8-methoxy-chromeno[2,3-b]pyridin-5-one | 52206-37-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 8-methoxy-chromeno[2,3-b]pyridin-5-one
• 英文别名: 7-Methoxy-1-aza-xanthone；8-Methoxy-1-azaxanthon；8-Methoxychromeno[2,3-b]pyridin-5-one
• CAS: 52206-37-8
• 化学式: C₁₃H₉NO₃
• 分子量: 227.219
• InChiKey: QWURLELNXOTXSV-UHFFFAOYSA-N

物化性质

• 熔点：
  179-180 °C(Solv: ethyl acetate (141-78-6))
• 沸点：
  416.4±45.0 °C(Predicted)
• 密度：
  1.330±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  48.4
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  8-methoxy-chromeno[2,3-b]pyridin-5-one 以53%的产率得到
  参考文献：
  名称：

  VILLANI F. J.; MANN T. A.; WEFER E. A.; HANNON J.; LARCA L. L.; LANDON M.+, J. MED. CHEM. , 1975, 18, NO 1, 1-8

  摘要：

  DOI：
• 作为产物：
  描述：

  Li-10 生成 8-methoxy-chromeno[2,3-b]pyridin-5-one
  参考文献：
  名称：

  Benzopyranopyridine derivatives. 1. Aminoalkyl derivatives of the azaxanthenes as bronchodilating agents

  摘要：

  The preparation of the four isomeric azaxanthones 3 and a number of their aromatic ring substituted derivatives is described. These ketones were converted into the title compounds which were examined for their biological properties. The most interesting compound in this series, the 1-methyl-4-piperidylidene derivative of 1-azaxanthene, shows the profile of an orally effective potent bronchodilating agent as well as a moderate antihistamine. Biological properties of this compound were compared to a number of antihistamines as well as known bronchodilating agents. Structure-activity relationships are also discussed.

  DOI：

  10.1021/jm00235a001

文献信息

• Gastric antisecretory agents. 2. Antisecretory activity of 9-[(aminoalkyl)thio]-9H-xanthenes and 5-[(aminoalkyl)thio]-5H-[1]benzopyrano[2,3-b]pyridines
  作者：James A. Bristol、Elijah H. Gold、Irwin Gross、Raymond G. Lovey、James F. Long

  DOI：10.1021/jm00140a020

  日期：1981.8

  A series of 9-[(aminoalkyl)thio]-9H-xanthenes (3-6) and 5-[(aminoalkyl)thio]-5H-[1]benzopyrano[2,3-b]pyridines (7-10) possessing gastric antisecretory activity in the rat and dog is described Many of the compounds possessed good activity in the pylorus-ligated rat and several inhibited histamine-stimulated gastric acid secretion in the dog. The mechanism of acid secretion inhibition is not related

  一系列9-[（（氨基烷基）硫基] -9H-黄嘌呤（3-6）和5-[（（氨基烷基）硫基] -5H- [1]苯并吡喃并[2,3-b]吡啶（7-10）具有描述了在大鼠和狗中的胃抗分泌活性许多化合物在幽门结扎的大鼠中具有良好的活性，并且在狗中抑制了组胺刺激的胃酸分泌。抑制酸分泌的机制与抗胆碱能或组胺（H2）受体拮抗作用无关。
• Valenti; Borraccini; Primofiore, Chimica therapeutica, 1973, vol. 8, # 6, p. 652 - 654
  作者：Valenti、Borraccini、Primofiore、Da Re

  DOI：——

  日期：——