N-(2-naphtylmethyl)(3-phenylpropyl)amine | 1040052-69-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: N-(2-naphtylmethyl)(3-phenylpropyl)amine
• 英文别名: N-(naphthalen-2-ylmethyl)-3-phenylpropan-1-amine
• CAS: 1040052-69-4
• 化学式: C₂₀H₂₁N
• 分子量: 275.393
• InChiKey: XMXVTATYLPRZIO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  21
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  3-苯基-1-丙胺 、 2-萘甲醛 在 sodium cyanoborohydride 作用下， 以 甲醇 、 乙醇 为溶剂， 反应 8.0h， 以100%的产率得到N-(2-naphtylmethyl)(3-phenylpropyl)amine
  参考文献：
  名称：

  Structure–activity relationships of small molecule inhibitors of RAGE-Aβ binding

  摘要：

  The Receptor for Advanced Glycation Endproducts ('RAGE') mediates transport of amyloid-beta peptide (A beta) into the brain, and is therefore an important target for the development of therapeutic agents for Alzheimer's disease. We describe structure activity relationships for inhibition of RAGE-A beta binding, derived from the analysis of a library of tertiary amides. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2013.05.079

文献信息

• A Biomimetic Electrocatalytic System for the Atom-Economical Chemoselective Synthesis of Secondary Amines
  作者：Martine Largeron、Maurice-Bernard Fleury

  DOI：10.1021/ol802885b

  日期：2009.2.19

  A facile one-pot oxidation-imine formation-reduction route to secondary amines can be achieved electrolytically from primary amines. This atom-economical 1(ox)-mediated sequence, leaving ammonia as the sole byproduct, allows the rapid chemoselective synthesis of secondary amines, at both ambient temperature and pressure.
• Structure–activity relationships of small molecule inhibitors of RAGE-Aβ binding
  作者：Nathan T. Ross、Rashid Deane、Sheldon Perry、Benjamin L. Miller

  DOI：10.1016/j.tet.2013.05.079

  日期：2013.9

  The Receptor for Advanced Glycation Endproducts ('RAGE') mediates transport of amyloid-beta peptide (A beta) into the brain, and is therefore an important target for the development of therapeutic agents for Alzheimer's disease. We describe structure activity relationships for inhibition of RAGE-A beta binding, derived from the analysis of a library of tertiary amides. (C) 2013 Elsevier Ltd. All rights reserved.