成的甲醇，分馏反应11‑17h，直到分出的甲醇达到理论量，经纯化处理，得十二烷基硅酸三(膦杂环甲基)酯；本发明产品结构性能稳定，分散性好，阻燃效果优良，还有成炭作用，适合用于聚酯PBT、PET、聚氨酯、聚丙烯、聚氯乙烯等材料的阻燃剂；其工艺简单，设备投资少，易于规模化生产，具有很好的应用及开发前景。
• 十二烷基硅酸三(膦杂环甲基)酯化合物及其 制备方法
  申请人：苏州科技大学

  公开号：CN105384776B

  公开（公告）日：2017-09-29

  本发明涉及一种磷硅协同阻燃剂十二烷基硅酸三(膦杂环甲基)酯化合物及其制备方法，该化合物的结构如下式所示：制备方法为：氮气保护下，控制十二烷基三甲氧基硅烷与4‑乙基‑2，6，7‑三氧杂‑1‑磷杂双环[2.2.2]辛烷的摩尔比为1∶3‑1∶3.3，在催化剂作用下，升温到140‑190℃，反应14‑22h，经纯化处理，得产品十二烷基硅酸三(膦杂环甲基)酯。本发明产品阻燃效能高，成炭性好，还有防熔融滴落作用，适合用作聚酯PBT、PET、聚氨酯、尼龙、聚丙烯等材料的阻燃剂；并且生产工艺简单，设备投资少，易于规模化生产。
• Preparation and Properties of Trialkylfluorosilanes¹
  作者：H. HARRY SZMANT、GERALD W. MILLER、J. MAKHLOUF、KURT C. SCHREIBER

  DOI：10.1021/jo01048a063

  日期：1962.1

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