oxalic acid (4,5-dimethoxy-2-nitrobenzyl) ester (3',5'-dimethoxybenzoin) ester | 457612-09-8

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: oxalic acid (4,5-dimethoxy-2-nitrobenzyl) ester (3',5'-dimethoxybenzoin) ester
• 英文别名: 1-O-[(4,5-dimethoxy-2-nitrophenyl)methyl] 2-O-[1-(3,5-dimethoxyphenyl)-2-oxo-2-phenylethyl] oxalate
• CAS: 457612-09-8
• 化学式: C₂₇H₂₅NO₁₁
• 分子量: 539.496
• InChiKey: VJTMSILLIUNEQG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  39
• 可旋转键数：
  13
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  152
• 氢给体数：
  0
• 氢受体数：
  11

反应信息

• 作为反应物：
  描述：

  oxalic acid (4,5-dimethoxy-2-nitrobenzyl) ester (3',5'-dimethoxybenzoin) ester 以 乙腈 为溶剂， 反应 24.0h， 以67%的产率得到Oxalic acid mono-[1-(3,5-dimethoxy-phenyl)-2-oxo-2-phenyl-ethyl] ester
  参考文献：
  名称：

  Wavelength-Controlled Orthogonal Photolysis of Protecting Groups

  摘要：

  The selective control of a chemical process by the use of an electromagnetic wave has been a challenging goal for several decades. In this article, we describe for the first time the use of a monochromatic light beam to differentiate two different reactive centers. A direct application of this concept is found in the chemistry of protecting groups. Two different photolabile protecting groups were tuned to be responsive to a specific wavelength (e.g., 254 or 420 nm). Using derivatives of the 2-nitroveratryl fragment (such as 10, sensitive at 420 nm) and 3',5'-dimethoxybenzoin fragment (such as 4, sensitive at 254 nm), it was shown that energy transfer phenomena did not erode the selectivity. Both the inter- and the intramolecular cases were studied and showed selectivities within the synthetically useful range. Hence, we could replace the traditional chemical orthogonality by a chromatic orthogonality.

  DOI：

  10.1021/jo025837m
• 作为产物：
  描述：

  6-硝基藜芦醛 在 4-二甲氨基吡啶 、 sodium tetrahydroborate 、 N,N'-二环己基碳二亚胺 作用下， 以 甲醇 、 二氯甲烷 、 氯仿 为溶剂， 反应 25.0h， 生成 oxalic acid (4,5-dimethoxy-2-nitrobenzyl) ester (3',5'-dimethoxybenzoin) ester
  参考文献：
  名称：

  Wavelength-Controlled Orthogonal Photolysis of Protecting Groups

  摘要：

  The selective control of a chemical process by the use of an electromagnetic wave has been a challenging goal for several decades. In this article, we describe for the first time the use of a monochromatic light beam to differentiate two different reactive centers. A direct application of this concept is found in the chemistry of protecting groups. Two different photolabile protecting groups were tuned to be responsive to a specific wavelength (e.g., 254 or 420 nm). Using derivatives of the 2-nitroveratryl fragment (such as 10, sensitive at 420 nm) and 3',5'-dimethoxybenzoin fragment (such as 4, sensitive at 254 nm), it was shown that energy transfer phenomena did not erode the selectivity. Both the inter- and the intramolecular cases were studied and showed selectivities within the synthetically useful range. Hence, we could replace the traditional chemical orthogonality by a chromatic orthogonality.

  DOI：

  10.1021/jo025837m