8-{[(R)-2,8-diazabicyclo[4.3.0]non-5-en]-8-yl}-1-cyclopropyl-7-fluoro-9-methyl-4-oxo-4H-quinolizine-3-carboxylic acid | 220593-55-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹嗪类
• 英文名称: 8-{[(R)-2,8-diazabicyclo[4.3.0]non-5-en]-8-yl}-1-cyclopropyl-7-fluoro-9-methyl-4-oxo-4H-quinolizine-3-carboxylic acid
• 英文别名: 8-[(7aR)-1,2,3,5,7,7a-hexahydropyrrolo[3,4-b]pyridin-6-yl]-1-cyclopropyl-7-fluoro-9-methyl-4-oxo-quinolizine-3-carboxylic acid；8-[(7aR)-1,2,3,5,7,7a-hexahydropyrrolo[3,4-b]pyridin-6-yl]-1-cyclopropyl-7-fluoro-9-methyl-4-oxoquinolizine-3-carboxylic acid
• CAS: 220593-55-5
• 化学式: C₂₁H₂₂FN₃O₃
• 分子量: 383.422
• InChiKey: ATTWAJLIMNVEMY-KRWDZBQOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.2
• 重原子数：
  28
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  72.9
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  8-chloro-1-cyclopropyl-7-fluoro-9-methyl-4-oxo-4H-quinolizine-3-carboxylic acid 、 1,2-diazabicyclo[5.4.0]undec-7-ene 、 (R)-2,8-diazabicyclo[4.3.0]non-5-ene.2HCl 、 甲烷 以 甲醇 、 二氯甲烷 、 乙腈 为溶剂， 生成 8-{[(R)-2,8-diazabicyclo[4.3.0]non-5-en]-8-yl}-1-cyclopropyl-7-fluoro-9-methyl-4-oxo-4H-quinolizine-3-carboxylic acid
  参考文献：
  名称：

  Quinolizine carboxylic acid derivatives

  摘要：

  一种喹啉酸衍生物（I）或其药学上可接受的盐：其中R1和R2的含义与规范中定义的相同。

  公开号：

  US06235751B1

文献信息

• PHARMACEUTICAL COMPOSITION
  申请人：NAKAGAMI Hiroaki

  公开号：US20070148235A1

  公开（公告）日：2007-06-28

  The present invention relates to a granular pharmaceutical composition comprising a drug having a disagreeable taste, a wax and a sugar alcohol; a method for preparing the same; and a pharmaceutical product for oral administration, comprising the granular composition. The product excellently masks a disagreeable taste possessed by a drug and provides good sensation upon oral administration, and therefore is easily ingested by even the elderly, children, and patients suffering dysphagia. Moreover, the product is suitable for administration using tube.
• US6235751B1
  申请人：——

  公开号：US6235751B1

  公开（公告）日：2001-05-22
• Quinolizine carboxylic acid derivatives
  申请人：Korean Research Institute of Chemical Technology

  公开号：US06235751B1

  公开（公告）日：2001-05-22

  A quinolizine carboxylic acid derivative of formula (I) or a pharmaceutically acceptable salt thereof: wherein R1 and R2 have the same meanings the as defined in the specification.

  一种喹啉酸衍生物（I）或其药学上可接受的盐：其中R1和R2的含义与规范中定义的相同。