4-[3-[4-(2-Methoxyphenyl)piperazin-1-yl]propoxy]benzene-1,2-diamine | 958264-67-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 4-[3-[4-(2-Methoxyphenyl)piperazin-1-yl]propoxy]benzene-1,2-diamine
• CAS: 958264-67-0
• 化学式: C₂₀H₂₈N₄O₂
• 分子量: 356.468
• InChiKey: RUHWBTQFJMQKES-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  26
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  77
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  甲酸 、 4-[3-[4-(2-Methoxyphenyl)piperazin-1-yl]propoxy]benzene-1,2-diamine 在 盐酸 作用下， 以90%的产率得到6-[3-[4-(2-methoxyphenyl)piperazin-1-yl]propoxy]-1H-benzimidazole
  参考文献：
  名称：

  Two new phenylpiperazines with atypical antipsychotic potential

  摘要：

  Two new series of substituted arylpiperazines with heterocyclic 3-propoxy-benzimidazole or 3-propoxy-benzimidazole-2-thione groups were synthesized and their in vitro binding affinities for the D,, 5-HT1A, 5-HT2A, and alpha-adrenergic receptors determined. Among them, only two compounds with phenyl aryl-constituent (8a and 9a) showed 5-HT2A/D-2 pK(i) binding ratios proposed for atypical neuroleptics. As to their behavioral screening on rodents, both compounds exhibited a non-cataleptic action in rats and antagonized D-amphetamine-induced hyperlocomotion in mice, suggesting their possible atypical antipsychotic potency. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.08.066
• 作为产物：
  描述：

  4-(3-(4-(2-methoxyphenyl)piperazin-1-yl)propoxy)-2-nitroaniline 在 RaNi 肼 作用下， 生成 4-[3-[4-(2-Methoxyphenyl)piperazin-1-yl]propoxy]benzene-1,2-diamine
  参考文献：
  名称：

  Two new phenylpiperazines with atypical antipsychotic potential

  摘要：

  Two new series of substituted arylpiperazines with heterocyclic 3-propoxy-benzimidazole or 3-propoxy-benzimidazole-2-thione groups were synthesized and their in vitro binding affinities for the D,, 5-HT1A, 5-HT2A, and alpha-adrenergic receptors determined. Among them, only two compounds with phenyl aryl-constituent (8a and 9a) showed 5-HT2A/D-2 pK(i) binding ratios proposed for atypical neuroleptics. As to their behavioral screening on rodents, both compounds exhibited a non-cataleptic action in rats and antagonized D-amphetamine-induced hyperlocomotion in mice, suggesting their possible atypical antipsychotic potency. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.08.066

文献信息

• [EN] FUNCTIONALLY SELECTIVE LIGANDS OF DOPAMINE D2 RECEPTORS<br/>[FR] LIGANDS FONCTIONNELLEMENT SÉLECTIFS DES RÉCEPTEURS D2 DE DOPAMINE
  申请人：UNIV NORTH CAROLINA

  公开号：WO2012003418A2

  公开（公告）日：2012-01-05

  The present invention relates to novel functionally selective ligands of dopamine D2 receptors, including agonists, antagonists, and inverse agonists. The invention further relates to the use of these compounds for treating central nervous system disorders related to D2 receptors.