1-Benzyl-4-dimethoxymethyl-3-(toluene-4-sulfonyl)-piperidine-2,6-dione | 640722-78-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 1-Benzyl-4-dimethoxymethyl-3-(toluene-4-sulfonyl)-piperidine-2,6-dione
• 英文别名: 1-Benzyl-4-(dimethoxymethyl)-3-(4-methylphenyl)sulfonylpiperidine-2,6-dione；1-benzyl-4-(dimethoxymethyl)-3-(4-methylphenyl)sulfonylpiperidine-2,6-dione
• CAS: 640722-78-7
• 化学式: C₂₂H₂₅NO₆S
• 分子量: 431.51
• InChiKey: RIEZVRWHXSPRAF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  30
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  98.4
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  1-Benzyl-4-dimethoxymethyl-3-(toluene-4-sulfonyl)-piperidine-2,6-dione 在 lithium aluminium tetrahydride 、 sodium hydride 、 三乙胺 、 sodium iodide 作用下， 以 四氢呋喃 为溶剂， 生成 1-Benzyl-4-dimethoxymethyl-3-(4-methoxy-benzyl)-3-(toluene-4-sulfonyl)-piperidin-2-one
  参考文献：
  名称：

  Synthesis of 3,4-dihydrobenzo[g]isoquinoline-1(2H)-ones and 3,4-dihydroisoquinoline-1(2H)-ones skeleton via intramolecular electrophilic cyclization

  摘要：

  An original alternative approach to isoquinolines based on the installation of a benzene nucleus on a performed heterocyclic ring. Synthesis of 3,4-dihydrobenzo[g]isoquinoline-1(2H)-ones and 3,4-dihydroisoquinoline-1(2H)-ones via intramolecular electrophilic cyclization of 3,4-disubstituted lactams is reported. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2004.09.015
• 作为产物：
  描述：

  4,4-二甲氧基-2-丁烯酸乙酯 、 N-benzyl-2-p-toluenesulfonylacetamide 在 base 作用下， 生成 1-Benzyl-4-dimethoxymethyl-3-(toluene-4-sulfonyl)-piperidine-2,6-dione
  参考文献：
  名称：

  Synthesis of 3,4-dihydrobenzo[g]isoquinoline-1(2H)-ones and 3,4-dihydroisoquinoline-1(2H)-ones skeleton via intramolecular electrophilic cyclization

  摘要：

  An original alternative approach to isoquinolines based on the installation of a benzene nucleus on a performed heterocyclic ring. Synthesis of 3,4-dihydrobenzo[g]isoquinoline-1(2H)-ones and 3,4-dihydroisoquinoline-1(2H)-ones via intramolecular electrophilic cyclization of 3,4-disubstituted lactams is reported. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2004.09.015

文献信息

• Regioselective reduction of N-alkyl-3-sulfonyl glutarimides to δ-lactams. Formal synthesis of (±)-paroxetine and (±)-tacamonine
  作者：Chung-Yi Chen、Bo-Rui Chang、Min-Ruei Tsai、Meng-Yang Chang、Nein-Chen Chang

  DOI：10.1016/j.tet.2003.09.076

  日期：2003.11

  A convenient method for the preparation of 4- or 5-substituted 3-sulfonyl-δ-lactams via regioselective reduction of N-alkyl-3-sulfonyl glutarimides is described. Formal synthesis of (±)-paroxetine and (±)-tacamonine is also reported.

  描述了一种通过区域选择性还原N-烷基-3-磺酰基戊二酰亚胺制备4-或5-取代的3-磺酰基-δ-内酰胺的简便方法。还报道了（±）-帕罗西汀和（±）-塔卡莫宁的形式合成。
• Synthesis of 3,4-dihydrobenzo[g]isoquinoline-1(2H)-ones and 3,4-dihydroisoquinoline-1(2H)-ones skeleton via intramolecular electrophilic cyclization
  作者：Min-Ruei Tsai、Ta-Chao Hung、Bo-Fong Chen、Chih-Ching Cheng、Nein-Chen Chang

  DOI：10.1016/j.tet.2004.09.015

  日期：2004.11

  An original alternative approach to isoquinolines based on the installation of a benzene nucleus on a performed heterocyclic ring. Synthesis of 3,4-dihydrobenzo[g]isoquinoline-1(2H)-ones and 3,4-dihydroisoquinoline-1(2H)-ones via intramolecular electrophilic cyclization of 3,4-disubstituted lactams is reported. (C) 2004 Elsevier Ltd. All rights reserved.