2,2,8,8-tetramethyl-2,3,7,8-tetrahydro-4H,6H-benzo<1,2-b: 5,4-b'>dipyrane-4,6-dione | 119840-32-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 2,2,8,8-tetramethyl-2,3,7,8-tetrahydro-4H,6H-benzo<1,2-b: 5,4-b'>dipyrane-4,6-dione
• 英文别名: 2,2,8,8-tetramethyl-2,3,7,8-tetrahydro-4H,6H-benzo-<1,2-b:5,4-b'>dipyran-4,6-dione；2,2,8,8-tetramethyl-2,3,7,8-tetrahydropyrano[3,2-g]chromene-4,6-dione；2,2,8,8-Tetramethyl-2,3,7,8-tetrahydropyrano-[3,2-g]chromene-4,6-dione；2,2,8,8-tetramethyl-3,7-dihydropyrano[3,2-g]chromene-4,6-dione
• CAS: 119840-32-3
• 化学式: C₁₆H₁₈O₄
• 分子量: 274.317
• InChiKey: VSIQWQDWBFTRTC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  20
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2,2,8,8-tetramethyl-2,3,7,8-tetrahydro-4H,6H-benzo<1,2-b: 5,4-b'>dipyrane-4,6-dione 在 lithium aluminium tetrahydride 、 4-甲基苯磺酸吡啶 作用下， 生成 2,2,8,8-tetramethyl-2H,8H-benzo<1,2-b: 5,4-b'>dipyran
  参考文献：
  名称：

  Heterocycles from Diacetyl Phenols: Synthesis of Benzodioyrans, Acetylchromenes and Pyrano[1,2]benzisoxazoles

  摘要：

  DOI：

  10.3987/com-88-s135
• 作为产物：
  描述：

  resorcine-di(3-methyl)-2-butenoate 在 sodium hydroxide 、 potassium carbonate 作用下， 以 正己烷 为溶剂， 反应 48.0h， 生成 2,2,8,8-tetramethyl-2,3,7,8-tetrahydro-4H,6H-benzo<1,2-b: 5,4-b'>dipyrane-4,6-dione
  参考文献：
  名称：

  Miranda, Miguel A.; Primo, Jaime; Tormos, Rosa, Heterocycles, 1988, vol. 27, # 3, p. 673 - 682

  摘要：

  DOI：

文献信息

• Solvent-free microwave-assisted synthesis and biological evaluation of aurones and flavanones based on 2,2-dimethylchroman-4-one
  作者：Dongamanti Ashok、Rayagiri Suneel Kumar、Devulapally Mohan Gandhi、Anireddy Jayashree

  DOI：10.1007/s10593-016-1917-4

  日期：2016.7

  A series of novel 8-aryl-2,2-dimethyl-2,3,7,8-tetrahydropyrano[3,2-g]chromene-4,6-dione and 2-arylidene-7,7-dimethyl-6,7-dihydro-2H-furo[3,2-g]chromene-3,5-dione derivatives have been synthesized by oxidation of the corresponding chalcones under microwave irradiation. All newly synthesized compounds were characterized by IR, 1H, 13C NMR, and mass spectra and valuated for their in vitro antibacterial

  一系列新颖的8-芳基-2,2-二甲基-2,3,7,8-四氢吡喃[3,2 - g ]色烯-4,6-二酮和2-亚芳基-7,7-二甲基-6，通过在微波辐射下氧化相应的查耳酮，已经合成了7-二氢-2 H-呋喃[3,2-g]亚甲基-3,5-二酮衍生物。所有新合成的化合物均通过IR，1 H，13 C NMR和质谱进行表征，并对其体外抗菌和抗真菌活性进行了评估。
• Solvent-free microwave-assisted synthesis and biological evaluation of 2,2-dimethylchroman-4-one based benzofurans
  作者：Dongamanti Ashok、Rayagiri Suneel Kumar、Devulapally Mohan Gandhi、Madderla Sarasija、Anireddy Jayashree、Shaik Adam

  DOI：10.1515/hc-2016-0147

  日期：2016.12.1

  A series of novel chroman-4-one fused benzofurans were synthesized by cyclization of the corresponding chalcones under microwave irradiation. All new compounds were characterized by IR, ¹H NMR, ¹³C NMR and mass spectral data and were evaluated for their in vitro antimicrobial and antioxidant activities.

  摘要 通过在微波辐射下合成相应的查尔酮，合成了一系列新颖的嵌合苯并呋喃类色素-4-酮。所有新化合物均通过红外光谱、1H核磁共振、13C核磁共振和质谱数据进行表征，并评估其体外抗微生物和抗氧化活性。
• The first ionic liquid-promoted Kabbe condensation reaction for an expeditious synthesis of privileged bis-spirochromanone scaffolds
  作者：M. Muthukrishnan、U.M.V. Basavanag、Vedavati G. Puranik

  DOI：10.1016/j.tetlet.2009.03.104

  日期：2009.6

  A variety of privileged bis-spirochromanones were synthesized for the first time from 4,6-diacetyl resorcinol in one-pot by carrying out the Kabbe condensation in room temperature ionic liquid [bbim]Br.

  通过在室温离子液体[bbim] Br中进行Kabbe缩合反应，由一锅中的4,6-二乙酰基间苯二酚首次合成了多种特有的双-螺并铬烷酮。
• Banerji, A.; Goomer, N. C.; Kalena, G. P., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1988, vol. 27, # 1-12, p. 981 - 984
  作者：Banerji, A.、Goomer, N. C.、Kalena, G. P.

  DOI：——

  日期：——
• Banerji, A.; Kalena, G.P., Synthetic Communications, 1989, vol. 19, # 1, 2, p. 159 - 166
  作者：Banerji, A.、Kalena, G.P.

  DOI：——

  日期：——