1-benzopyrano[3,2-c]pyridin-10-one | 54629-30-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 1-benzopyrano[3,2-c]pyridin-10-one
• 英文别名: 10H-benzopyrano[3,2-c]pyridin-10-one；chromeno[3,2-c]pyridin-10-one；Chromeno[3,2-c]pyridin-10-on；10H-[1]Benzopyrano[3,2-c]pyridin-10-one；chromeno[3,2-c]pyridin-10-one
• CAS: 54629-30-0
• 化学式: C₁₂H₇NO₂
• 分子量: 197.193
• InChiKey: FQBZYKCEPGMXSU-UHFFFAOYSA-N

物化性质

• 熔点：
  184 °C
• 沸点：
  380.6±11.0 °C(Predicted)
• 密度：
  1.342±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  15
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  39.2
• 氢给体数：
  0
• 氢受体数：
  3

安全信息

• 海关编码：
  2934999090

反应信息

• 作为反应物：
  描述：

  1-benzopyrano[3,2-c]pyridin-10-one 以80%的产率得到
  参考文献：
  名称：

  VILLANI F. J.; MANN T. A.; WEFER E. A.; HANNON J.; LARCA L. L.; LANDON M.+, J. MED. CHEM. , 1975, 18, NO 1, 1-8

  摘要：

  DOI：
• 作为产物：
  描述：

  4-phenoxypyridin-3-amine 在 硫酸 、 水 作用下， 生成 1-benzopyrano[3,2-c]pyridin-10-one
  参考文献：
  名称：

  黄原酮和噻吨酮。第六部分 9-硫杂-3-氮杂蒽酮的制备及性质

  摘要：

  DOI：

  10.1039/jr9550002755

文献信息

• MODULATORS OF GLUCOCORTICOID RECEPTOR, AP-1, AND/OR NF-kB ACTIVITY AND USE THEREOF
  申请人：Weinstein David S.

  公开号：US20090075995A1

  公开（公告）日：2009-03-19

  Novel non-steroidal compounds are provided which are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity, including inflammatory and immune diseases, having the structure of formula (I): an enantiomer, diastereomer, or tautomer thereof, or a prodrug ester thereof, or a pharmaceutically-acceptable salt thereof, in which: Z is heterocyclo or heteroaryl; A is a 5- to 8-membered carbocyclic ring or a 5- to 8-membered heterocyclic ring; B is a cycloalkyl, cycloalkenyl, aryl, heterocyclo, or heteroaryl ring, wherein each ring is fused to the A ring on adjacent atoms and optionally substituted by one to four groups which are the same or different and are independently selected from R 5 , R 6 , R 7 , and R 8 ; J 1 , J 2 , and J 3 are at each occurrence the same or different and are independently -A 1 QA 2 -; Q is a bond, O, S, S(O), or S(O) 2 ; A 1 and A 2 are the same or different and are at each occurrence independently selected from a bond, C 1-3 alkylene, substituted C 1-3 alkylene, C 2-4 alkenylene, and substituted C 2-4 alkenylene, provided that A 1 and A 2 are chosen so that ring A is a 5- to 8-membered carbocyclic or heterocyclic ring; R 1 to R 11 are as defined herein. Also provided are pharmaceutical compositions and methods of treating inflammatory- or immune-associated diseases and obesity and diabetes employing said compounds.

  提供了一系列新颖的非甾体化合物，这些化合物在治疗与糖皮质激素受体、AP-1和/或NF-κB活性调节相关的疾病中很有用，包括炎性和免疫疾病，具有以下结构式（I）： 其对应的光学异构体、对映异构体或互变异构体，或其前药酯，或其药用可接受盐，其中： Z是杂环或杂芳基； A是一个5至8成员的碳环或一个5至8成员的杂环； B是一个环烷基、环烯基、芳基、杂环或杂芳基环，其中每个环都与A环上的相邻原子融合，并且可以选择性地被一个到四个独立选自R5、R6、R7和R8的相同或不同的组取代； J1、J2和J3每次出现时相同或不同，独立地选自-A1QA2-；Q是键、O、S、S(O)或S(O)2；A1和A2相同或不同，每次出现时独立地选自键、C1-3烷基、取代的C1-3烷基、C2-4烯基和取代的C2-4烯基，前提是A1和A2的选择使得环A是一个5至8成员的碳环或杂环； R1至R11如本文所述定义。 还提供了使用这些化合物的药物组合物和治疗炎性疾病、免疫相关疾病、肥胖和糖尿病的方法。
• Intramolecular Anionic Friedel-Crafts Equivalents. A General Regiospecific Route to Substituted and Naturally Occurring Xanthen-9-ones
  作者：O. Familoni、Ileana Ionica、Justin Bower、Victor Snieckus

  DOI：10.1055/s-1997-1533

  日期：1997.9

  An LDA-induced regiospecific and general conversion of diaryl ether 2-carboxamides 4 into substituted xanthones 5, including natural products, 2-hydroxy-1-methoxyxanthone (8) and 6-deoxy-jacareubin (14), is described.

  报道了一种由线性判别分析诱导的、对二芳基醚2-羧酰胺4的区域特异性及普遍性转化，生成取代咕吨酮5，包括天然产物2-羟基-1-甲氧基咕吨酮(8)和6-脱氧雅卡尔宾(14)。
• [EN] LUMINESCENT LANTHANIDE COMPLEXES<br/>[FR] COMPLEXES LUMINESCENTS DE LANTHANIDES
  申请人：UNIV DURHAM

  公开号：WO2010086615A1

  公开（公告）日：2010-08-05

  The invention provides a compound of formula (I): wherein: R1 is an optionally substituted 2-(1-azathiaxanthone); each -R2 is independently of the formula -CH2-C(=O)-R4, wherein R4 is an amino acid or a salt thereof, attached to the remainder of R2 through the nitrogen atom of the amino group; and R3 is hydrogen or a C1-6 alkyl group); or (wherein: R1 is an optionally substituted 2-(1-azaxanthone); each R2 is independently an optionally substituted glutaric or succinic acid, or a salt or ester thereof; and R3 is hydrogen or a C1-6 alkyl group).

  本发明提供了一个化合物，其化学式为（I）：其中：R1是可选取代的2-（1-氮杂黄酮）;每个-R2独立地是公式-CH2-C（=O）-R4，其中R4是氨基酸或其盐，通过氨基团的氮原子连接到R2的其余部分;而R3是氢或C1-6烷基）;或（其中：R1是可选取代的2-（1-氮杂黄色素）;每个R2独立地是可选取代的戊二酸或琥珀酸，或其盐或酯;而R3是氢或C1-6烷基）。
• ORGANIC ELECTROLUMINESCENCE DEVICE AND POLYCYCLIC COMPOUND FOR ORGANIC ELECTROLUMINESCENCE DEVICE
  申请人：Samsung Display Co., Ltd.

  公开号：US20190312210A1

  公开（公告）日：2019-10-10

  An organic electroluminescence device includes a first electrode, a hole transport region on the first electrode, an emission layer on the hole transport region, an electron transport region on the emission layer, and a second electrode on the electron transport region, wherein the emission layer includes a polycyclic compound represented by Formula 1. In Formula 1, X 1 may be C, Si or Ge; and AC may be an electron acceptor.

  一种有机电致发光器件包括第一电极、位于第一电极上的空穴传输区域、位于空穴传输区域上的发射层、位于发射层上的电子传输区域和位于电子传输区域上的第二电极，其中发射层包括由式1表示的多环化合物。在式1中，X1 可以是C、Si或Ge; AC 可以是电子受体。
• Synthesis of azafluorenones and related compounds using deprotocupration–aroylation followed by intramolecular direct arylation
  作者：Nada Marquise、Philip J. Harford、Floris Chevallier、Thierry Roisnel、Vincent Dorcet、Anne-Laure Gagez、Sophie Sablé、Laurent Picot、Valérie Thiéry、Andrew E.H. Wheatley、Philippe C. Gros、Florence Mongin

  DOI：10.1016/j.tet.2013.09.030

  日期：2013.11

  The efficiency of the deprotocupration-aroylation of 2-chloropyridine using lithiocuprates prepared from CuX (X=Cl, Br) and LiTMP (TMP=2,2,6,6-tetramethylpiperidido, 2 equiv) was investigated. CuCl was identified as a more suitable copper source than CuBr for this purpose. Different diaryl ketones bearing a halogen at the 2 position of one of the aryl groups were synthesized in this way from azines and thiophenes. These were then involved in palladium-catalyzed ring closure: substrates underwent expected CH-activation-type arylation to afford fluorenone-type compounds, and were also subjected to cyclization reactions leading to xanthones, notably in the presence of oxygen-containing substituents or reagents. (C) 2013 The Authors. Published by Elsevier Ltd. All rights reserved.

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